Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer’s Disease and Related Dementias

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ADRDSulfides

Neuroimaging dataset for "Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer’s Disease and Related Dementias". Contains T1, FLAIR, and DTI images for each subject in BIDS format.

datacite.yml
Title	Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer's Disease and Related Dementias
Authors	Reekes,Tyler H.;LSUHS;0000-0003-4131-1094 Ledbetter,Christina R.;LSUHS;0000-0001-8581-6065 Pardue,Sibile;LSUHS;0000-0002-5133-7901 Alexander,J. Steven;LSUHS;0000-0001-6975-3711 Stokes,Karen Y.;LSUHS;0000-0002-7612-3467 Bhuiyan,Mohammad Alfrad Nobel;LSUHS;0000-0002-6011-2624 Patterson,James C.;LSUHS;0000-0001-5709-2557 Lofton,Katelyn T.;LSUHS;0000-0001-9620-1162 Kevil,Christopher G.;LSUHS;0000-0003-0863-7260 Disbrow,Elizabeth A.;LSUHS;0000-0002-2133-3221
Description	Emerging evidence indicates that vascular stress is an important contributor to the pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide (H2S) and its metabolites (acid-labile (e.g., iron-sulfur clusters) and bound (e.g., per-, poly-sulfides) have been shown to regulate both vascular and neuronal homeostasis. We recently reported that elevated plasma sulfides were associated with cognitive dysfunction and microvascular disease in ADRD; here we extend our previous work to show associations between elevated sulfides and magnetic resonance-based metrics of brain atrophy and white matter integrity. Elevated bound sulfides were associated with decreased measures of gray matter volume, while increased acid labile sulfides were associated with measures of decreased white matter integrity and increased ventricular volume. These findings are consistent with a ‘toxic’ sulfide model of ADRD. Our results are consistent with a compensatory sulfide response to oxidative stress.
License	Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
References	Citation1 [doi::tba] (IsDescribedBy)
Funding	NIH, 3P2012130701A1S1 NIH, HL149264-01A1
Keywords	Alzheimer's Disease hydrogen sulfide dementia cortical thickness white matter integrity neuroimaging
Resource Type	Dataset

README.md

ADRDSulfides