SSVEP_Lrrk2

SSVEP_Lrrk2

Steady-state VEP data recorded in female Lrrk2-KO (n=15) or WT rats (n=14). Electrodes were steel screws located bilaterally over the visual cortex and superior colliculus,recording local field potentials. The recordings were made in Spike 2, the data provided here has been exported to the .mat format which can be loaded into matlab.

(data is used for the paper: Knocking out the LRRK2 gene increases sensitivity to wavelength information in the rat, Østergaard)

• WT animals have the numbers: 1,3,6,9,11,13,15,16,18,19,20,22,24,26,28
• KO animals have the numbers: 2,4,5,7,8,10,12,14,17,21,23,25,27,29

Structure of repository

The data is divided into colour test and PFE360. The PFE360 is further divided into first_dose and cross-over.

• The colour test: five different wavelengths were applied to a 10 ms flash of light presented at a rate of 14 Hz. The wavelengths were: short-wave blue (SWB) here denoted UV (405 nm), blue (455-460 nm), green (525-530 nm), red (620-625 nm) and white 5050 SMD LEDs.

• PFE360: PFE360 is a LRRK2 kinase inhibitor it was dosed at a concentration of 7.5 mg/kg in a cross-over design. The randomisation sequence was - 0,1,1,1,1,0,1,0,0,0,0,1,1,0,0,1,0,1,0,0,0,0,1,0,1,1,1,1,1 on first dose 0=vehicle and 1=PFE360 and vice versa for cross-over

The folder matlab scripts contain examples of scipts for preprocessing SSVEP data as spectra using Accusleep source code.