CITATION.tex 9.7 KB

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  54. \date{}
  55. \begin{document}
  56. Results included in this manuscript come from preprocessing performed
  57. using \emph{fMRIPrep} 20.1.1+79.g1a72777b (\citet{fmriprep1};
  58. \citet{fmriprep2}; RRID:SCR\_016216), which is based on \emph{Nipype}
  59. 1.5.0 (\citet{nipype1}; \citet{nipype2}; RRID:SCR\_002502).
  60. \begin{description}
  61. \item[Anatomical data preprocessing]
  62. A total of 2 T1-weighted (T1w) images were found within the input BIDS
  63. dataset. All of them were corrected for intensity non-uniformity (INU)
  64. with \texttt{N4BiasFieldCorrection} \citep{n4}, distributed with ANTs
  65. 2.2.0 \citep[RRID:SCR\_004757]{ants}. The T1w-reference was then
  66. skull-stripped with a \emph{Nipype} implementation of the
  67. \texttt{antsBrainExtraction.sh} workflow (from ANTs), using OASIS30ANTs
  68. as target template. Brain tissue segmentation of cerebrospinal fluid
  69. (CSF), white-matter (WM) and gray-matter (GM) was performed on the
  70. brain-extracted T1w using \texttt{fast} \citep[FSL 5.0.9,
  71. RRID:SCR\_002823,][]{fsl_fast}. A T1w-reference map was computed after
  72. registration of 2 T1w images (after INU-correction) using
  73. \texttt{mri\_robust\_template} \citep[FreeSurfer 6.0.1,][]{fs_template}.
  74. Brain surfaces were reconstructed using \texttt{recon-all}
  75. \citep[FreeSurfer 6.0.1, RRID:SCR\_001847,][]{fs_reconall}, and the
  76. brain mask estimated previously was refined with a custom variation of
  77. the method to reconcile ANTs-derived and FreeSurfer-derived
  78. segmentations of the cortical gray-matter of Mindboggle
  79. \citep[RRID:SCR\_002438,][]{mindboggle}. Volume-based spatial
  80. normalization to two standard spaces (MNI152NLin2009cAsym,
  81. MNI152NLin6Asym) was performed through nonlinear registration with
  82. \texttt{antsRegistration} (ANTs 2.2.0), using brain-extracted versions
  83. of both T1w reference and the T1w template. The following templates were
  84. selected for spatial normalization: \emph{ICBM 152 Nonlinear
  85. Asymmetrical template version 2009c} {[}\citet{mni152nlin2009casym},
  86. RRID:SCR\_008796; TemplateFlow ID: MNI152NLin2009cAsym{]}, \emph{FSL's
  87. MNI ICBM 152 non-linear 6th Generation Asymmetric Average Brain
  88. Stereotaxic Registration Model} {[}\citet{mni152nlin6asym},
  89. RRID:SCR\_002823; TemplateFlow ID: MNI152NLin6Asym{]},
  90. \item[Functional data preprocessing]
  91. For each of the 10 BOLD runs found per subject (across all tasks and
  92. sessions), the following preprocessing was performed. First, a reference
  93. volume and its skull-stripped version were generated using a custom
  94. methodology of \emph{fMRIPrep}. Susceptibility distortion correction
  95. (SDC) was omitted. The BOLD reference was then co-registered to the T1w
  96. reference using \texttt{bbregister} (FreeSurfer) which implements
  97. boundary-based registration \citep{bbr}. Co-registration was configured
  98. with six degrees of freedom. Head-motion parameters with respect to the
  99. BOLD reference (transformation matrices, and six corresponding rotation
  100. and translation parameters) are estimated before any spatiotemporal
  101. filtering using \texttt{mcflirt} \citep[FSL 5.0.9,][]{mcflirt}. BOLD
  102. runs were slice-time corrected using \texttt{3dTshift} from AFNI
  103. 20160207 \citep[RRID:SCR\_005927]{afni}. The BOLD time-series were
  104. resampled onto the following surfaces (FreeSurfer reconstruction
  105. nomenclature): \emph{fsaverage}. The BOLD time-series (including
  106. slice-timing correction when applied) were resampled onto their
  107. original, native space by applying the transforms to correct for
  108. head-motion. These resampled BOLD time-series will be referred to as
  109. \emph{preprocessed BOLD in original space}, or just \emph{preprocessed
  110. BOLD}. \emph{Grayordinates} files \citep{hcppipelines} containing 91k
  111. samples were also generated using the highest-resolution
  112. \texttt{fsaverage} as intermediate standardized surface space. Automatic
  113. removal of motion artifacts using independent component analysis
  114. \citep[ICA-AROMA,][]{aroma} was performed on the \emph{preprocessed BOLD
  115. on MNI space} time-series after removal of non-steady state volumes and
  116. spatial smoothing with an isotropic, Gaussian kernel of 6mm FWHM
  117. (full-width half-maximum). Corresponding ``non-aggresively'' denoised
  118. runs were produced after such smoothing. Additionally, the
  119. ``aggressive'' noise-regressors were collected and placed in the
  120. corresponding confounds file. Several confounding time-series were
  121. calculated based on the \emph{preprocessed BOLD}: framewise displacement
  122. (FD), DVARS and three region-wise global signals. FD was computed using
  123. two formulations following Power (absolute sum of relative motions,
  124. \citet{power_fd_dvars}) and Jenkinson (relative root mean square
  125. displacement between affines, \citet{mcflirt}). FD and DVARS are
  126. calculated for each functional run, both using their implementations in
  127. \emph{Nipype} \citep[following the definitions by][]{power_fd_dvars}.
  128. The three global signals are extracted within the CSF, the WM, and the
  129. whole-brain masks. Additionally, a set of physiological regressors were
  130. extracted to allow for component-based noise correction
  131. \citep[\emph{CompCor},][]{compcor}. Principal components are estimated
  132. after high-pass filtering the \emph{preprocessed BOLD} time-series
  133. (using a discrete cosine filter with 128s cut-off) for the two
  134. \emph{CompCor} variants: temporal (tCompCor) and anatomical (aCompCor).
  135. tCompCor components are then calculated from the top 2\% variable voxels
  136. within the brain mask. For aCompCor, three probabilistic masks (CSF, WM
  137. and combined CSF+WM) are generated in anatomical space. The
  138. implementation differs from that of Behzadi et al.~in that instead of
  139. eroding the masks by 2 pixels on BOLD space, the aCompCor masks are
  140. subtracted a mask of pixels that likely contain a volume fraction of GM.
  141. This mask is obtained by dilating a GM mask extracted from the
  142. FreeSurfer's \emph{aseg} segmentation, and it ensures components are not
  143. extracted from voxels containing a minimal fraction of GM. Finally,
  144. these masks are resampled into BOLD space and binarized by thresholding
  145. at 0.99 (as in the original implementation). Components are also
  146. calculated separately within the WM and CSF masks. For each CompCor
  147. decomposition, the \emph{k} components with the largest singular values
  148. are retained, such that the retained components' time series are
  149. sufficient to explain 50 percent of variance across the nuisance mask
  150. (CSF, WM, combined, or temporal). The remaining components are dropped
  151. from consideration. The head-motion estimates calculated in the
  152. correction step were also placed within the corresponding confounds
  153. file. The confound time series derived from head motion estimates and
  154. global signals were expanded with the inclusion of temporal derivatives
  155. and quadratic terms for each \citep{confounds_satterthwaite_2013}.
  156. Frames that exceeded a threshold of 0.5 mm FD or 1.5 standardised DVARS
  157. were annotated as motion outliers. All resamplings can be performed with
  158. \emph{a single interpolation step} by composing all the pertinent
  159. transformations (i.e.~head-motion transform matrices, susceptibility
  160. distortion correction when available, and co-registrations to anatomical
  161. and output spaces). Gridded (volumetric) resamplings were performed
  162. using \texttt{antsApplyTransforms} (ANTs), configured with Lanczos
  163. interpolation to minimize the smoothing effects of other kernels
  164. \citep{lanczos}. Non-gridded (surface) resamplings were performed using
  165. \texttt{mri\_vol2surf} (FreeSurfer).
  166. \end{description}
  167. Many internal operations of \emph{fMRIPrep} use \emph{Nilearn} 0.6.2
  168. \citep[RRID:SCR\_001362]{nilearn}, mostly within the functional
  169. processing workflow. For more details of the pipeline, see
  170. \href{https://fmriprep.readthedocs.io/en/latest/workflows.html}{the
  171. section corresponding to workflows in \emph{fMRIPrep}'s documentation}.
  172. \hypertarget{copyright-waiver}{%
  173. \subsubsection{Copyright Waiver}\label{copyright-waiver}}
  174. The above boilerplate text was automatically generated by fMRIPrep with
  175. the express intention that users should copy and paste this text into
  176. their manuscripts \emph{unchanged}. It is released under the
  177. \href{https://creativecommons.org/publicdomain/zero/1.0/}{CC0} license.
  178. \hypertarget{references}{%
  179. \subsubsection{References}\label{references}}
  180. \bibliography{/usr/local/miniconda/lib/python3.7/site-packages/fmriprep/data/boilerplate.bib}
  181. \end{document}