xiaxiaxu/Developmental_ephys_LEC-HP-PFC: This repository contains the ephys data related to the article " Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice ". We provide optogenetic in vivo recordings of LEC, HP, PFC in non-anesthetized and urethane-anesthetized mice of control and GE mice in the right hemisphere.

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Xiaxia 372c1a1e17 上传文件至 'LEC_terminalChR_HP'		3 vuotta sitten
2021-05-10_19-08-50	f38198ea7a 上传文件至 ''	3 vuotta sitten
Behavior	9973a2dacd 上传文件至 'Behavior'	3 vuotta sitten
Histology	70cab8400d 上传文件至 'Histology'	3 vuotta sitten
LEC_terminalChR_HP	372c1a1e17 上传文件至 'LEC_terminalChR_HP'	3 vuotta sitten
SUA	ce75a6e993 上传文件至 'SUA'	3 vuotta sitten
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LICENSE	a0b7312c12 上传文件至 ''	3 vuotta sitten
README.md	4c2ce12495 Initial commit	3 vuotta sitten
datacite.yml	223f29d672 更新 'datacite.yml'	3 vuotta sitten

Xiaxia 372c1a1e17 上传文件至 'LEC_terminalChR_HP'

3 vuotta sitten

2021-05-10_19-08-50

f38198ea7a 上传文件至 ''

3 vuotta sitten

Behavior

9973a2dacd 上传文件至 'Behavior'

3 vuotta sitten

Histology

70cab8400d 上传文件至 'Histology'

3 vuotta sitten

LEC_terminalChR_HP

372c1a1e17 上传文件至 'LEC_terminalChR_HP'

3 vuotta sitten

SUA

ce75a6e993 上传文件至 'SUA'

3 vuotta sitten

eOPN3

456a57379b 上传文件至 'eOPN3'

3 vuotta sitten

LICENSE

a0b7312c12 上传文件至 ''

3 vuotta sitten

README.md

4c2ce12495 Initial commit

3 vuotta sitten

datacite.yml

223f29d672 更新 'datacite.yml'

3 vuotta sitten

Developmental_ephys_LEC-HP-PFC

This repository contains the ephys data related to the article " Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice ". We provide optogenetic in vivo recordings of LEC, HP, PFC in non-anesthetized and urethane-anesthetized mice of control and GE mice in the right hemisphere.

datacite.yml
Title	Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice
Authors	Xu,Xiaxia;University Medical Center Hamburg-Eppendorf Song,Lingzhen;University Medical Center Hamburg-Eppendorf Kringel,Rebecca;University Medical Center Hamburg-Eppendorf Hanganu-Opatz,Ileana L;University Medical Center Hamburg-Eppendorf
Description	The prefrontal-hippocampal dysfunction that underlies cognitive deficits in mental disorders emerges during early development. The lateral entorhinal cortex (LEC) is tightly interconnected with both prefrontal cortex (PFC) and hippocampus (HP), yet its contribution to the early dysfunction is fully unknown. Here we show that mice that mimic the dual genetic (G) -environmental (E) etiology (GE mice) of psychiatric risk have poor LEC-dependent recognition memory at pre-juvenile age and abnormal communication within LEC-HP-PFC networks throughout development. These functional and behavioral deficits relate to sparser projections from LEC to CA1 and decreased efficiency of axonal terminals to activate the hippocampal circuits in neonatal GE mice. In contrast, the direct entorhinal drive to PFC is not affected, yet the PFC is indirectly compromised, as target of the under-activated HP. Thus, the entorhinal-hippocampal circuit is already impaired from neonatal age on in GE mice.
License	Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
References	Xiaxia Xu, Lingzhen Song, Rebecca Kringel et al. Developmental decrease of entorhinal gate disrupts prefrontal-hippocampal communication in immune-challenged DISC1 knockdown mice, 10 March 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-290304/v1] [https://doi.org/10.21203/RS.3.RS-290304/V1] (IsSupplementTo)
Funding	DFG, SFB 936 B5 and Ha4466/11-1 to I.L.H.-O EU, ERC-2015-CoG 681577 to I.L.H.-O.
Keywords	Neuroscience LEC DISC1
Resource Type	Dataset

datacite.yml

Title

Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice

Authors

Xu,Xiaxia;University Medical Center Hamburg-Eppendorf
Song,Lingzhen;University Medical Center Hamburg-Eppendorf
Kringel,Rebecca;University Medical Center Hamburg-Eppendorf
Hanganu-Opatz,Ileana L;University Medical Center Hamburg-Eppendorf

Description

The prefrontal-hippocampal dysfunction that underlies cognitive deficits in mental disorders emerges during early development. The lateral entorhinal cortex (LEC) is tightly interconnected with both prefrontal cortex (PFC) and hippocampus (HP), yet its contribution to the early dysfunction is fully unknown. Here we show that mice that mimic the dual genetic (G) -environmental (E) etiology (GE mice) of psychiatric risk have poor LEC-dependent recognition memory at pre-juvenile age and abnormal communication within LEC-HP-PFC networks throughout development. These functional and behavioral deficits relate to sparser projections from LEC to CA1 and decreased efficiency of axonal terminals to activate the hippocampal circuits in neonatal GE mice. In contrast, the direct entorhinal drive to PFC is not affected, yet the PFC is indirectly compromised, as target of the under-activated HP. Thus, the entorhinal-hippocampal circuit is already impaired from neonatal age on in GE mice.

License

Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)

References

Xiaxia Xu, Lingzhen Song, Rebecca Kringel et al. Developmental decrease of entorhinal gate disrupts prefrontal-hippocampal communication in immune-challenged DISC1 knockdown mice, 10 March 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-290304/v1] [https://doi.org/10.21203/RS.3.RS-290304/V1] (IsSupplementTo)

Funding

DFG, SFB 936 B5 and Ha4466/11-1 to I.L.H.-O
EU, ERC-2015-CoG 681577 to I.L.H.-O.

Keywords

Neuroscience
LEC
DISC1

Resource Type

Dataset