Gaus_etal_2021_Neuron_numbers_decreased_in_schizophrenia/README.md

Gaus_etal_2021_Neuron_numbers_decreased_in_schizophrenia

Stereological data accompanying the study:

Richard Gaus, Melanie Popal, Helmut Heinsen, Andrea Schmitt, Peter Falkai, Patrick R. Hof, Christoph Schmitz, Alisa Vollhardt (2021) Neuron numbers are decreased in the whole cerebral cortex and in layer V of area 24 in schizophrenia

The repository contains a table (raw_stereology_data.xlsx) with clinical characteristics and raw stereological estimates from the brains of 13 male patients with schizophrenia and 13 age-matched male controls.

Each row in the table represents one individual hemisphere. The table contains the following columns:

Column	Description	Unit
subject	Subject ID
code	Subject code
excl	*
excl_cgm	*
diagnosis	Control: 0, Patient: 1
hemisphere	Left or right hemisphere
age	Age of subject	years
pmi	Post-mortem interval	hours
fix	Fixation time	days
cgm_vol	Volume of whole CGM	cm3
cgm_nn	Total neuron number in whole CGM	x109
cgm_nd	Total neuron density in whole CGM	x106 / cm3
area24_vol	Volume of whole area 24	cm3
area24_nn	Total neuron number in whole area 24	x106
area24_nd	Total neuron density in whole area 24	x106 / cm3
area24layer5_vol	Volume of layer V of area 24	cm3
area24layer5_nn	Total neuron number in layer V of area 24	x106
area24layer5_nd	Total neuron density in layer V of area 24	x106 / cm3
ven_number	VEN number in layer V of area 24	x103
ven_density	VEN density in layer V of area 24	x103 / cm3

*All hemispheres where columns excl / excl_cgm carry the value 1 were excluded from the statistical analysis for all outcome variables / only the CGM-related outcome variables (cgm_vol, cgm_nn, cgm_nd) due to missing sections.

CGM: cortical gray matter; VEN: von Economo neuron

If you plan to use this data for a publication, please inform us about it and don’t forget to cite the source of the data.