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Calcium responses of perirhinal axons in layer 1 of S1 to microstimulation before and after the first training session. Pooled trials from all animals (n=3). 5-sec recording at 30 Hz, and stimulation occurred at 2 seconds.
Entry | Description |
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prePSTCa |
Axonal calcium responses (∆F/F) to microstimualtion before the training. |
postPSTCa |
Axonal calcium responses (∆F/F) to microstimualtion after the training. |
rewardPSTCa |
Axonal calcium responses (∆F/F) responses to reward alone. |
Excitatory postsynaptic currents (EPSCs) of S1 neurons in response to optogenetic activation of perirhinal axons in layer 1 of S1. See Fig. S4 for individual cell responses.
Entry | Description |
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preCNO |
EPSCs before CNO application |
postCNO |
EPSCs after CNO application |
Distribution of PRh projection in S1. Normalized signal distribution was measured along the neocortical depths.
For each file, the entry *Depth
represents the binned absolute depths of the neocortex. The entry norm_*
contains the normalized signals in the bins, where each column corresponds to the data from a brain section.
File name | Description |
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ChicagoBlue.mat | Intensity of ChicagoBlue in S1 after injection in mouse S1. |
MouseYFP.mat | Intensity of YFP (axon terminals) after injection of rAAV was in mouse PRh. |
RatYFP.mat | Intensity of YFP (axon terminals) after injection of rAAV was in rat PRh. |
Effects of DREADD inhibition of PRh inputs to L1 of S1 on learning of the microstimulation detection task.
Condition | Description |
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Untrained | Animals without any prior experience of pairing. No virus was expressed. No drug injection was performed. |
Ctrl | Animals after pairing sessions. No virus expression, but CNO was injected into L1 of S1. |
Dreadd | Animals after pairing sessions. Virus was expressed in PRh, and CNO was injected into L1 of S1 before testing of the learning. |
Expert_preCNO | Animals being fully trained with the task. Virus was expressed in PRh. Data was obtained before injection of CNO into L1 of S1. |
Expert_postCNO | Animals being fully trained with the task. Virus was expressed in PRh. Data was obtained after injection of CNO into L1 of S1. |
Entry | Description |
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<cond>_cumvals |
The cumulative learning curve statistics for the condition. Values on row N (N=1, ... 100) represents the cumulative learning score of each animal after N trials. |
<cond> |
The normalized learning scores for each animal belonging to the condition. |
datacite.yml | |
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Title | Perirhinal input to neocortical layer 1 controls learning |
Authors |
Doron,Guy;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-1252-5747
Shin,Jiyun N.;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-0534-6938 Takahashi,Naoya;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany. Present address: University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, 33000 Bordeaux,France.;ORCID: 0000-0002-6008-4627 Drüke,Moritz;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-6787-9377 Bocklisch,Christina;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: Skenderi,Salina;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-4779-4541 de Mont,Lisa;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-3829-0712 Toumazou,Maria;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: Ledderose,Julia;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0001-5458-6287 Colomb,Julien;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-3127-5520 Sehara,Keisuke;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-4368-8143 Brecht,Michael;Bernstein Center for Computational Neuroscience, House 6, Philippstr. 13, Humboldt Universität, Berlin, 10115 Germany. NeuroCure Cluster, Charité - Universitätsmedizin Berlin, D-10117 Berlin, Germany.;ORCID: 0000-0002-5387-0953 Naud,Richard;University of Ottawa Brain and Mind Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada. Department of Physics, University of Ottawa, Ottawa, ON K1N 6N5, Canada;ORCID: 0000-0001-7383-3095 Larkum,Matthew E.;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0001-9799-2656 |
Description | This repository contains behavioral, electrophysiological, functional imaging (two-photon imaging) and anatomical data that support our findings on the functional role of perirhinal input to neocortical layer 1 on learning. |
License | Creative Commons Attribution 4.0 International Public License (https://creativecommons.org/licenses/by/4.0/) |
References |
Perirhinal input to neocortical layer 1 controls learning [doi:10.1126/science.aaz3136] (IsSupplementTo)
|
Funding |
DFG, LA 3442/2-1
DFG, EXC 257 NeuroCure DFG, DFG.327654276 (SFB 1315) EU, EU, EU.720270 (HBP SGA1) EU, EU.785907 (HBP SGA2) EU, EU.945539 (HBP SGA3) EU, EU.670118 (Active Cortex) Einstein Stiftung, EVF-2017-363 EMBO, ALTF 75-2014 NSERC, RGPIN-2017-06872 CIHR, RN383647–418955 |
Keywords |
Systems Neuroscience
Electrophysiology Behavior Learning and memory Neocortex Primary somatosensory cortex (S1) Dendrites L5 pyramidal neuron Perirhinal cortex Layer 1 |
Resource Type |
Dataset |