Gaus_etal_2021_Neuron_numbers_decreased_in_schizophrenia/README.md

Gaus_etal_2021_Neuron_numbers_decreased_in_schizophrenia

Stereologic data accompanying the study:

Richard Gaus, Melanie Popal, Helmut Heinsen, Andrea Schmitt, Peter Falkai, Patrick R. Hof, Christoph Schmitz, Alisa Vollhardt (2021) Neuron numbers are decreased in the whole cerebral cortex and in layer V of area 24 in schizophrenia

The repository contains a table (raw_stereology_data.xlsx) with clinical characteristics and raw stereological estimates of volume, cell counts, and cell densities in the whole cerebral cortex, whole area 24, and layer V of area 24 in the brains of 13 male patients with schizophrenia and 13 age-matched male controls.

Each row in the table represents one separate hemisphere. The table contains the following columns: | Column | Description | Unit | | -------- | ----------- | -------- | | subject | Subject ID | | | code | Subject code | | | excl | * | | | excl_cgm | * | | | diagnosis | Control: 0, Patient: 1 | | | hemisphere | Left or right hemisphere | | | age | Age of subject | years | | pmi | Post-mortem interval | hours | | fix | Fixation time | days | | cgm_vol | Volume of whole CGM | cm³ | | cgm_nn | Total neuron number in whole CGM | x10⁹ | | cgm_nd | Total neuron density in whole CGM | x10⁶ / cm³ | | area24_vol | Volume of whole area 24 | cm³ | | area24_nn | Total neuron number in whole area 24 | x10⁶ | | area24_nd | Total neuron density in whole area 24 | x10⁶ / cm³ | | area24layer5_vol | Volume of layer V of area 24 | cm³ | | area24layer5_nn | Total neuron number in layer V of area 24 | x10⁶ | | area24layer5_nd | Total neuron density in layer V of area 24 | x10⁶ / cm³ | | ven_number | VEN number in layer V of area 24 | x10³ | | ven_density | VEN density in layer V of area 24 | x10³ / cm³ |

CGM: cortical gray matter; VEN: von Economo neuron *All hemispheres where columns excl / excl_cgm carry the value 1 were excluded from the statistical analysis for all outcome variables / only the CGM-related outcome variables due to missing sections.

If you plan to use this data for a publication, please inform us about it and don’t forget to cite the source of the data.