Dataset_Doron_Shin_et_al_PRhL1_Science_2020/Figure 1

Data for Figure 1

Fig. 1C.mat

Calcium responses of perirhinal axons in layer 1 of S1 to microstimulation before and after the first training session. Pooled trials from all animals (n=3). 5-sec recording at 30 Hz, and stimulation occurred at 2 seconds.

Entry	Description
prePSTCa	Baseline-subtracted ∆F/F responses before the training
postPSTCa	Baseline-subtracted ∆F/F responses after the training
rewardPSTCa	Baseline-subtracted ∆F/F responses to reward alone

Fig. 1E.mat

Excitatory postsynaptic currents (EPSCs) of S1 neurons in response to optogenetic activation of perirhinal axons in layer 1 of S1. See Fig. S4 for individual cell responses.

Entry	Description
preCNO	EPSCs before CNO application
postCNO	EPSCs after CNO application

Fig.1F

Distribution of PRh projection in S1. Normalized signal distribution was measured along the neocortical depths.

For each file, the entry *Depth represents the binned absolute depths of the neocortex. The entry norm_* contains the normalized signals in the bins, where each column corresponds to the data from a brain section.

Files

File name	Description
ChicagoBlue.mat	Intensity of ChicagoBlue in S1 after injection in mouse S1.
MouseYFP.mat	Intensity of YFP (axon terminals) after injection of rAAV was in mouse PRh.
RatYFP.mat	Intensity of YFP (axon terminals) after injection of rAAV was in rat PRh.

Fig. 1G&H.mat

Effects of DREADD inhibition of PRh inputs to L1 of S1 on learning of the microstimulation detection task.

Conditions

Condition	Description
Untrained	Animals without any prior experience of pairing. No virus was expressed. No drug injection was performed.
Ctrl	Animals after pairing sessions. No virus expression, but CNO was injected into L1 of S1.
Dreadd	Animals after pairing sessions. Virus was expressed in PRh, and CNO was injected into L1 of S1 before testing of the learning.
Expert_preCNO	Animals being fully trained with the task. Virus was expressed in PRh. Data was obtained before injection of CNO into L1 of S1.
Expert_postCNO	Animals being fully trained with the task. Virus was expressed in PRh. Data was obtained after injection of CNO into L1 of S1.

Entries

Entry	Description
<cond>_cumvals	The cumulative learning curve statistics for the condition. Values on row N (N=1, ... 100) represents the cumulative learning score of each animal after N trials.
<cond>	The normalized learning scores for each animal belonging to the condition.