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@@ -34,15 +34,8 @@ title: "A change of mind: globus pallidus activity and effective connectivity du
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# Additional information about the resource, e.g., a brief abstract.
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description: |
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- The basal ganglia are a group of interconnected subcortical nuclei that plays a key role in multiple motor and cognitive processes, in a close interplay with several cortical regions.
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- Two conflicting theories postulate that the basal ganglia pathways can either foster or suppress the cortico-striatal output or, alternatively, they can stabilise or destabilise the cortico-striatal circuit dynamics.
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- These different approaches significantly impact the understanding of observable behaviours and cognitive processes in healthy, as well as clinical populations.
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- We investigated the predictions of these models in healthy participants (N=28), using dynamic causal modelling of fMRI BOLD activity to estimate time- and context-dependent changes in the indirect pathway effective connectivity, in association with repetitions or changes of choice selections.
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- We used two multi-option tasks that required the participants to adapt to uncontrollable environmental changes, by performing sequential choice selections, with and without value-based feedbacks.
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- We found that, irrespective of the task, the trials that were characterised by changes in choice selections (switch trials) were associated with a neural response that mostly overlapped with a network commonly described for the encoding of uncertainty.
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- More interestingly, dynamic causal modelling and family-wise model comparison identified with high likelihood a directed causal relation from the external to the internal part of the globus pallidus (i.e. the short indirect pathway in the basal ganglia), in association with the switch trials.
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- This finding supports the hypothesis that the short indirect pathway in the basal ganglia drives instability in the network dynamics, resulting in changes in choice selection.
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+ Subject-specific model-based GLM and DCM estimations.
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keywords:
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