This repository contains the data and models underlying the analyses published in Oesterle, Ran et al. (2024)

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s-on-alpha-regional

This repository contains the data and models underlying the analyses published in Oesterle, Ran et al. (2024): "Task-specific regional circuit adaptations in distinct mouse retinal ganglion cells". This work provides evidence support that the mouse retina shows regional adaptations in signal processing, enhancing their ability to detect prey during hunting.“

Repository structure

The repository contains two sub-directories holding the data and code, respectively, which are structured as outlined below.

Data

The relevant data can be found in the data folder.

data/Ran contains the dendritic data, for both calcium and glutamate imaging.
data/Oesterle contains somatic calcium recordings.
data/Stimulus contains the necessary stimuli (e.g. the dense noise stimulus to compute receptive fields).

Code

The code can be found in the code folder; it's published under the MIT license. First, install all packages and their requirements (in case of the model only if you want to use it).

To preprocess the data follow the instructions in code/AlphaDjimaging.
To recreate the analysis and figure panels follow the instructions in code/AlphaAnalysis.
To train and evaluate the model follow the instructions in code/AlphaCNN.
To create figures from figure panels use the Inkscape files in code/AlphaFigures.

Authors and acknowledgements

See acknowledgments section in Oesterle, Ran et al. (2024).

datacite.yml
Title	Task-specific regional circuit adaptations in distinct mouse retinal ganglion cells
Authors	Oesterle,Jonathan;Institute for Ophthalmic Research, University of Tübingen, Germany; Hertie Institute for AI in Brain Health, University of Tübingen, Tübingen, Germany;ORCID:0000-0001-8919-1445 Ran,Yanli;Institute for Ophthalmic Research, University of Tübingen, Germany; Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, China Stahr,Paul;Max Planck Institute for Neurobiology of Behavior, Bonn, Germany Kerr,Jason ND;Max Planck Institute for Neurobiology of Behavior, Bonn, Germany;ORCID:0000-0001-9459-883X Schubert,Timm;Institute for Ophthalmic Research, University of Tübingen, Germany Berens,Philipp;Hertie Institute for AI in Brain Health, University of Tübingen, Tübingen, Germany;ORCID:0000-0002-0199-4727 Euler,Thomas;Institute for Ophthalmic Research, University of Tübingen, Germany;ORCID:0000-0002-4567-6966
Description	This repository contains the data, analysis pipeline, and models underlying the analyses published in Oesterle, Ran et al. Our study provides evidence that the mouse retina shows regional adaptations in signal processing, enhancing their ability to detect prey during hunting.
License	Creative Commons Attribution-NonCommercial-ShareAlike 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/)
References	Sustained ON alpha retinal ganglion cells in the temporal retina exhibit task-specific regional adaptions in dendritic signal integration [doi:10.1101/2024.03.27.586958] (IsSupplementTo)
Funding	DFG; BE 5601/6-1 DFG; BE 5601/9-1 DFG; EU 42/10-1 DFG; EU 42/12-1 NSFC; YR 32200810 MPG
Keywords	Neuroscience Retinal ganglion cells Visual ecology Regional circuit adaptations
Resource Type	Dataset

README.md

s-on-alpha-regional

Repository structure

Data

Code

Authors and acknowledgements