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@@ -24,13 +24,7 @@ authors:
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title: "fmri raw data"
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# Additional information about the resource, e.g., a brief abstract.
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-description: Objective: to assess patterns and predictors of representation of motor and language functions and of postoperative language cortex reorganization in patients with lesional epilepsy.
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-Methods: This is a prospective study. Forty patients underwent a preoperative structural and functional 3T brain MRI during sensorimotor and language tasks, depending on the localization of the epileptogenic lesion. Twenty patients also underwent postoperative language fMRI. DTI data were acquired in 24 patients. We hypothesized a causal model to test whether clinical, EEG and surgical variables would influence fMRI results and the latter have an impact on cognitive outcome. For the postoperative study, we analyzed associations between changes of Laterality Index (LI) and several clinical variables.
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-Results: No distortion of the representation of sensorimotor homunculus was observed in 14/16 patients. The two remaining patients exhibited a post-infectious scar extending to the front-parietal region. Diffuse interictal EEG abnormalities were associated with more atypical language representation on fMRI (p = 0.014), which in turn correlated with attention problems (p=0.0358) and low IQ/GDQ scores (p = 0.0136). Normal postoperative EEG (p=0.003) and seizure freedom (p=0.015) were associated with shifting towards LI increase, which in turn correlated with improved or stable fluency. Concerning DTI, neither preoperative asymmetry nor postoperative changes in the arcuate fasciculus LIs were observed.
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-Interpretation: The observation that diffuse abnormalities??? (non è chiaro) EEG may favor atypical language lateralization and worse cognitive outcome, which are potentially reversible after successful epilepsy surgery, should prompt clinicians to consider early surgical treatment in patients exhibiting these electroclinical features. |
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- Example description
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- that can contain linebreaks
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- but has to maintain indentation.
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+description: "Patterns and predictors of motor and language representation in children with lesional epilepsy (fmri raw data pre and post)"
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