We use cookies to ensure you get the best experience on our website
Accueil Explorer Aide News
S'inscrire Connexion

Scheduled service maintenance on November 22

On Friday, November 22, 2024, between 06:00 CET and 18:00 CET, GIN services will undergo planned maintenance. Extended service interruptions should be expected. We will try to keep downtimes to a minimum, but recommend that users avoid critical tasks, large data uploads, or DOI requests during this time.

We apologize for any inconvenience.

xiaxiaxu
/
Developmental_ephys_LEC-HP-PFC
DOI
10.12751/g-node.sld1d2
1
0
Fork 1
Fichiers Tickets 0 Pull Requests 0 Wiki

This repository contains the ephys data related to the article " Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice ". We provide optogenetic in vivo recordings of LEC, HP, PFC in non-anesthetized and urethane-anesthetized mice of control and GE mice in the right hemisphere.

Aborescence: d0edec1a7d
Branches Tags
Developmenta...
Xiaxia d0edec1a7d 更新 'datacite.yml' il y a 3 ans
2021-05-10_19-08-50 f38198ea7a 上传文件至 '' il y a 3 ans
Behavior 9973a2dacd 上传文件至 'Behavior' il y a 3 ans
Histology 70cab8400d 上传文件至 'Histology' il y a 3 ans
LEC_terminalChR_HP 59d2068539 上传文件至 'LEC_terminalChR_HP' il y a 3 ans
SUA ce75a6e993 上传文件至 'SUA' il y a 3 ans
eOPN3 5d54a0fde0 上传文件至 'eOPN3' il y a 3 ans
LICENSE a0b7312c12 上传文件至 '' il y a 3 ans
README.md 4c2ce12495 Initial commit il y a 3 ans
datacite.yml d0edec1a7d 更新 'datacite.yml' il y a 3 ans

README.md

Developmental_ephys_LEC-HP-PFC

This repository contains the ephys data related to the article " Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice ". We provide optogenetic in vivo recordings of LEC, HP, PFC in non-anesthetized and urethane-anesthetized mice of control and GE mice in the right hemisphere.

datacite.yml
Title Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice
Authors Xu,Xiaxia;University Medical Center Hamburg-Eppendorf
Song,Lingzhen;University Medical Center Hamburg-Eppendorf
Kringel,Rebecca;University Medical Center Hamburg-Eppendorf
Hanganu-Opatz,Ileana L;University Medical Center Hamburg-Eppendorf
Description The prefrontal-hippocampal dysfunction that underlies cognitive deficits in mental disorders emerges during early development. The lateral entorhinal cortex (LEC) is tightly interconnected with both prefrontal cortex (PFC) and hippocampus (HP), yet its contribution to the early dysfunction is fully unknown. Here we show that mice that mimic the dual genetic (G) -environmental (E) etiology (GE mice) of psychiatric risk have poor LEC-dependent recognition memory at pre-juvenile age and abnormal communication within LEC-HP-PFC networks throughout development. These functional and behavioral deficits relate to sparser projections from LEC to CA1 and decreased efficiency of axonal terminals to activate the hippocampal circuits in neonatal GE mice. In contrast, the direct entorhinal drive to PFC is not affected, yet the PFC is indirectly compromised, as target of the under-activated HP. Thus, the entorhinal-hippocampal circuit is already impaired from neonatal age on in GE mice.
License Creative Commons CC0 1.0 Universal (http://creativecommons.org/publicdomain/zero/1.0)
References Xiaxia Xu, Lingzhen Song, Rebecca Kringel et al. Developmental decrease of entorhinal gate disrupts prefrontal-hippocampal communication in immune-challenged DISC1 knockdown mice, 10 March 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-290304/v1] [https://doi.org/10.21203/RS.3.RS-290304/V1] (IsSupplementTo)
Funding DFG, SFB 936 B5 and Ha4466/11-1 to I.L.H.-O
EU, ERC-2015-CoG 681577 to I.L.H.-O.
Keywords Neuroscience
LEC
DISC1
Resource Type Dataset