NBM-ACh-Coordinated_Learning/datacite.yml

authors:
  -
    firstname: 'Yue'
    lastname: 'Li'
    affiliation: 'Burke Neurological Institute'
    id: 'ORCID:0000-0002-9594-5802'
  -
    firstname: 'Edmund'
    lastname: 'Hollis'
    affiliation: 'Burke Neurological Institute'
    id: 'ORCID:0000-0002-4535-4668'
title: 'Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice'
description: "Motor control requires precise temporal and\nspatial encoding across distinct motor centers that is refined through the\nrepetition of learning. The recruitment of motor regions requires modulatory\ninput to shape circuit activity. Here we identify a role for the baso-cortical cholinergic\npathway in the acquisition of a coordinated motor skill in mice. Targeted\ndepletion of basal forebrain cholinergic neurons results in significant impairments\nin training on the rotarod task of coordinated movement. Cholinergic\nneuromodulation is required during training sessions as chemogenetic\ninactivation of cholinergic neurons also impairs task acquisition. Rotarod\nlearning is known to drive refinement of corticostriatal neurons arising in both\nmedial prefrontal cortex (mPFC) and motor cortex, and we have found that\ncholinergic input to both motor regions is required for task acquisition. Critically,\nthe effects of cholinergic neuromodulation are restricted to the acquisition\nstage, as depletion of basal forebrain cholinergic neurons after learning does\nnot affect task execution. Our\nresults indicate a critical role for cholinergic neuromodulation of distant cortical\nmotor centers during coordinated motor learning."
keywords:
  - 'Basal forebrain'
  - 'Cholinergic neurons'
  - 'Motor learning'
  - 'Coordination'
  - 'Rotarod'
  - 'Forelimb reach'
  - 'Prefrontal cortex'
  - 'Motor cortex'
license:
  name: 'Creative Commons CC0 1.0 Public Domain Dedication'
  url: 'https://creativecommons.org/publicdomain/zero/1.0/'
funding:
  - 'Burke foundation'
  - 'NIH, DP2 NS106663'
  - 'New York State Department of Health SCIRB, C32633GG'
references:
  -
    id: 'doi:pending'
    id: 'pmid:pending'
    reftype: IsSupplementTo
    citation: Li and Hollis (in press). Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice. J Neurosci.
resourcetype: Dataset
templateversion: 1.2