Source data Manuscript ref.# NCOMMS-21-49031
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| Blots images_NCMM.zip | 1 năm trước cách đây | |
| LICENSE | 1 năm trước cách đây | |
| README.md | 1 năm trước cách đây | |
| Source Data.xlsx | 1 năm trước cách đây | |
| datacite.yml | 1 năm trước cách đây |
We provide a single Excel file named Source Data with raw data for each figure, in a separate labelled sheet, as well as a zipped folder named Blots images_NCMM comprising the uncropped versions of blots corresponding to Fig.2 and Suppl. Fig.1 included in the Manuscript "Kisspeptin signaling in astrocytes centrally modulates the reproductive axis" authored E. Torres, G. Pellegrino, I. Velasco, A.C. Fuentes-Fayos, M. Granados-Rodríguez, A. Coutteau-Robles, A. Legrand, C. Perdices-Lopez, S. Leon, S.H. Yeo, S.M. Manchishi, M.J. Sánchez-Tapia, R. Pineda, J. Roa, J. Argente, R.M. Luque, V. Prevot, J. Chowen, A. Sharif, W.H. Colledge, M. Tena-Sempere, A. Romero-Ruiz. (* Equal senior and corresponding authors).
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| Title | Kisspeptin signaling in astrocytes centrally modulates the reproductive axis |
| Authors |
Torres,Encarnacion;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC),
Córdoba, Spain; Department of Cell Biology, Physiology and Immunology,
University of Córdoba, Córdoba, Spain; Hospital Universitario Reina
Sofía, Córdoba, Spain ;ORCID:0000-0001-9077-6504
Pellegrino,Giulliana;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Velasco,Inmaculada;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Fuentes-Fayos,Antonio Carlos;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Granados-Rodriguez,Melissa;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Coutteau-Robles,Adrián;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Legrand,Amandine;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Perdices-Lopez,Cecilia;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Leon,Silvia;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Yeo,Shel H;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK Manchishi,Stephen;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK Sanchez-Tapia,María Jesús;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Pineda,Rafael;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Roa,Juan;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain Argente,Jesús;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain Luque,Raúl M.;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain Prevot,Vicent;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Chowen,Julie;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain Sharif,Ariane;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Colledge,William H.;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK Tena-Sempere,Manuel;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Institute of Biomedicine, University of Turku, Finland Romero,Antonio;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain |
| Description | Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin signaling, via Kiss1r, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a pathway for direct kisspeptin actions in astrocytes that contribute to central reproductive modulation. |
| License | Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/) |
| References | |
| Funding |
Agencia Estatal de Investigación, Spain; co-funded with EU funds from FEDER Program; BFY2017-83934-P
Agencia Estatal de Investigación, Spain; co-funded with EU funds from FEDER Program; PID2019-105564RB-I00 Agencia Estatal de Investigación, Spain; co-funded with EU funds from FEDER Program; PID2020-118660GB-I00 Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain; Project PIE-14-00005 ( Junta de Andalucía, Spain; Projects P12-FQM-01943 and P18-RT-4093 Universidad de Córdoba-FEDER; Project 1254821 BBSRC Project Grant, BB/K003178/1 |
| Keywords |
Kisspeptin-signaling
Astrocytes Reproduction |
| Resource Type |
Dataset |
