| Title |
Neural effects of dopaminergic compounds revealed by multi-site electrophysiology in mice and interpretable machine-learning |
| Authors |
Kapanaiah,Sampath K.T;Institute for Applied Physiology, Ulm University, Germany
Rosenbrock,Holger;Boehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Germany, Biberach an der Riss, Germany
Hengerer,Bastian;Boehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Germany, Biberach an der Riss, Germany
Kaetzel,Dennis;Institute for Applied Physiology, Ulm University, Germany
|
| Description |
The LFP_RawData folder contains local field potential (LFP) recordings obtained from depth electrodes in the mice brain regions,
including the prelimbic cortex (PrL), mediodorsal thalamus (MD), dorsal hippocampal fissure (dCA1),
dorsal hippocampal CA3 subfield (dCA3), and ventral hippocampal fissure (vHC).
Pharmaco-LFP experiments were conducted approximately every third day in a within-subject design with a latin-square,
randomized drug-assignment across the cohort. Applications included: saline (Sal; vehicle 1),
0.1% TWEEN80/saline (T/Sal; vehicle 2), 1 and 3 mg/kg clozapine (CLZ1 and CLZ3; clozapine dihydrochloride, HB6129, HelloBio, GB),
0.5 mg/kg raclopride (Raclo; S(-)raclopride(+)-tartrate, R121 Sigma, DE), 0.1 mg/kg SCH23390 (SCH; SCH23390 hydrochloride, 0925 Tocris, GB),
and 2 mg/kg amphetamine (Amph; d-amphetamine sulfate, A-5880, Sigma); vehicle 2 was used for raclopride,
all other compounds were applied in saline.
Mice were recorded in Type-III open-field cages (Tecniplast, IT) with fresh saw-dust for a 10 min baseline period,
after which the compound was applied i.p., followed by a further recording for 50 min.
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| License |
CC0 (http://creativecommons.org/publicdomain/zero/1.0)
|
| References |
Kapanaiah, S. K. T., Rosenbrock, H., Hengerer, B., & Kätzel, D. (2024). Neural effects of dopaminergic compounds revealed by multi-site electrophysiology and interpretable machine-learning. Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1412725 [doi: 10.3389/fphar.2024.1412725] (IsSupplementTo)
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| Funding |
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| Keywords |
Neuroscience
Antipsychotics
Neural connectivity
Granger causality
Power spectral density
Electrophysiology
Pharmaco-EEG
Local field potential
|
| Resource Type |
Dataset
|
