Browse Source

Update 'Figure 1/README.md'

Jiyun Shin 3 years ago
parent
commit
94cbe75971
1 changed files with 21 additions and 20 deletions
  1. 21 20
      Figure 1/README.md

+ 21 - 20
Figure 1/README.md

@@ -2,47 +2,48 @@
 
 ## Fig. 1C.mat
 
-Calcium responses(?) of dendrites(?) of S1 layer 5 neurons to microstimulation(?) before and after pairing(?). Representative session from an animal(?). 5-sec recording at 30 Hz, and stimulation occurred at 2 seconds.
+Calcium responses of perirhinal axons in layer 1 of S1 to microstimulation before and after the first training session. Pooled trials from all animals (n=3). 5-sec recording at 30 Hz, and stimulation occurred at 2 seconds.
 
-| Entry       | Description                                          |
-| ----------- | ---------------------------------------------------- |
-| `prePSTCa`  | Baseline-subtracted ∆F/F responses before pairing(?) |
-| `postPSTCa` | Baseline-subtracted ∆F/F responses after pairing(?)  |
+| Entry         | Description                                          |
+| ------------- | ---------------------------------------------------- |
+| `prePSTCa`    | Baseline-subtracted ∆F/F responses before the training |
+| `postPSTCa`   | Baseline-subtracted ∆F/F responses after the training  |
+| `rewardPSTCa` | Baseline-subtracted ∆F/F responses to reward alone  |
 
 ## Fig. 1E.mat
 
-Calcium responses(?) of dendrites(?) to microstimulation(?) before and after pharmacogenetic inhibition of PRh inputs in L1 of S1. The baseline-subtracted ∆F/F responses during the 1-second period after stimulation was averaged for each trunk. Average values for individual animals are deposited.
+Excitatory postsynaptic currents (EPSCs) of S1 neurons in response to optogenetic activation of perirhinal axons in layer 1 of S1. See Fig. S4 for individual cell responses.
 
-| Entry     | Description                              |
-| --------- | ---------------------------------------- |
-| `preCNO`  | Average responses before CNO application |
-| `postCNO` | Average responses after CNO application  |
+| Entry     | Description                  |
+| --------- | ---------------------------- |
+| `preCNO`  | EPSCs before CNO application |
+| `postCNO` | EPSCs after CNO application  |
 
 ## Fig.1F
 
-Distribution of PRh projection in S1. Normalized signal distribution was measured along the neocortical thickness.
+Distribution of PRh projection in S1. Normalized signal distribution was measured along the neocortical depths.
 
-For each file, the entry `*Depth` represents the binning borders in terms of the normalized depth along the full thickness of the neocortex. The entry `norm_*` contains the normalized signals in the bins, where each column corresponds to the data from an animal(?).
+For each file, the entry `*Depth` represents the binned absolute depths of the neocortex. The entry `norm_*` contains the normalized signals in the bins, where each column corresponds to the data from a brain section.
 
 ### Files
 
-| File name       | Description                                        |
-| --------------- | -------------------------------------------------- |
-| ChicagoBlue.mat | ChicagoBlue was injected into PRh of mice.         |
-| MouseYFP.mat    | YFP-expressing rAAV was injected into PRh of mice. |
-| RatYFP.mat      | YFP-expressing rAAV was injected into PRh of rats. |
+| File name       | Description                                                                 |
+| --------------- | --------------------------------------------------------------------------- |
+| ChicagoBlue.mat | Intensity of ChicagoBlue in S1 after injection in mouse S1.                 |
+| MouseYFP.mat    | Intensity of YFP (axon terminals) after injection of rAAV was in mouse PRh. |
+| RatYFP.mat      | Intensity of YFP (axon terminals) after injection of rAAV was in rat PRh.   |
 
 ## Fig. 1G&H.mat
 
-Effects of pharmacogenetic inhibition of PRh inputs in L1 of S1 on learning of an animal.
+Effects of DREADD inhibition of PRh inputs to L1 of S1 on learning of the microstimulation detection task.
 
 ### Conditions
 
 | Condition      | Description                                                  |
 | -------------- | ------------------------------------------------------------ |
 | Untrained      | Animals without any prior experience of pairing. No virus was expressed. No drug injection was performed. |
-| Ctrl           | Animals after several pairings. Virus was expressed in PRh, but no drug injection was performed (or vehicle was injected?). |
-| Dreadd         | Animals after several pairings. Virus was expressed in PRh, and CNO was injected into L1 of S1 before testing of the learning. |
+| Ctrl           | Animals after pairing sessions. No virus expression, but CNO was injected into L1 of S1. |
+| Dreadd         | Animals after pairing sessions. Virus was expressed in PRh, and CNO was injected into L1 of S1 before testing of the learning. |
 | Expert_preCNO  | Animals being fully trained with the task. Virus was expressed in PRh. Data was obtained before injection of CNO into L1 of S1. |
 | Expert_postCNO | Animals being fully trained with the task. Virus was expressed in PRh. Data was obtained after injection of CNO into L1 of S1. |