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README.md | 3 years ago |
Z-scored firing rate of L5 pyramidal neurons in expert and naive rats during the microstimulation task. Normalized by responses during pre-stimulus period [-1 0] s.
Condition | Description |
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Expert | Animals after >3 days of training. |
Naive | Animals without pairing sessions. |
Entry | Description |
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<cond>_PSTHz |
Z-scores of firing rate responses. |
<cond>_sorted |
Index for sorting cells as in figures. Sorted by mean z-score of [0.2 0.5] s bins. |
binsize |
Binsize for z-scored PSTHs. 50 ms. |
preStim |
Pre-stimulus window. 1 s. |
postStim |
Post-stimulus window. 3 s. |
PSTHs of three distinctive subpopulations of L5 pyramidal neurons in expert rats. [cellNum x binNum] binsize: 100 ms pre-stimulus window: [-2 0] s post-stimulus window: [0 2] s
Condition | Description |
---|---|
ON | Cells with post-stimulus firing rate in [0.3 0.4] s period above mean + 3 x standard deviation (SD). |
OFF | Cells with post-stimulus firing rate in [0.3 0.4] s period below mean - 3 x standard deviation (SD). |
NR | Rest of the cells. |
Entry | Description |
---|---|
<cond>_PSTH |
PSTHs of firing rate responses. |
<cond>_bPSTH |
PSTHs of burst rate responses. |
Motion-corrected peri-stimulus calcium transients (ΔF/F0) of three distinctive subpopulations of L5 apical dendrites in expert mice. Frame rate at 58.62 Hz. Pre-stimulus 1 s and post-stimulus 3.1 s window.
Condition | Description |
---|---|
ON | Dendrites with post-stimulus calcium transients above mean + 3 x standard deviation (SD). |
OFF | Dendrites with post-stimulus calcium transients below mean - 3 x standard deviation (SD). |
NR | Rest of the dendrites. |
Field | Description |
---|---|
avgTrace |
Average peri-stimulus calcium traces (ΔF/F0) for each dendrite. |
Effects of optogenetic and pharmacological manipulations of dendritic activity on learning of the microstimulation detection task.
Condition | Description |
---|---|
Ctrl | Animals after pairing sessions. No virus expression, but CNO was injected into L1 of S1. |
BacL1 | Animals after pairing sessions. GABAb receptor agonist baclofen was applied to L1 of S1. |
SST | SST-cre x ChR2 mice after pairing sessions. Somatostatin-positive interneurons were optogenetically activated by LED illumination on the surface of S1. |
Entry | Description |
---|---|
<cond>_cumvals |
The cumulative learning curve statistics for the condition. Values on row N (N=1, ... 100) represents the cumulative learning score of each animal after N trials. |
<cond> |
The normalized learning scores for each animal belonging to the condition. |
datacite.yml | |
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Title | Perirhinal input to neocortical layer 1 controls learning |
Authors |
Doron,Guy;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-1252-5747
Shin,Jiyun N.;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-0534-6938 Takahashi,Naoya;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany. Present address: University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, 33000 Bordeaux,France.;ORCID: 0000-0002-6008-4627 Drüke,Moritz;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-6787-9377 Bocklisch,Christina;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: Skenderi,Salina;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-4779-4541 de Mont,Lisa;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-3829-0712 Toumazou,Maria;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: Ledderose,Julia;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0001-5458-6287 Colomb,Julien;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-3127-5520 Sehara,Keisuke;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-4368-8143 Brecht,Michael;Bernstein Center for Computational Neuroscience, House 6, Philippstr. 13, Humboldt Universität, Berlin, 10115 Germany. NeuroCure Cluster, Charité - Universitätsmedizin Berlin, D-10117 Berlin, Germany.;ORCID: 0000-0002-5387-0953 Naud,Richard;University of Ottawa Brain and Mind Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada. Department of Physics, University of Ottawa, Ottawa, ON K1N 6N5, Canada;ORCID: 0000-0001-7383-3095 Larkum,Matthew E.;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0001-9799-2656 |
Description | This repository contains behavioral, electrophysiological, functional imaging (two-photon imaging) and anatomical data that support our findings on the functional role of perirhinal input to neocortical layer 1 on learning. |
License | Creative Commons Attribution 4.0 International Public License (https://creativecommons.org/licenses/by/4.0/) |
References |
Perirhinal input to neocortical layer 1 controls learning [doi:10.1126/science.aaz3136] (IsSupplementTo)
|
Funding |
DFG, LA 3442/2-1
DFG, EXC 257 NeuroCure DFG, DFG.327654276 (SFB 1315) EU, EU, EU.720270 (HBP SGA1) EU, EU.785907 (HBP SGA2) EU, EU.945539 (HBP SGA3) EU, EU.670118 (Active Cortex) Einstein Stiftung, EVF-2017-363 EMBO, ALTF 75-2014 NSERC, RGPIN-2017-06872 CIHR, RN383647–418955 |
Keywords |
Systems Neuroscience
Electrophysiology Behavior Learning and memory Neocortex Primary somatosensory cortex (S1) Dendrites L5 pyramidal neuron Perirhinal cortex Layer 1 |
Resource Type |
Dataset |