A change of mind: globus pallidus activity and effective connectivity during changes in choice selections

Vincenzo G. Fiore 702d1fbd9b Update 'LICENSE' 9 months ago
LICENSE 702d1fbd9b Update 'LICENSE' 9 months ago
README.md 4167bc70e8 Update 'README.md' 9 months ago
datacite.yml 30696f6e22 Update 'datacite.yml' 9 months ago
subj01MRI.zip 991f10e647 Upload files to '' 10 months ago
subj02MRI.zip 991f10e647 Upload files to '' 10 months ago
subj03MRI.zip 991f10e647 Upload files to '' 10 months ago
subj04MRI.zip 991f10e647 Upload files to '' 10 months ago
subj05MRI.zip 991f10e647 Upload files to '' 10 months ago
subj06MRI.zip 991f10e647 Upload files to '' 10 months ago
subj07MRI.zip 991f10e647 Upload files to '' 10 months ago
subj08MRI.zip 991f10e647 Upload files to '' 10 months ago
subj09MRI.zip 991f10e647 Upload files to '' 10 months ago
subj10MRI.zip 991f10e647 Upload files to '' 10 months ago
subj11MRI.zip 991f10e647 Upload files to '' 10 months ago
subj12MRI.zip 991f10e647 Upload files to '' 10 months ago
subj13MRI.zip 991f10e647 Upload files to '' 10 months ago
subj14MRI.zip 991f10e647 Upload files to '' 10 months ago
subj15MRI.zip 991f10e647 Upload files to '' 10 months ago
subj16MRI.zip 991f10e647 Upload files to '' 10 months ago
subj17MRI.zip 991f10e647 Upload files to '' 10 months ago
subj18MRI.zip 991f10e647 Upload files to '' 10 months ago
subj19MRI.zip 991f10e647 Upload files to '' 10 months ago
subj20MRI.zip 991f10e647 Upload files to '' 10 months ago
subj21MRI.zip 991f10e647 Upload files to '' 10 months ago
subj22MRI.zip 991f10e647 Upload files to '' 10 months ago
subj23MRI.zip 991f10e647 Upload files to '' 10 months ago
subj24MRI.zip 991f10e647 Upload files to '' 10 months ago
subj25MRI.zip 991f10e647 Upload files to '' 10 months ago
subj26MRI.zip 991f10e647 Upload files to '' 10 months ago
subj27MRI.zip 991f10e647 Upload files to '' 10 months ago
subj28MRI.zip 991f10e647 Upload files to '' 10 months ago

README.md

Globus_Pallidus_DCM-EJoN

Title A change of mind: globus pallidus activity and effective connectivity during changes in choice selections

Abstract The basal ganglia are a group of interconnected subcortical nuclei that plays a key role in multiple motor and cognitive processes, in a close interplay with several cortical regions. Two conflicting theories postulate that the basal ganglia pathways can either foster or suppress the cortico‐striatal output or, alternatively, they can stabilise or destabilise the cortico‐striatal circuit dynamics. These different approaches significantly impact the understanding of observable behaviours and cognitive processes in healthy, as well as clinical populations. We investigated the predictions of these models in healthy participants (N=28), using dynamic causal modelling of fMRI BOLD activity to estimate time‐ and context‐dependent changes in the indirect pathway effective connectivity, in association with repetitions or changes of choice selections. We used two multi‐option tasks that required the participants to adapt to uncontrollable environmental changes, by performing sequential choice selections, with and without value‐based feedbacks. We found that, irrespective of the task, the trials that were characterised by changes in choice selections (switch trials) were associated with a neural response that mostly overlapped with a network commonly described for the encoding of uncertainty. More interestingly, dynamic causal modelling and family‐wise model comparison identified with high likelihood a directed causal relation from the external to the internal part of the globus pallidus (i.e. the short indirect pathway in the basal ganglia), in association with the switch trials. This finding supports the hypothesis that the short indirect pathway in the basal ganglia drives instability in the network dynamics, resulting in changes in choice selection.

Content of the Repository This dataset includes all the glm contrast as described in the associated manuscript (doi:10.1111/ejn.15142) as well as the DCM estimations for the model architectures described in the study. The repository is meant to provide access to the source data to allow replication, but feel free to contact the authors if interested in a secondary analysis that would require more information.

datacite.yml
Title A change of mind: globus pallidus activity and effective connectivity during changes in choice selections
Authors Fiore,Vincenzo G.;Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029-5674, USA;ORCID:0000-0002-4865-5482
Guertler,Ann-Cathrin V.;School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA
Yu,Ju-Chi;School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA
Tatineni,Chandana C.;The Texas College of Osteopathic Medicine at University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Gu,Xiaosi;Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029-5674, USA
Description Subject-specific model-based GLM and DCM estimations.
License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) (https://creativecommons.org/licenses/by-nc-nd/4.0/)
References Fiore et al. (2021) A change of mind: globus pallidus activity and effective connectivity during changes in choice selections. Eur J Neurosci. [doi:10.1111/ejn.15142] (IsSupplementTo)
Funding NIDA, R01DA043695
NIDA, R21DA049243
NIMH, R21MH120789
NIMH, R01MH124115
NIMH, R01MH122611
Keywords Computational Neuroscience
Dynamic causal modeling
effective connectivity
Basal Ganglia
Globus Pallidus
Resource Type Dataset