MALPEM_ADNI_data

Readme

This repository contains data resources accompanying the article:

C. Ledig, A. Schuh, R. Guerrero, R. Heckemann, D. Rueckert "Structural brain imaging in Alzheimer's disease and mild cognitive impairment: biomarker analysis and shared morphometry database", Scientific Reports, 2018.

This work was done in the BioMedIA group at Imperial College London, UK.

Citation

Please cite as:

@article{Ledig2018,
  title={Structural brain imaging in Alzheimer's disease and mild cognitive impairment: biomarker analysis and shared morphometry database},
  author={Ledig, Christian and Schuh, Andreas and Guerrero, Ricardo and Heckemann, Rolf and Rueckert, Daniel},
  journal={Scientific Reports},
  year={2018},
  publisher={Nature Publishing Group}
}

File Description

Processed Images

• List of all 5074 images (includes baseline and follow up images) [ADNI_MALPEM_all_5074.csv]
• List of 1069 baseline images used for analysis [ADNI_MALPEM_baseline_1069.csv]
• List of 802 m12 follow up images used for analysis [ADNI_MALPEM_m12_802.csv]
• List of 532 m24 follow up images used for analysis [ADNI_MALPEM_m24_532.csv]

Features

• All extracted cross-sectional (structural volumes) and longitudinal (volume change rate) features and selected clinical information (e.g. disease labels). Note: Not all of those features have been used in the manuscript. Please, refer to the paper for details. [features_CrossSect-5074_LongBLM12-802_LongBLM24-532.zip]

Segmentations / Brain masks

• 5074 cross-sectional structural segmentations in 138 distinct anatomical regions (calculated with MALPEM) [MALPEM_cross-sectional_seg138_5074.zip]
• 5074 binary brain masks (calculated with pincram). Masks have been quality checked (baseline: visual, followup: automatic) [pincram_bin_brain_masks_5074.zip]
• Lookup table for all segmented 138 brain structures [lut.csv]
  

License

The data in this repository is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International Public License. See the accompanying license file for details. The license does not allow usage of this data for commercial applications. This restriction is derived from the license of the Neuromorphometrics atlases (CC BY-NC).

Methodology

Multi-Atlas Label Propagation with Expecation-Maximisation based refinement (MALPEM) including pincram brain extraction is publicly available on github: [MALPEM]

We are working on releasing the actual source code of MALPEM within [MIRTK]

References

Framework and cross-sectional segmentation [paper]

C. Ledig, R. A. Heckemann, A. Hammers, J. C. Lopez, V. F. J. Newcombe, A. Makropoulos, J. Loetjoenen, D. Menon and D. Rueckert, "Robust whole-brain segmentation: Application to traumatic brain injury", Medical Image Analysis, 21(1), pp. 40-58, 2015.

Longitudinal segmentation [paper]

C. Ledig, W. Shi, A. Makropoulos, J. Koikkalainen, R. A. Heckemann, A. Hammers, J. Lötjönen, and D. Rueckert, "Consistent and robust 4D whole-brain segmentation: application to traumatic brain injury", Proceedings of ISBI 2014, pp. 673-676, 2014

Brain extraction [paper]

R. Heckemann, C. Ledig, K. R. Gray, P. Aljabar, D. Rueckert, J. V. Hajnal, and A. Hammers, "Brain extraction using label propagation and group agreement: pincram", PLoS ONE, 10(7), pp. e0129211, 2015.