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@@ -2,19 +2,19 @@ authors:
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firstname: Xiaxia
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lastname: Xu
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- affiliation: "University Medical Center\nHamburg-Eppendorf"
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+ affiliation: University Medical Center\nHamburg-Eppendorf
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firstname: Lingzhen
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lastname: Song
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- affiliation: "University Medical Center\nHamburg-Eppendorf"
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+ affiliation: University Medical Center\nHamburg-Eppendorf
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firstname: Rebecca
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lastname: Kringel
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- affiliation: "University Medical Center\nHamburg-Eppendorf"
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+ affiliation: University Medical Center\nHamburg-Eppendorf
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- firstname: 'Ileana L '
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+ firstname: Ileana L
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lastname: Hanganu-Opatz
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- affiliation: "University Medical Center\nHamburg-Eppendorf"
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+ affiliation: University Medical Center\nHamburg-Eppendorf
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title: 'Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice'
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description: 'The prefrontal-hippocampal dysfunction that underlies cognitive deficits in mental disorders emerges during early development. The lateral entorhinal cortex (LEC) is tightly interconnected with both prefrontal cortex (PFC) and hippocampus (HP), yet its contribution to the early dysfunction is fully unknown. Here we show that mice that mimic the dual genetic (G) -environmental (E) etiology (GE mice) of psychiatric risk have poor LEC-dependent recognition memory at pre-juvenile age and abnormal communication within LEC-HP-PFC networks throughout development. These functional and behavioral deficits relate to sparser projections from LEC to CA1 and decreased efficiency of axonal terminals to activate the hippocampal circuits in neonatal GE mice. In contrast, the direct entorhinal drive to PFC is not affected, yet the PFC is indirectly compromised, as target of the under-activated HP. Thus, the entorhinal-hippocampal circuit is already impaired from neonatal age on in GE mice.'
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keywords:
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@@ -23,14 +23,14 @@ keywords:
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- DISC1
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license:
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name: CC-BY
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-url: 'http://creativecommons.org/licenses/by/4.0/'
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+url: http://creativecommons.org/licenses/by/4.0/
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funding:
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- - 'SFB, 936 B5'
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- - 'ERC,ERC-2015-CoG 681577 '
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+ - SFB, 936 B5
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+ - ERC,ERC-2015-CoG 681577
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references:
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-
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- id: 'https://doi.org/10.21203/RS.3.RS-290304/V1'
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+ id: https://doi.org/10.21203/RS.3.RS-290304/V1
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reftype: IsSupplementTo
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- citation: 'Xiaxia Xu, Lingzhen Song, Rebecca Kringel, Ileana Hanganu-Opatz. Developmental decrease of entorhinal gate disrupts prefrontal-hippocampal communication in immune-challenged DISC1 knockdown mice. '
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+ citation: Xiaxia Xu, Lingzhen Song, Rebecca Kringel, Ileana Hanganu-Opatz. Developmental decrease of entorhinal gate disrupts prefrontal-hippocampal communication in immune-challenged DISC1 knockdown mice.
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resourcetype: Dataset
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templateversion: 1.2
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