Recordings of local field potentials from the visual and auditory cortices of male mice with a conditional reinstatement of Pcdh9 and controls.

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README.md

Pcdh9

Recordings of local field potentials from Pcdh9 male mice. The purpose of the recordings was to exploration the electrophysiological phenotype of homozygous Pcdh9 knockout and condition reinstatement.

The genotypes used were: wildtype Pcdh9 with wildtype cre (n=7), wildtype Pcdh9 with cre inserted (n=7), homozygous knock-out of Pcdh9 with wildtype cre (n=8) and homozygous knock-out of Pcdh9 with cre inserted in layer 6 of the cortex (ntsr line) (n=8).

WT/WT WT/hemi Hom/WT Hom/hemi
61857 60584 60578 64228
61901 60590 61884 64236
61834 61811 61592 64237
61893 63360 61902 64265
63358 63398 61831 64291
64229 64272 61891 64293
64301 65751 65716 65767
65752 65768

The double genotype is written as Pcdh9/ntsr-cre

Electrode configuration: Electrodes implanted bilaterally over visual (AP -4, ML +- 2.5) (ch 3 & 14) and auditory cortices (AP -2.5, ML +- 3.5) (ch 4 & 12) and unilaterally over PFC (AP 2.58 ML -1.57) (ch13). Two EMGs in neck muscles (ch 8 & 11) and ref over the cerebellum.

Structure of repository

The data contains recordings of evoked responses visual (VEP) and auditory (AEP) along with recordings of spontaneous activity for four hours (4_h). There were a total of 27 recording days over the period from May 10th 2021 to February 3rd 2022. The mice were exposed to the same battery of tests twice: at 8 weeks (first) and 22 weeks of age (second). The recording files are .EDF+ with .yaml files containing the metadata additionally there are screenshots of logs made from the recording software showing the exact carrier frequencies for each transmitter along with the package loss.

datacite.yml
Title Cortical Protocadherin-9 expression regulates multimodal sensory processing by amplifying thalamo-cortico output during wakefulness
Authors Østergaard,Freja Gam;GELIFES, Rijkuniversiteit Groningen;ORCID:0000-0001-7113-1743
Description Electrophysiological data from Pcdh9-deficient mice and mice with Pch9 reinstated in layer 6 of the cortex. Local field potentials recorded over the visual and auditory cortices.
License Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
References Østergaard: Cortical Protocadherin-9 expression regulates multimodal sensory processing by amplifying thalamo-cortico output during wakefulness [doi:tba] (IsSupplementTo)
EEGcode [url:https://github.com/FrejaGam/EEGcode] (IsReferencedBy)
Funding EU, Aims-2-Trials, IMI grant agreement No 777394
Keywords Neuroscience
Pcdh9
Electrophysiology
Sensory processing
Autism spectrum disorder
Resource Type Dataset