ITD_TWF_Behavior_ECoG_Rat/datacite.yml

authors:
  -
    firstname: Kongyan
    lastname: Li
    affiliation: "Department of Biomedical Sciences and Department of Neuroscience, City\nUniversity of Hong Kong, Hong Kong SAR, China"
  -
    firstname: Ryszard
    lastname: Auksztulewicz
    affiliation: "Department of Biomedical Sciences and Department of Neuroscience, City\nUniversity of Hong Kong, Hong Kong SAR, China"
  -
    firstname: Chloe
    lastname: Chan
    affiliation: "Department of Biomedical Sciences and Department of Neuroscience, City\nUniversity of Hong Kong, Hong Kong SAR, China"
  -
    firstname: Ambika
    lastname: Mishra
    affiliation: "Department of Biomedical Sciences and Department of Neuroscience, City\nUniversity of Hong Kong, Hong Kong SAR, China"
  -
    firstname: Jan
    lastname: Schnupp
    affiliation: "Department of Biomedical Sciences and Department of Neuroscience,\nCity University of Hong Kong, Hong Kong SAR, China; City University of Hong\nKong Shenzhen Research Institute, Shenzhen, China"
title: "The precedence effect in spatial hearing manifests in\ncortical neural population responses"
description: "Background:\nTo localize sound sources accurately in a reverberant environment, human binaural hearing\nstrongly favors analyzing the initial wave front of sounds. Behavioral studies\nof this “precedence effect” have so far largely been confined to human\nsubjects, limiting the scope of complementary physiological approaches.\nSimilarly, physiological studies have mostly looked at neural responses in the\ninferior colliculus, or used modeling of cochlear mechanics in an attempt to identify likely underlying mechanisms. Studies\ncapable of providing a direct comparison of neural coding and behavioral\nmeasures of sound localization under the precedence effect are lacking.\n\n\n\nResults:\nWe adapted a “temporal weighting function” paradigm for use\nin laboratory rats. The animals learned to lateralize click trains in which\neach click in the train had a different interaural time difference. Computing\nthe “perceptual weight” of each click in the train revealed a strong onset\nbias, very similar to that reported for humans. Follow-on electrocorticographic\nrecording experiments revealed that onset weighting of interaural time\ndifferences is a robust feature of the cortical population response, but\ninterestingly it often fails to manifest at individual cortical recording\nsites.\n\n\n\nConclusion:\nWhile previous studies suggested that the precedence effect\nmay be caused by cochlear mechanics or inhibitory circuitry in the brainstem and midbrain, our results indicate that the\nprecedence effect is not fully developed at the level of individual recording\nsites in auditory cortex, but robust and consistent precedence effects are\nobservable at the level of cortical population responses. This indicates that\nthe precedence effect is significantly “higher order” than has hitherto been\nassumed. "
keywords:
  - 'precedence effect'
  - 'onset dominance'
  - rat
  - 'temporal weighting function'
  - 'neural decoding'
  - 'auditory cortex'
license:
  name: 'Creative Commons CC0 1.0 Public Domain Dedication'
  url: 'https://creativecommons.org/publicdomain/zero/1.0/'
funding:
  - 'Hong Kong Medical Research Fund, 06172296'
  - 'Hong Kong General Research Fund, 11101020'
  - 'Shenzhen Science and Innovation Fund, JCYJ20180307124024360'
references:
  -
    id: 'doi: https://doi.org/10.1101/2021.07.21.453295'
    reftype: IsSupplementTo
    citation: 'Li K, Auksztulewicz R, Chan CH, Mishra AP, Schnupp JW. The precedence effect in spatial hearing emerges only late in the auditory pathway. bioRxiv. 2021 Jan 1. '
resourcetype: Dataset
templateversion: 1.2