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@@ -1,3 +1,25 @@
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# NATAGING-L01111B
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-Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain
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+**Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain**
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+
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+This folder contains both the raw data and code for data analysis.
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+
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+All raw data related to the publications are collected in the excel file 'All_Data_v2'
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+
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+There are four rar code packages for data analysis.
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+(1) AmiraDataAnalysis.rar
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+ Please unzip the file and load 'RawDataAnl_Vol3_Allcount3_NEW.m' into MATLAB.
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+ This code helps analyze the Amira 3D vasculature shown in Figure 4.
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+
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+(2) DiameterMeasurement.rar
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+ Please unzip the file and load 'VesselDiameter_ByArea_GUI_MAIN.m' into MATLAB.
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+ This code helps analyze vessel diameter change in 4D (xyzt) scanning.
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+
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+(3) IHCAnalysis.rar
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+ Please unzip the file and load 'GliaTrans_POI_GUI_MAIN.m' into MATLAB.
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+ This code helps analyze the alpha-SMA density, pericyte and endothelial cell density from the immunohistochemical images in Figure 1.
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+
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+(4) MathModel.rar
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+ Please unzip the file and load 'amirachangsianal.py'into Python.
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+ This code makes math model of existing vasculatures to estimate the blood pressure and flow at each vessel segment.
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