Data for Doron, Shin, et al., "Perirhinal input to neocortical layer 1 controls learning".

Jiyun Shin b35bc00b2a Update 'datacite.yml' 1 year ago
Figure 1 3b1664652a Update 'Figure 1/README.md' 1 year ago
Figure 2 5cf7fad4b3 Add 'Figure 2/README.md' 1 year ago
Figure 3 1924576541 Update 'Figure 3/README.md' 1 year ago
Figure 4 71dfea901d Update 'Figure 4/README.md' 1 year ago
Figure S1 d2d6b9eb63 Update 'Figure S1/README.md' 1 year ago
Figure S2 26139554eb Update 'Figure S2/README.md' 1 year ago
Figure S3 4fb16a7bef Add 'Figure S3/README.md' 1 year ago
Figure S4 3fe73aff32 Update 'Figure S4/README.md' 1 year ago
Figure S5 08169398e0 Update 'Figure S5/README.md' 1 year ago
Figure S6 90a4bf4895 Add 'Figure S6/README.md' 1 year ago
Figure S7 019e0cb509 gin commit from DESKTOP-593CF0Q 1 year ago
Figure S9 9216ad9d31 Add 'Figure S9/README.md' 1 year ago
Text_exports 4f0bc20f76 gin commit from MacBook-Pro-4 1 year ago
codes d63557a47b add license for code 1 year ago
.gitignore 1008b33c31 Initial commit 1 year ago
GIN_sync_UNIX bea04c20d6 gin commit from Amo.local 1 year ago
GIN_sync_windows.bat bea04c20d6 gin commit from Amo.local 1 year ago
LICENSE 1008b33c31 Initial commit 1 year ago
README.md 7336ccb27f Update 'README.md' 1 year ago
datacite.yml b35bc00b2a Update 'datacite.yml' 1 year ago

README.md

Data for: "Perirhinal input to neocortical layer I controls learning"

Guy Doron, Jiyun N. Shin, Naoya Takahashi, Moritz Drüke, Christina Bocklisch, Salina Skenderi, Lisa de Mont, Maria Toumazou, Julia Ledderose, Michael Brecht, Richard Naud, and Matthew E. Larkum

If you are using this dataset, please cite the dataset and the paper (use the doi provided to obtain correct citation in your reference manager). If you are using the code, please cite the science paper.

Data is distributed under a CC-BY 4.0 license, code is distributed under a MIT license.

This repository contains behavioral, electrophysiological, functional imaging (two-photon imaging) and anatomical data that were used to generate figures in our paper "Perirhinal input to neocortical layer I controls learning" by Doron, Shin et al., 2020 (doi: 10.1126/science.aaz3136).

Abstract

Hippocampal output influences memory formation in the neocortex but this process is poorly understood because the precise anatomical location and the underlying cellular mechanisms remain elusive. Here, we show that perirhinal input, predominantly to sensory cortical layer 1 (L1), controls hippocampal-dependent associative learning. This process was marked by the emergence of distinct firing responses in defined subpopulations of L5 pyramidal neurons whose tuft dendrites receive perirhinal inputs in L1. Learning correlated with burst firing and enhancement of dendritic excitability and was suppressed by disruption of dendritic activity. Furthermore, bursts, but not regular spike trains, were sufficient to retrieve learned behavior. We conclude that hippocampal information arriving at L5 tuft dendrites in neocortical L1 mediates memory formation in the neocortex.

Contents

  • Each figure folder contains pre-processed data (.mat or .xlsx files) to reproduce corresponding figures.
  • The details of the data are documented in README.md inside the folders.
  • Codes folder contains relevant codes used in this study.
  • In the Text_export folder, you will find spreadsheet that were created by exporting the .mat files into .tsv files, each file got described shortly in the 001_file_index.tsv file. It was mostly done automatically via a R script availabe in the codes folder
datacite.yml
Title Perirhinal input to neocortical layer 1 controls learning
Authors Doron,Guy;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-1252-5747
Shin,Jiyun N.;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-0534-6938
Takahashi,Naoya;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany. Present address: University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, 33000 Bordeaux,France.;ORCID: 0000-0002-6008-4627
Drüke,Moritz;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-6787-9377
Bocklisch,Christina;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID:
Skenderi,Salina;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-4779-4541
de Mont,Lisa;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-3829-0712
Toumazou,Maria;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID:
Ledderose,Julia;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0001-5458-6287
Colomb,Julien;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-3127-5520
Sehara,Keisuke;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-4368-8143
Brecht,Michael;Bernstein Center for Computational Neuroscience, House 6, Philippstr. 13, Humboldt Universität, Berlin, 10115 Germany. NeuroCure Cluster, Charité - Universitätsmedizin Berlin, D-10117 Berlin, Germany.;ORCID: 0000-0002-5387-0953
Naud,Richard;University of Ottawa Brain and Mind Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada. Department of Physics, University of Ottawa, Ottawa, ON K1N 6N5, Canada;ORCID: 0000-0001-7383-3095
Larkum,Matthew E.;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0001-9799-2656
Description This repository contains behavioral, electrophysiological, functional imaging (two-photon imaging) and anatomical data that support our findings on the functional role of perirhinal input to neocortical layer 1 on learning.
License Creative Commons Attribution 4.0 International Public License (https://creativecommons.org/licenses/by/4.0/)
References Perirhinal input to neocortical layer 1 controls learning [doi:10.1126/science.aaz3136] (IsSupplementTo)
Funding DFG, LA 3442/2-1
DFG, EXC 257 NeuroCure
DFG, DFG.327654276 (SFB 1315)
EU, EU, EU.720270 (HBP SGA1)
EU, EU.785907 (HBP SGA2)
EU, EU.945539 (HBP SGA3)
EU, EU.670118 (Active Cortex)
Einstein Stiftung, EVF-2017-363
EMBO, ALTF 75-2014
NSERC, RGPIN-2017-06872
CIHR, RN383647–418955
Keywords Systems Neuroscience
Electrophysiology
Behavior
Learning and memory
Neocortex
Primary somatosensory cortex (S1)
Dendrites
L5 pyramidal neuron
Perirhinal cortex
Layer 1
Resource Type Dataset