| Title |
Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice |
| Authors |
Li,Yue;Burke Neurological Institute;ORCID:0000-0002-9594-5802
Hollis,Edmund;Burke Neurological Institute;ORCID:0000-0002-4535-4668
|
| Description |
Motor control requires precise temporal and
spatial encoding across distinct motor centers that is refined through the
repetition of learning. The recruitment of motor regions requires modulatory
input to shape circuit activity. Here we identify a role for the baso-cortical cholinergic
pathway in the acquisition of a coordinated motor skill in mice. Targeted
depletion of basal forebrain cholinergic neurons results in significant impairments
in training on the rotarod task of coordinated movement. Cholinergic
neuromodulation is required during training sessions as chemogenetic
inactivation of cholinergic neurons also impairs task acquisition. Rotarod
learning is known to drive refinement of corticostriatal neurons arising in both
medial prefrontal cortex (mPFC) and motor cortex, and we have found that
cholinergic input to both motor regions is required for task acquisition. Critically,
the effects of cholinergic neuromodulation are restricted to the acquisition
stage, as depletion of basal forebrain cholinergic neurons after learning does
not affect task execution. Our
results indicate a critical role for cholinergic neuromodulation of distant cortical
motor centers during coordinated motor learning.
|
| License |
Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
|
| References |
Li and Hollis (in press). Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice. J Neurosci. [pmid:pending] (IsSupplementTo)
|
| Funding |
Burke foundation
NIH, DP2 NS106663
New York State Department of Health SCIRB, C32633GG
|
| Keywords |
Basal forebrain
Cholinergic neurons
Motor learning
Coordination
Rotarod
Forelimb reach
Prefrontal cortex
Motor cortex
|
| Resource Type |
Dataset
|
