|
@@ -15,24 +15,24 @@ authors:
|
|
|
firstname: "Nicolas W."
|
|
|
lastname: "Schuck"
|
|
|
affiliation: "Max Planck Institute for Human Development, Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany"
|
|
|
- id: "ResearcherID:X-1234-5678"
|
|
|
+ id: "ORCID:0000-0002-0150-8776"
|
|
|
|
|
|
# A title to describe the published resource.
|
|
|
-title: "Faster than thought: Detecting sub-second activation sequences with sequential fMRI pattern analysis"
|
|
|
+title: "Dynamics of fMRI patterns reflect sub-second activation sequences and reveal replay in human visual cortex - BIDS dataset"
|
|
|
|
|
|
# Additional information about the resource, e.g., a brief abstract.
|
|
|
description: |
|
|
|
- Neural computations are often anatomically localized and executed on sub-second time scales.
|
|
|
- Understanding the brain therefore requires methods that offer sufficient spatial and temporal resolution.
|
|
|
- This poses a particular challenge for the study of the human brain because non-invasive methods have either high temporal or spatial resolution, but not both.
|
|
|
- Here, we introduce a novel multivariate analysis method for conventional blood-oxygen-level dependent functional magnetic resonance imaging (BOLD fMRI) that allows to study sequentially activated neural patterns separated by less than 100 ms with anatomical precision.
|
|
|
- Human participants underwent fMRI and were presented with sequences of visual stimuli separated by 32 to 2048 ms.
|
|
|
- Probabilistic pattern classifiers were trained on fMRI data to detect the presence of image-specific activation patterns in early visual and ventral temporal cortex.
|
|
|
- The classifiers were then applied to data recorded during sequences of the same images presented at increasing speeds.
|
|
|
- Our results show that probabilistic classifier time courses allowed to detect neural representations and their order, even when images were separated by only 32 ms.
|
|
|
- Moreover, the frequency spectrum of the statistical sequentiality metric distinguished between sequence speeds on sub-second versus supra-second time scales.
|
|
|
- These results survived when data with high levels of noise and rare sequence events at unknown times were analyzed.
|
|
|
- Our method promises to lay the groundwork for novel investigations of fast neural computations in the human brain, such as hippocampal replay.
|
|
|
+ Neural computations are often fast and anatomically localized.
|
|
|
+ Yet, investigating such computations in humans is challenging because non-invasive methods have either high temporal or spatial resolution, but not both.
|
|
|
+ Of particular relevance, fast neural replay is known to occur throughout the brain in a coordinated fashion about which little is known.
|
|
|
+ We develop a multivariate analysis method for functional magnetic resonance imaging that makes it possible to study sequentially activated neural patterns separated by less than 100 ms with precise spatial resolution.
|
|
|
+ Human participants viewed images individually and sequentially with speeds up to 32 ms between items.
|
|
|
+ Probabilistic pattern classifiers were trained on activation patterns in visual and ventrotemporal cortex during individual image trials.
|
|
|
+ Applied to sequence trials, probabilistic classifier time courses allow the detection of neural representations and their order.
|
|
|
+ Order detection remains possible at speeds up to 32 ms between items.
|
|
|
+ The frequency spectrum of the sequentiality metric distinguishes between sub- versus supra-second sequences.
|
|
|
+ Importantly, applied to resting-state data our method reveals fast replay of task-related stimuli in visual cortex.
|
|
|
+ This indicates that non-hippocampal replay occurs even after tasks without memory requirements and shows that our method can be used to detect such spontaneously occurring replay.
|
|
|
|
|
|
# Lit of keywords the resource should be associated with.
|
|
|
# Give as many keywords as possible, to make the resource findable.
|
|
@@ -54,7 +54,8 @@ license:
|
|
|
# Funding information for this resource.
|
|
|
# Separate funder name and grant number by comma.
|
|
|
funding:
|
|
|
- - "Max Planck Society (M.TN.A.BILD0004)"
|
|
|
+ - "Max Planck Society, Independent Max Planck Research Group grant"
|
|
|
+ - "European Union, ERC Starting Grant ERC-2019-StG REPLAY-852669"
|
|
|
- "Max Planck Institute for Human Development"
|
|
|
|
|
|
|
|
@@ -68,6 +69,9 @@ references:
|
|
|
id: "doi:10.1101/2020.02.15.950667"
|
|
|
reftype: "IsSupplementTo"
|
|
|
citation: "Wittkuhn, L. and Schuck, N. W. (2020). Faster than thought: Detecting sub-second activation sequences with sequential fMRI pattern analysis. bioRxiv. doi:10.1101/2020.02.15.950667"
|
|
|
+ -
|
|
|
+ reftype: "IsSupplementTo"
|
|
|
+ citation: "Wittkuhn, L. and Schuck, N. W. (2020). Faster than thought: Detecting sub-second activation sequences with sequential fMRI pattern analysis. bioRxiv. doi:10.1101/2020.02.15.950667"
|
|
|
|
|
|
|
|
|
|