CITATION.tex 7.4 KB

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  54. \date{}
  55. \begin{document}
  56. Results included in this manuscript come from preprocessing performed
  57. using \emph{fMRIPprep} 1.2.6-1 (\citet{fmriprep1}; \citet{fmriprep2};
  58. RRID:SCR\_016216), which is based on \emph{Nipype} 1.1.7
  59. (\citet{nipype1}; \citet{nipype2}; RRID:SCR\_002502).
  60. \begin{description}
  61. \item[Anatomical data preprocessing]
  62. The T1-weighted (T1w) image was corrected for intensity non-uniformity
  63. (INU) using \texttt{N4BiasFieldCorrection} \citep[ANTs 2.2.0]{n4}, and
  64. used as T1w-reference throughout the workflow. The T1w-reference was
  65. then skull-stripped using \texttt{antsBrainExtraction.sh} (ANTs 2.2.0),
  66. using OASIS as target template. Spatial normalization to the ICBM 152
  67. Nonlinear Asymmetrical template version 2009c
  68. \citep[RRID:SCR\_008796]{mni} was performed through nonlinear
  69. registration with \texttt{antsRegistration} \citep[ANTs 2.2.0,
  70. RRID:SCR\_004757,][]{ants}, using brain-extracted versions of both T1w
  71. volume and template. Brain tissue segmentation of cerebrospinal fluid
  72. (CSF), white-matter (WM) and gray-matter (GM) was performed on the
  73. brain-extracted T1w using \texttt{fast} \citep[FSL 5.0.9,
  74. RRID:SCR\_002823,][]{fsl_fast}.
  75. \item[Functional data preprocessing]
  76. For each of the 1 BOLD runs found per subject (across all tasks and
  77. sessions), the following preprocessing was performed. First, a reference
  78. volume and its skull-stripped version were generated using a custom
  79. methodology of \emph{fMRIPrep}. A deformation field to correct for
  80. susceptibility distortions was estimated based on \emph{fMRIPrep}'s
  81. \emph{fieldmap-less} approach. The deformation field is that resulting
  82. from co-registering the BOLD reference to the same-subject T1w-reference
  83. with its intensity inverted \citep{fieldmapless1, fieldmapless2}.
  84. Registration is performed with \texttt{antsRegistration} (ANTs 2.2.0),
  85. and the process regularized by constraining deformation to be nonzero
  86. only along the phase-encoding direction, and modulated with an average
  87. fieldmap template \citep{fieldmapless3}. Based on the estimated
  88. susceptibility distortion, an unwarped BOLD reference was calculated for
  89. a more accurate co-registration with the anatomical reference. The BOLD
  90. reference was then co-registered to the T1w reference using
  91. \texttt{flirt} \citep[FSL 5.0.9,][]{flirt} with the boundary-based
  92. registration \citep{bbr} cost-function. Co-registration was configured
  93. with nine degrees of freedom to account for distortions remaining in the
  94. BOLD reference. Head-motion parameters with respect to the BOLD
  95. reference (transformation matrices, and six corresponding rotation and
  96. translation parameters) are estimated before any spatiotemporal
  97. filtering using \texttt{mcflirt} \citep[FSL 5.0.9,][]{mcflirt}. The BOLD
  98. time-series (including slice-timing correction when applied) were
  99. resampled onto their original, native space by applying a single,
  100. composite transform to correct for head-motion and susceptibility
  101. distortions. These resampled BOLD time-series will be referred to as
  102. \emph{preprocessed BOLD in original space}, or just \emph{preprocessed
  103. BOLD}. The BOLD time-series were resampled to MNI152NLin2009cAsym
  104. standard space, generating a \emph{preprocessed BOLD run in
  105. MNI152NLin2009cAsym space}. First, a reference volume and its
  106. skull-stripped version were generated using a custom methodology of
  107. \emph{fMRIPrep}. Several confounding time-series were calculated based
  108. on the \emph{preprocessed BOLD}: framewise displacement (FD), DVARS and
  109. three region-wise global signals. FD and DVARS are calculated for each
  110. functional run, both using their implementations in \emph{Nipype}
  111. \citep[following the definitions by][]{power_fd_dvars}. The three global
  112. signals are extracted within the CSF, the WM, and the whole-brain masks.
  113. Additionally, a set of physiological regressors were extracted to allow
  114. for component-based noise correction \citep[\emph{CompCor},][]{compcor}.
  115. Principal components are estimated after high-pass filtering the
  116. \emph{preprocessed BOLD} time-series (using a discrete cosine filter
  117. with 128s cut-off) for the two \emph{CompCor} variants: temporal
  118. (tCompCor) and anatomical (aCompCor). Six tCompCor components are then
  119. calculated from the top 5\% variable voxels within a mask covering the
  120. subcortical regions. This subcortical mask is obtained by heavily
  121. eroding the brain mask, which ensures it does not include cortical GM
  122. regions. For aCompCor, six components are calculated within the
  123. intersection of the aforementioned mask and the union of CSF and WM
  124. masks calculated in T1w space, after their projection to the native
  125. space of each functional run (using the inverse BOLD-to-T1w
  126. transformation). The head-motion estimates calculated in the correction
  127. step were also placed within the corresponding confounds file. All
  128. resamplings can be performed with \emph{a single interpolation step} by
  129. composing all the pertinent transformations (i.e.~head-motion transform
  130. matrices, susceptibility distortion correction when available, and
  131. co-registrations to anatomical and template spaces). Gridded
  132. (volumetric) resamplings were performed using
  133. \texttt{antsApplyTransforms} (ANTs), configured with Lanczos
  134. interpolation to minimize the smoothing effects of other kernels
  135. \citep{lanczos}. Non-gridded (surface) resamplings were performed using
  136. \texttt{mri\_vol2surf} (FreeSurfer).
  137. \end{description}
  138. Many internal operations of \emph{fMRIPrep} use \emph{Nilearn} 0.5.0
  139. \citep[RRID:SCR\_001362]{nilearn}, mostly within the functional
  140. processing workflow. For more details of the pipeline, see
  141. \href{https://fmriprep.readthedocs.io/en/latest/workflows.html}{the
  142. section corresponding to workflows in \emph{fMRIPrep}'s documentation}.
  143. \hypertarget{references}{%
  144. \subsubsection{References}\label{references}}
  145. \bibliography{/usr/local/miniconda/lib/python3.7/site-packages/fmriprep/data/boilerplate.bib}
  146. \end{document}