Title |
Survival, nrf2, internal concentration, and external concentration timeseries of zebrafish embryos exposed to Diuron, Diclofenac or Naproxen used in TKTD modelling |
Authors |
Kodritsch,Bernhard;Helmholtz-Centre for Environmental Research GmbH---UFZ, Permoserstr. 15, 04318 Leipzig, Germany
Schunck,Florian;Osnabrück University, Barbarastr. 12, 49076 Osnabrück, Germany;ORCID:0000-0001-7245-953X
Krauss,Martin;Helmholtz-Centre for Environmental Research GmbH---UFZ, Permoserstr. 15, 04318 Leipzig, Germany;ORCID:0000-0002-0362-4244
Focks,Andreas;Osnabrück University, Barbarastr. 12, 49076 Osnabrück, Germany;ORCID:0000-0002-9031-0808
Busch,Wibke;Helmholtz-Centre for Environmental Research GmbH---UFZ, Permoserstr. 15, 04318 Leipzig, Germany;ORCID:0000-0002-5497-6266
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Description |
The dataset contains a number of experiments generated during 2015--2022 at the Helmholtz Centre for Environmental Research---UFZ in Leipzig. The data describe observations of different endpoints measured in zebrafish embryos (ZFE), exposed to the chemicals Diuron, Diclofenac and Naproxen (separately). The observed endpoints were external concentrations, internal body residues in the ZFE, gene expression of *nrf2* (a transcription factor that handles the stress response), and survival. The recommended way to work with this dataset is with the companion code, available under https://github.com/flo-schu/tktd_nrf2_zfe/.
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License |
Creative Commons Attribution-ShareAlike 4.0 (https://creativecommons.org/licenses/by-sa/4.0/deed.en)
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References |
Schunck F, Kodritsch B, Busch W, Kraus M, Focks A (2024) [doi:tba] (IsSupplementTo)
Analysis of scattered timeseries data from multiple experiments with pymob. Schunck 2024. Github [url:https://github.com/flo-schu/tktd_nrf2_zfe] (IsReferencedBy)
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Funding |
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Keywords |
TKTD modelling
zebrafish
nrf2
internal concentration
gene expression
timeseries
survival
modelling
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Resource Type |
Dataset
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