Data for Doron, Shin, et al., "Perirhinal input to neocortical layer 1 controls learning".

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Data for: "Perirhinal input to neocortical layer I controls learning"

Guy Doron, Jiyun N. Shin, Naoya Takahashi, Moritz Drüke, Christina Bocklisch, Salina Skenderi, Lisa de Mont, Maria Toumazou, Julia Ledderose, Michael Brecht, Richard Naud, and Matthew E. Larkum

If you are using this dataset, please cite the dataset and the paper (use the doi provided to obtain correct citation in your reference manager). If you are using the code, please cite the science paper.

Data is distributed under a CC-BY 4.0 license, code is distributed under a MIT license.

This repository contains behavioral, electrophysiological, functional imaging (two-photon imaging) and anatomical data that were used to generate figures in our paper "Perirhinal input to neocortical layer I controls learning" by Doron, Shin et al., 2020 (doi: 10.1126/science.aaz3136).

Abstract

Hippocampal output influences memory formation in the neocortex but this process is poorly understood because the precise anatomical location and the underlying cellular mechanisms remain elusive. Here, we show that perirhinal input, predominantly to sensory cortical layer 1 (L1), controls hippocampal-dependent associative learning. This process was marked by the emergence of distinct firing responses in defined subpopulations of L5 pyramidal neurons whose tuft dendrites receive perirhinal inputs in L1. Learning correlated with burst firing and enhancement of dendritic excitability and was suppressed by disruption of dendritic activity. Furthermore, bursts, but not regular spike trains, were sufficient to retrieve learned behavior. We conclude that hippocampal information arriving at L5 tuft dendrites in neocortical L1 mediates memory formation in the neocortex.

Each figure folder contains pre-processed data (.mat or .xlsx files) to reproduce corresponding figures.
The details of the data are documented in README.md inside the folders.
Codes folder contains relevant codes used in this study.
In the Text_export folder, you will find spreadsheet that were created by exporting the .mat files into .tsv files, each file got described shortly in the 001_file_index.tsv file. It was mostly done automatically via a R script availabe in the codes folder

datacite.yml
Title	Perirhinal input to neocortical layer 1 controls learning
Authors	Doron,Guy;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-1252-5747 Shin,Jiyun N.;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-0534-6938 Takahashi,Naoya;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-6008-4627 Drüke,Moritz;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-6787-9377 Bocklisch,Christina;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: Skenderi,Salina;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-4779-4541 de Mont,Lisa;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-3829-0712 Toumazou,Maria;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: Ledderose,Julia;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0001-5458-6287 Brecht,Michael;Institut für Biologie, House 6, Philippstr. 13, Humboldt Universität, Berlin, 10115 Germany.;ORCID: 0000-0002-5387-0953 Naud,Richard;uOttawa Brain and Mind Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.;ORCID: 0000-0001-7383-3095 Larkum,Matthew E.;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0001-9799-2656
Description	This repository contains behavioral, electrophysiological, functional imaging (two-photon imaging) and anatomical data that support our findings on the functional role of perirhinal input to neocortical layer 1 on learning.
License	Creative Commons Attribution 4.0 International Public License (https://creativecommons.org/licenses/by/4.0/)
References	PublicationName1 [doi:10.xxx/zzzz] (IsSupplementTo) PublicationName2 [arxiv:mmmm.nnnn] (IsSupplementTo) PublicationName3 [pmid:nnnnnnnn] (IsReferencedBy)
Funding	DFG, EXC 257 NeuroCure DFG, DFG.327654276 (SFB 1315) EU, EU.785907 (HBP SGA2) EU, EU.670118 (Active Cortex) NSERC, Discovery grant CIHR, Project grant
Keywords	Neuroscience Electrophysiology Behavior Learning and memory Neocortex Dendrites L5 pyramidal neuron Perirhinal cortex Layer 1
Resource Type	Dataset

README.md

Data for: "Perirhinal input to neocortical layer I controls learning"

Abstract

Contents