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@@ -6,6 +6,8 @@ Files in '24 hours' are recordings 24 hours after LSD or SAL injections.
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Files in 'base' are baseline recordings during IL (mPFC) stimulation.
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Files in 'postLSD' are recordings during stimulation after LSD injections.
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+Code for analysis can be found on GitHub (https://github.com/lucasdwi/code/blob/master/notes/lsdPaperNotes.m)
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Background: Psychedelics have resurged in neuroscience and psychiatry with promising success in psychedelic-assisted therapy for the treatment of anxiety, depression, and addiction. At the cellular level, psychedelics elicit neuroplastic processes 24 hours after administration, priming neural circuits for change. The acute effects of psychedelics are well characterized with functional imaging and neural oscillations showing an increase in the entropy of spontaneous cortical activity.
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Hypotheses: We hypothesized that cortical-striatal oscillations recorded in rats would confirm the effects of psychedelics. We also hypothesized that brain stimulation delivered 24 hours after LSD administration would lead to different effects than brain stimulation alone.
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Methods: We recorded local field potential (LFP) oscillations from rats following lysergic acid diethylamide (LSD) or saline administration and determined if exposure to these treatments altered the effect of a targeted intervention (brain stimulation) 24 hours later.
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