Dataset_Doron_Shin_et_al_PRhL1_Science_2020/Figure 3

Data for Figure 3

Fig. 3A-B.mat

Z-scored firing rate of L5 pyramidal neurons in expert and naive rats during the microstimulation task. Normalized by responses during pre-stimulus period [-1 0] s.

Conditions

Condition	Description
Expert	Animals after >3 days of training.
Naive	Animals without pairing sessions.

Entries

Entry	Description
<cond>_PSTHz	Z-scores of firing rate responses.
<cond>_sorted	Index for sorting cells as in figures. Sorted by mean z-score of [0.2 0.5] s bins.
binsize	Binsize for z-scored PSTHs. 50 ms.
preStim	Pre-stimulus window. 1 s.
postStim	Post-stimulus window. 3 s.

Fig. 3C.mat

PSTHs of three distinctive subpopulations of L5 pyramidal neurons in expert rats. [cellNum x binNum] binsize: 100 ms pre-stimulus window: [-2 0] s post-stimulus window: [0 2] s

Conditions

Condition	Description
ON	Cells with post-stimulus firing rate in [0.3 0.4] s period above mean + 3 x standard deviation (SD).
OFF	Cells with post-stimulus firing rate in [0.3 0.4] s period below mean - 3 x standard deviation (SD).
NR	Rest of the cells.

Entries

Entry	Description
<cond>_PSTH	PSTHs of firing rate responses.
<cond>_bPSTH	PSTHs of burst rate responses.

Fig. 3G.mat

Motion-corrected peri-stimulus calcium transients (ΔF/F0) of three distinctive subpopulations of L5 apical dendrites in expert mice. Frame rate at 58.62 Hz. Pre-stimulus 1 s and post-stimulus 3.1 s window.

Conditions

Condition	Description
ON	Dendrites with post-stimulus calcium transients above mean + 3 x standard deviation (SD).
OFF	Dendrites with post-stimulus calcium transients below mean - 3 x standard deviation (SD).
NR	Rest of the dendrites.

Fields

Field	Description
avgTrace	Average peri-stimulus calcium traces (ΔF/F0) for each dendrite.

Fig. 3I&J.mat

Effects of optogenetic and pharmacological manipulations of dendritic activity on learning of the microstimulation detection task.

Conditions

Condition	Description
Ctrl	Animals after pairing sessions. No virus expression, but CNO was injected into L1 of S1.
BacL1	Animals after pairing sessions. GABAb receptor agonist baclofen was applied to L1 of S1.
SST	SST-cre x ChR2 mice after pairing sessions. Somatostatin-positive interneurons were optogenetically activated by LED illumination on the surface of S1.

Entries

Entry	Description
<cond>_cumvals	The cumulative learning curve statistics for the condition. Values on row N (N=1, ... 100) represents the cumulative learning score of each animal after N trials.
<cond>	The normalized learning scores for each animal belonging to the condition.