doi/Kisspeptin-signaling-in-astrocytes-data-source: Source data Manuscript ref.# NCOMMS-21-49031

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manuscript, ref.# NCOMMS-21-49031

We provide a single Excel file named Source Data with raw data for each figure, in a separate labelled sheet, as well as a zipped folder named Blots images_NCMM comprising the uncropped versions of blots corresponding to Fig.2 and Suppl. Fig.1 included in the Manuscript "Kisspeptin signaling in astrocytes centrally modulates the reproductive axis" authored E. Torres, G. Pellegrino·, M. Granados-Rodríguez·, A.C. Fuentes-Fayos, I. Velasco, A. Coutteau-Robles, A. Legrand, M. Shanabrough, C. Perdices-Lopez, S. Leon, S.H. Yeo, S.M. Manchishi, M.J. Sánchez-Tapia, V.M. Navarro, R. Pineda, J. Roa, F. Naftolin, J. Argente, R.M. Luque, T.L. Horvath, V. Prevot, J. Chowen, A. Sharif, W.H. Colledge, M. Tena-Sempere, A. Romero-Ruiz. (·Equally contributed and should be considered joint second authors) (* Equal senior and corresponding authors).

datacite.yml
Title	Kisspeptin signaling in astrocytes centrally modulates the reproductive axis
Authors	Torres,Encarnacion;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ;ORCID:0000-0001-9077-6504 Pellegrino,Giulliana;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Granados-Rodriguez,Melissa;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Fuentes-Fayos,Antonio Carlos;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Velasco,Inmaculada;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Coutteau-Robles,Adrián;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Legrand,Amandine;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Shanabrough,Marya;Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA Perdices-Lopez,Cecilia;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Leon,Silvia;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Yeo,Shel H;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK Manchishi,Stephen;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK Sanchez-Tapia,María Jesús;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Navarro,Victor Manuel;Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, USA Pineda,Rafael;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain Roa,Juan;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain Naftolin,Fred;Centro de Fecundacion In Vitro Angela Palumbo (FIVAP), La Laguna, Spain Argente,Jesús;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain Luque,Raúl M.;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain Chowen,Julie;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain Horvath,Tamas L.;Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA Prevot,Vicent;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Sharif,Ariane;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Colledge,William H.;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK Tena-Sempere,Manuel;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain Romero,Antonio;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain
Description	Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin signaling, via Kiss1r, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a pathway for direct kisspeptin actions in astrocytes that contribute to central reproductive modulation.
License	Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
References	E. Torres, G. Pellegrino, I. Velasco, A.C. Fuentes-Fayos, M. Granados-Rodríguez, A. Coutteau-Robles, A. Legrand, M. Shanabrough, C. Perdices-Lopez, S. Leon, S.H. Yeo, S.M. Manchishi, M.J. Sánchez-Tapia, R. Pineda, J. Roa, F. Naftolin, J. Argente, R.M. Luque, V. Prevot, J. Chowen, T.L. Horvath, A. Sharif, W.H. Colledge, M. Tena-Sempere, A. Romero-Ruiz: Kisspeptin signaling in astrocytes centrally modulates the reproductive axis [doi::tba] (IsSupplementTo)
Funding	Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program; BFY2017-83934-P Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program; PID2019-105564RB-I00 Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program; PID2020-118660GB-I00 Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain; Project PIE-14-00005 Junta de Andalucía, Spain; Projects P12-FQM-01943 and P18-RT-4093 Universidad de Córdoba-FEDER; Project 1254821 BBSRC Project Grant; BB/K003178/1
Keywords	Kisspeptin-signaling Astrocytes Reproduction
Resource Type	Dataset

datacite.yml

Title

Kisspeptin signaling in astrocytes centrally modulates the reproductive axis

Authors

Torres,Encarnacion;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ;ORCID:0000-0001-9077-6504
Pellegrino,Giulliana;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
Granados-Rodriguez,Melissa;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain
Fuentes-Fayos,Antonio Carlos;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain
Velasco,Inmaculada;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain
Coutteau-Robles,Adrián;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
Legrand,Amandine;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
Shanabrough,Marya;Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA
Perdices-Lopez,Cecilia;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain
Leon,Silvia;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain
Yeo,Shel H;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Manchishi,Stephen;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Sanchez-Tapia,María Jesús;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain
Navarro,Victor Manuel;Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
Pineda,Rafael;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain
Roa,Juan;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
Naftolin,Fred;Centro de Fecundacion In Vitro Angela Palumbo (FIVAP), La Laguna, Spain
Argente,Jesús;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain
Luque,Raúl M.;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
Chowen,Julie;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain
Horvath,Tamas L.;Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA
Prevot,Vicent;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
Sharif,Ariane;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
Colledge,William H.;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Tena-Sempere,Manuel;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
Romero,Antonio;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain

Description

Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin signaling, via Kiss1r, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a pathway for direct kisspeptin actions in astrocytes that contribute to central reproductive modulation.

License

Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)

References

E. Torres, G. Pellegrino, I. Velasco, A.C. Fuentes-Fayos, M. Granados-Rodríguez, A. Coutteau-Robles, A. Legrand, M. Shanabrough, C. Perdices-Lopez, S. Leon, S.H. Yeo, S.M. Manchishi, M.J. Sánchez-Tapia, R. Pineda, J. Roa, F. Naftolin, J. Argente, R.M. Luque, V. Prevot, J. Chowen, T.L. Horvath, A. Sharif, W.H. Colledge, M. Tena-Sempere, A. Romero-Ruiz: Kisspeptin signaling in astrocytes centrally modulates the reproductive axis [doi::tba] (IsSupplementTo)

Funding

Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program; BFY2017-83934-P
Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program; PID2019-105564RB-I00
Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program; PID2020-118660GB-I00
Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain; Project PIE-14-00005
Junta de Andalucía, Spain; Projects P12-FQM-01943 and P18-RT-4093
Universidad de Córdoba-FEDER; Project 1254821
BBSRC Project Grant; BB/K003178/1

Keywords

Kisspeptin-signaling
Astrocytes
Reproduction

Resource Type

Dataset