Longitudinal (8 wks) T2-weighted MRI and Diffusion Tensor Imaging (DTI) of WT mice with cortical stroke

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README.md

C3a_PT_8wks_T2w_DTI

Longitudinal MRI including T2-weighted (T2w) and Diffusion Tensor Imaging (DTI) of WT mice with cortical stroke lesions induced by photothrombosis (PT) monitored for 8 weeks (8 wks). The mice received either intranasal C3a (complement factor) or PBS treatment from day 7 to day 28 post stroke.

Files:

  • File structure: Study > proc/raw_data > Time point> Group > Subject ID. The physio folder contains the physiological monitoring raw data (breathing, anaesthesia gas, temperature, etc.).
    • Time point (Baseline, post stroke days 7-56)
    • Group (Treatment_C3a/PBS)
  • MRI_raw_data: - contains all raw data in Bruker 2dseq format and the original Bruker folder structure
  • MRI_proc_data: - contains all data processed with the AIDAmri_v1.1 pipeline. Processing steps: define stroke masks, convert Bruker to NIfTI-1 data format, image re-orientation, bias-field correction, brain extraction, region-of-interest segmentation, registration with the Allen Mouse Brain Atlas (CCFv3), structural connectivity analysis.
  • AIDAmri_DTIdata_extract - contains adapted Python scripts from the AIDAmri_v1.1 pipeline to extract diffusion measures (FA, RD, MD, AD) from the DTI data.

Authors:

Markus Aswendt, Olivia Käsgen, Frederique Wieters, Michael Diedenhofen, Dirk Wiedermann

datacite.yml
Title Longitudinal (8 wks) T2-weighted MRI and Diffusion Tensor Imaging (DTI) of WT mice with cortical stroke
Authors Aswendt,Markus;University Hospital Cologne;ORCID:0000-0003-1423-0934
Käsgen,Olivia;University Hospital Cologne
Wieters,Frederique;University Hospital Cologne
Diedenhofen,Michael;Max Planck Institute for Metabolism Research
Wiedermann,Dirk;Max Planck Institute for Metabolism Research
Description Longitudinal MRI including T2-weighted (T2w) and Diffusion Tensor Imaging (DTI) of WT mice with cortical stroke lesions induced by photothrombosis (PT) monitored for 8 weeks (8 wks). The mice received either intranasal C3a (complement factor) or PBS treatment from day 7 to day 28 post stroke.
License CC BY-NC-SA (https://creativecommons.org/licenses/by-nc-sa/4.0/)
References
Funding
Keywords MRI
DTI
Stroke
Recovery
Complement system
Resource Type Dataset