Studying SSA and Error Response Signals in Zebra Finch NCM

Michael Liu Happ d43a74d160 Update 'datacite.yml' 1 year ago
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Studying SSA and Error Response Signals in Zebra Finch NCM

This repository contains summary data for Michael Liu Happ's written dissertation.

Data is in a format to be used and analyzed by MATLAB code provided in each folder, and at the following GitHub link: Code at these locations should be identical.

NOTE: The analysis code written here makes use of the cortexlab-spikes toolbox, available here: That toolbox should be downloaded and added to your MATLAB path before attempting to run any analysis code from Chapters 3 or 4.

Additional information can be obtained by reading the dissertation, uploaded as Happ_Dissertation.pdf.

Title A Predictive Circuit for Novelty Detection in Songbird Auditory Cortex
Authors Happ,Michael;MIT;ORCID:0000-0001-6345-2272
Description In order to make sense of complicated sensory landscapes, the brain privileges the processing of novel stimuli. Detecting novelty is therefore a fundamental problem for the brain to solve. And it turns out to be complicated, as stimuli can be completely novel, or just novel relative to certain certain contexts or expectations. To better understand how the brain detects both types of novelty, we studied an auditory region of the avian brain that performs both absolute and relative novelty detection. We introduce a predictive model, called the Agnotron, that is capable of performing both kinds of novelty detection with the same circuit mechanism. Armed with predictions made by the Agnotron, we perform experiments to confirm the existence of Agnotron- like circuitry in the brain. While we fail to find evidence that the various novelty signals in this brain area are produced by the same mechanism, we do find support for predictive circuitry for some novelty signals. We continue with an advanced investigation of one absolute novelty signal in particular, known as the Song-Specific Adaptation. After recapitulating classical results with state-of-the-art technology, we report novel phenomena that rule out predictive circuit mechanisms for the SSA. Taken together, our results suggest that predictive mechanisms can explain some novelty signals in the avian brain, but not the SSA, which seems to have a more simplistic feed-forward mechanism of generation.
License Creative Commons CC0 1.0 Public Domain Dedication (
References Happ, Michael Liu (March 1, 2023). A predictive circuit for novelty detection in Songbird Auditory Cortex. Massachusetts Institute of Technology, Cambridge, MA, USA. [doi:tba] (IsSupplementTo)
Keywords Neuroscience
Resource Type Dataset