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- # Metadata for DOI registration according to DataCite Metadata Schema 4.1.
- # For detailed schema description see https://doi.org/10.5438/0014
- ## Required fields
- # The main researchers involved. Include digital identifier (e.g., ORCID)
- # if possible, including the prefix to indicate its type.
- authors:
- -
- firstname: "Sampath K.T"
- lastname: "Kapanaiah"
- affiliation: "Institute for Applied Physiology, Ulm University, Germany"
- -
- firstname: "Holger"
- lastname: "Rosenbrock"
- affiliation: "Boehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Germany, Biberach an der Riss, Germany"
- -
- firstname: "Bastian"
- lastname: "Hengerer"
- affiliation: "Boehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Germany, Biberach an der Riss, Germany"
- -
- firstname: "Dennis"
- lastname: "Kaetzel"
- affiliation: "Institute for Applied Physiology, Ulm University, Germany"
- # A title to describe the published resource.
- title: "Neural effects of dopaminergic compounds revealed by multi-site electrophysiology in mice and interpretable machine-learning"
- # Additional information about the resource, e.g., a brief abstract.
- description: |
- The LFP_RawData folder contains local field potential (LFP) recordings obtained from depth electrodes in the mice brain regions,
- including the prelimbic cortex (PrL), mediodorsal thalamus (MD), dorsal hippocampal fissure (dCA1),
- dorsal hippocampal CA3 subfield (dCA3), and ventral hippocampal fissure (vHC).
- Pharmaco-LFP experiments were conducted approximately every third day in a within-subject design with a latin-square,
- randomized drug-assignment across the cohort. Applications included: saline (Sal; vehicle 1),
- 0.1% TWEEN80/saline (T/Sal; vehicle 2), 1 and 3 mg/kg clozapine (CLZ1 and CLZ3; clozapine dihydrochloride, HB6129, HelloBio, GB),
- 0.5 mg/kg raclopride (Raclo; S(-)raclopride(+)-tartrate, R121 Sigma, DE), 0.1 mg/kg SCH23390 (SCH; SCH23390 hydrochloride, 0925 Tocris, GB),
- and 2 mg/kg amphetamine (Amph; d-amphetamine sulfate, A-5880, Sigma); vehicle 2 was used for raclopride,
- all other compounds were applied in saline.
- Mice were recorded in Type-III open-field cages (Tecniplast, IT) with fresh saw-dust for a 10 min baseline period,
- after which the compound was applied i.p., followed by a further recording for 50 min.
- # Lit of keywords the resource should be associated with.
- # Give as many keywords as possible, to make the resource findable.
- keywords:
- - Neuroscience
- - Antipsychotics
- - Neural connectivity
- - Granger causality
- - Power spectral density
- - Electrophysiology
- - Pharmaco-EEG
- - Local field potential
- # License information for this resource. Please provide the license name and/or a link to the license.
- # Please add also a corresponding LICENSE file to the repository.
- license:
- name: CC0
- url: 'http://creativecommons.org/publicdomain/zero/1.0'
- # Resource type. Default is Dataset, other possible values are Software, DataPaper, Image, Text.
- references:
- -
- id: "doi: 10.3389/fphar.2024.1412725"
- reftype: "IsSupplementTo"
- citation: "Kapanaiah, S. K. T., Rosenbrock, H., Hengerer, B., & Kätzel, D. (2024). Neural effects of dopaminergic compounds revealed by multi-site electrophysiology and interpretable machine-learning. Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1412725"
- resourcetype: Dataset
- # Do not edit or remove the following line
- templateversion: 1.2
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