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Drangmeister
/
structured_inhibition_spatial_network_model
DOI
10.12751/g-node.abju0s
1
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Rozštěpit 1
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Strom: 29b8619001
Větve Značky
structured_i...
Paul Pfeiffer 29b8619001 refactored simulation of delayed inhibition into a separate class před 4 roky
conmorph fac9d81f25 update imports in old scripts před 4 roky
literature 25246b7e0b first paper on well timed inhibition před 4 roky
models 8b28da9f74 PRC of Hodkin-Huxley with H-current is as desired. Transfer from notebook to script před 4 roky
notebooks 8b28da9f74 PRC of Hodkin-Huxley with H-current is as desired. Transfer from notebook to script před 4 roky
reports 2926565fb1 collections of ideas to tackle feature competition by polar interneurons před 5 roky
scripts 29b8619001 refactored simulation of delayed inhibition into a separate class před 4 roky
simulations 57d9aa725c adapted synaptic strengths před 4 roky
src 179efaba46 spike count extraction, plooting of connectivity profile, allow strings in parameters před 4 roky
tests a1a6f75000 testing for spike train analysis před 4 roky
.gitignore b122729ad8 ignore output data před 4 roky
AUTHORS.rst 3d18bfd015 meta files for scaffolding před 4 roky
CHANGELOG.rst 3d18bfd015 meta files for scaffolding před 4 roky
LICENSE.txt 3d18bfd015 meta files for scaffolding před 4 roky
README.md d7ba11a66b Add README.md před 5 roky
requirements.txt 767703b074 prepared spatial arrangement of the network, used pyscaffold as a scaffolding template před 4 roky
setup.cfg 767703b074 prepared spatial arrangement of the network, used pyscaffold as a scaffolding template před 4 roky
setup.py 767703b074 prepared spatial arrangement of the network, used pyscaffold as a scaffolding template před 4 roky

README.md

Functional aspects of interneuron morphology in the subiculum

Interneurons in the subiculum have a polar axonal cloud instead of a circular as found in other brain regions. Additionally, pyramidal neurons in the subiculum lack recurrent connections, but they connect via recurrent inhibition. Therefore, inhibition plays a major role in this circuitry and we pose the question, which function the extraordinary axon morphology serves in this setting.

Model

  1. Distribute excitatory somata in space.
  2. Distribute inhibitory somata in space.
  3. Choose an axonal shape (polar or circular).
  4. Connect excitatory neurons which are contained the same interneuron axonal cloud.

Analysis

  1. Compare first and second order connectivity

Two neurons directly connected neuron inhibit each other, because they project to the same interneuron (as a circuit motif E<->I<->E). Therefore, second order neighbors are effectively excitatory (via disinhibition). We therefore extracted the distance dependent first and second order connectivity to compare them for polar and circular axonal shapes.