Behaviour and EEG recorded during the touchscreen Visual Disrimination task performance in rats
Diana Kostyalik
769b2859d0
Frissítés "README.md"
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há 2 anos atrás | |
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| Behavioural data | há 2 anos atrás | |
| MK-801_EEG | há 2 anos atrás | |
| Scopolamine_EEG | há 2 anos atrás | |
| LICENSE | há 2 anos atrás | |
| README.md | há 2 anos atrás | |
| datacite.yml | há 2 anos atrás |
Behaviour and EEG recorded during the touchscreen Visual Disrimination task performance in rats
.smr files contain raw EEG data of rats' epidural EEG recordings Subjects were marked with S001-S012
Electrode channel numbers
Bad Channels in each rat: 5, 6 (no electrode was implanted)
triggers: samplingRate = 10000;
triggerS: channel 12- correct touch channel 13- incorrect touch channel 14- image displayed channel 15- tray entry
| datacite.yml | |
|---|---|
| Title | Response-related sensorimotor rhythms under scopolamine and MK-801 exposures in the touchscreen Visual Discrimination test in rats |
| Authors |
Kostyalik,Diana;Cognitive Pharmacology Laboratory, Department of Pharmacology and Drug Safety, Gedeon Richter Plc;ORCID:0000-0003-3552-4528
Kelemen,Kristóf;Cognitive Pharmacology Laboratory, Department of Pharmacology and Drug Safety, Gedeon Richter Plc;ORCID:0000-0001-7378-0843 Lendvai,Balázs ;Department of Pharmacology and Drug Safety,Gedeon Richter Plc;ORCID:0000-0001-9289-4715 Hernádi,István;Department of Pharmacology and Drug Safety,Gedeon Richter Plc;ORCID:0000-0001-7882-4817 Román,Viktor;Department of Pharmacology and Drug Safety,Gedeon Richter Plc;ORCID:0000-0002-4849-3591 Lévay,György;Department of Pharmacology and Drug Safety,Gedeon Richter Plc;ORCID:0000-0002-5865-6462 |
| Description | |The human mu rhythm has been suggested to represent an important function in information processing. Rodent homologue rhythms have been assumed though no study has investigated them from the cognitive aspect yet. As voluntary goal-directed movements induce the desynchronization of mu rhythm, we aimed at exploring whether the touch-response-related brain activity during the touchscreen visual discrimination (VD) task is suitable to detect sensorimotor rhythms in healthy and cognitively impaired rats. Different doses of scopolamine or MK-801 were injected subcutaneously to male Lister Hooded rats, and epidural electroencephalography (EEG) was recorded during task performance. Arciform ~10 Hz oscillations appeared during visual processing, then two characteristic alpha/beta desynchronization-resynchronization patterns emerged predominating above the sensorimotor areas, serving different motor functions. Beyond causing cognitive impairment, both drugs supressed the touch-related upper alpha (10-15 Hz) reactivity for desynchronization. Reaction time positively correlated with movement-related alpha and beta power both in normal and impaired conditions. These results support the existence of a mu homologue rodent rhythm whose upper alpha component appeared to be modulated by cholinergic and glutamatergic mechanisms and its power change might indicate a potential EEG correlate of processing speed. The VD task can be utilized for the investigation of sensorimotor rhythms in rats. Example description that can contain linebreaks but has to maintain indentation. |
| License | Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/) |
| References |
Citation1 [doi:10.xxx/zzzz] (IsSupplementTo)
Citation2 [arxiv:mmmm.nnnn] (IsSupplementTo) Citation3 [pmid:nnnnnnnn] (IsReferencedBy) |
| Funding |
DFG, AB1234/5-6
EU, EU.12345 |
| Keywords |
Neuroscience
Visual Discrimination EEG Scopolamine MK-801 |
| Resource Type |
Dataset |
