doi/Kisspeptin-signaling-in-astrocytes-data-source: Source data Manuscript ref.# NCOMMS-21-49031 @ 48034234191ebdbe61f1b66c2674c5e7b8f45262

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ETJ 4803423419 Update 'README.md'		1 year ago
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1 year ago

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LICENSE

993494b98e Initial commit

1 year ago

README.md

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datacite.yml

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manuscript, ref.# NCOMMS-21-49031

We provide a single Excel file named Source Data with raw data for each figure, in a separate labelled sheet, as well as a zipped folder named Blots images_NCMM comprising the uncropped versions of blots corresponding to Fig.2 and Suppl. Fig.1 included in the Manuscript "Kisspeptin signaling in astrocytes centrally modulates the reproductive axis" authored E. Torres, G. Pellegrino, I. Velasco, A.C. Fuentes-Fayos, M. Granados-Rodríguez, A. Coutteau-Robles, A. Legrand, C. Perdices-Lopez, S. Leon, S.H. Yeo, S.M. Manchishi, M.J. Sánchez-Tapia, R. Pineda, J. Roa, J. Argente, R.M. Luque, V. Prevot, J. Chowen, A. Sharif, W.H. Colledge, M. Tena-Sempere, A. Romero-Ruiz. (* Equal senior and corresponding authors).

datacite.yml
Title	Kisspeptin signaling in astrocytes centrally modulates the reproductive axis
Authors	Torres,Encarnacion;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain. Pellegrino,Giulliana;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Velasco,Inmaculada;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain. Fuentes-Fayos,Antonio Carlos;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain. Granados-Rodriguez,Melissa;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain. Coutteau-Robles,Adrián;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Legrand,Amandine;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Perdices-Lopez,Cecilia;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain. Leon,Silvia;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain. Yeo,Shel H;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. Manchishi,Stephen;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. Sanchez-Tapia,María Jesús;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain. Pineda,Rafael;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain. Roa,Juan;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain. Argente,Jesús;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain. Luque,Raúl M.;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain. Prevot,Vicent;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France. Chowen,Julie;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain. Sharif,Ariane;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France Colledge,William H.;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. Tena-Sempere,Manuel;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Institute of Biomedicine, University of Turku, Finland. Romero,Antonio;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
Description	Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin signaling, via, Kiss1r, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a pathway for direct kisspeptin actions in astrocytes that contribute to central reproductive modulation.
License	Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
References
Funding	BFY2017-83934-P (from Agencia Estatal de Investigación, Spain; co-funded with EU funds from FEDER Program) PID2019-105564RB-I00 (from Agencia Estatal de Investigación, Spain; co-funded with EU funds from FEDER Program) PID2020-118660GB-I00 (from Agencia Estatal de Investigación, Spain; co-funded with EU funds from FEDER Program) Project PIE-14-00005 (Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain) Projects P12-FQM-01943 and P18-RT-4093 (Junta de Andalucía, Spain) Project 1254821 (Universidad de Córdoba-FEDER) BBSRC Project Grant, BB/K003178/1
Keywords	Kisspeptin-signaling Astrocytes Reproduction
Resource Type	Dataset

datacite.yml

Title

Kisspeptin signaling in astrocytes centrally modulates the reproductive axis

Authors

Torres,Encarnacion;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain.
Pellegrino,Giulliana;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
Velasco,Inmaculada;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain.
Fuentes-Fayos,Antonio Carlos;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain.
Granados-Rodriguez,Melissa;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain.
Coutteau-Robles,Adrián;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
Legrand,Amandine;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
Perdices-Lopez,Cecilia;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain.
Leon,Silvia;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain.
Yeo,Shel H;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Manchishi,Stephen;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Sanchez-Tapia,María Jesús;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain.
Pineda,Rafael;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain.
Roa,Juan;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
Argente,Jesús;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain.
Luque,Raúl M.;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
Prevot,Vicent;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France.
Chowen,Julie;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain.
Sharif,Ariane;Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France
Colledge,William H.;Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Tena-Sempere,Manuel;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Institute of Biomedicine, University of Turku, Finland.
Romero,Antonio;Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.

Description

Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin signaling, via, Kiss1r, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a pathway for direct kisspeptin actions in astrocytes that contribute to central reproductive modulation.

License

Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)

References

Funding

BFY2017-83934-P (from Agencia Estatal de Investigación, Spain; co-funded with EU funds from FEDER Program)
PID2019-105564RB-I00 (from Agencia Estatal de Investigación, Spain; co-funded with EU funds from FEDER Program)
PID2020-118660GB-I00 (from Agencia Estatal de Investigación, Spain; co-funded with EU funds from FEDER Program)
Project PIE-14-00005 (Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain)
Projects P12-FQM-01943 and P18-RT-4093 (Junta de Andalucía, Spain)
Project 1254821 (Universidad de Córdoba-FEDER)
BBSRC Project Grant, BB/K003178/1

Keywords

Kisspeptin-signaling
Astrocytes
Reproduction

Resource Type

Dataset