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-# Metadata for DOI registration according to DataCite Metadata Schema 4.1.
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-# For detailed schema description see https://doi.org/10.5438/0014
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-## Required fields
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-
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-# The main researchers involved. Include digital identifier (e.g., ORCID)
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-# if possible, including the prefix to indicate its type.
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-authors:
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- -
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- firstname: "Claudia"
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- lastname: "Aguirre"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- firstname: "Jae"
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- lastname: "Woo"
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- affiliation: "Department of Psychological and Brain Sciences, Dartmouth College"
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- firstname: "Juan Luis"
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- lastname: "Romero-Sosa"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- firstname: "Zeena"
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- lastname: "Rivera"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- firstname: "Alexandra"
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- lastname: "Tejada"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- firstname: "Joseph"
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- lastname: "Munier"
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- affiliation: "Section of Biosystems and Function, School of Dentistry, University of California, Los Angeles"
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- firstname: "Johnny"
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- lastname: "Perez"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- firstname: "Madeline"
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- lastname: "Goldfarb"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- firstname: "Kanak"
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- lastname: "Das"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- firstname: "Megan"
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- lastname: "Gomez"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- firstname: "Tony"
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- lastname: "Ye"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- firstname: "Jasmine"
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- lastname: "Pannu"
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- affiliation: "Section of Biosystems and Function, School of Dentistry, University of California, Los Angeles"
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- firstname: "Kaela"
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- lastname: "Evans"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- firstname: "Patrick"
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- lastname: "O'Neill"
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- affiliation: "Shirley and Stefan Hatos Center for Neuropharmacology, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles"
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- firstname: "Igor"
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- lastname: "Spigelman"
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- affiliation: "Section of Biosystems and Function, School of Dentistry, University of California, Los Angeles"
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- firstname: "Alireza"
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- lastname: "Soltani"
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- affiliation: "Section of Biosystems and Function, School of Dentistry, University of California, Los Angeles"
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- firstname: "Alicia"
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- lastname: "Izquierdo"
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- affiliation: "Department of Psychology, University of California, Los Angeles"
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- identifier: "ORCID:0000-0001-9897-2091"
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-# A title to describe the published resource.
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-title: "Dissociable contributions of basolateral amygdala and ventrolateral orbitofrontal cortex to flexible learning under uncertainty"
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-# Additional information about the resource, e.g., a brief abstract.
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-description:
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- Reversal learning measures the ability to form flexible associations between choice outcomes with
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- stimuli and actions that precede them. This type of learning is thought to rely on several cortical and
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- subcortical areas, including highly interconnected orbitofrontal cortex (OFC) and basolateral
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- amygdala (BLA), and is often impaired in various neuropsychiatric and substance use disorders.
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- However, unique contributions of these regions to stimulus- and action-based reversal learning have
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- not been systematically compared using a chemogenetic approach and particularly before and after
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- the first reversal that introduces new uncertainty. Here, we examined the roles of ventrolateral OFC
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- (vlOFC) and BLA during reversal learning. Male and female rats were prepared with inhibitory
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- DREADDs targeting projection neurons in these regions and tested on a series of deterministic and
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- probabilistic reversals during which they learned about stimulus identity or side (left or right)
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- associated with different reward probabilities. Using a counterbalanced within-subject design, we
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- inhibited these regions prior to reversal sessions. We assessed initial and pre-post reversal changes
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- in performance to measure learning and adjustments to reversals, respectively. We found that
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- inhibition of vlOFC, but not BLA, eliminated adjustments to stimulus-based reversals. Inhibition of
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- BLA, but not vlOFC, selectively impaired action-based probabilistic reversal learning, leaving
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- deterministic reversal learning intact. vlOFC exhibited a sex-dependent role in early adjustment to
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- action-based reversals, but not in overall learning. These results reveal dissociable roles for BLA
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- and vlOFC in flexible learning and highlight a more crucial role for BLA in learning meaningful
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- changes in the reward environment.
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-# Lit of keywords the resource should be associated with.
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-# Give as many keywords as possible, to make the resource findable.
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-keywords:
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- - stimulus learning
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- - action learning
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- - deterministic
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- - probabilistic
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- - deterministic
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- - reward learning
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- - DREADDs
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-
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-# License information for this resource. Please provide the license name and/or a link to the license.
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-# Please add also a corresponding LICENSE file to the repository.
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-license:
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- name: 'Creative Commons CC0 1.0 Public Domain Dedication'
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- url: 'https://creativecommons.org/publicdomain/zero/1.0/'
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-
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-## Optional Fields
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-
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-# Funding information for this resource.
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-# Separate funder name and grant number by comma.
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-funding:
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- - "NIH, R01 DA047870"
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- - "NIH, R21 MH122800"
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- - "NIH, R01 AA024527"
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- - "NIH, K01 DA042219"
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- - "NIH, F31 AA028183"
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- - "NIH, T32 NS115753"
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-# Related publications. reftype might be: IsSupplementTo, IsDescribedBy, IsReferencedBy.
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-# Please provide digital identifier (e.g., DOI) if possible.
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-# Add a prefix to the ID, separated by a colon, to indicate the source.
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-# Supported sources are: DOI, arXiv, PMID
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-# In the citation field, please provide the full reference, including title, authors, journal etc.
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-references:
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- -
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- id: "doi.org/10.1523/JNEUROSCI.0622-23.2023"
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- reftype: "IsDescribedBy"
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- citation: "Aguirre, C. G., Woo, J. H., Romero-Sosa, J. L., Rivera, Z. M., Tejada, A. N., Munier, J. J., Perez, J., Goldfarb, M., Das, K., Gomez, M., Ye, T., Pannu, J., Evans, K., O'Neill, P. R., Spigelman, I., Soltani, A., & Izquierdo, A. (2023). Dissociable contributions of basolateral amygdala and ventrolateral orbitofrontal cortex to flexible learning under uncertainty. The Journal of neuroscience : the official journal of the Society for Neuroscience, JN-RM-0622-23. Advance online publication. https://doi.org/10.1523/JNEUROSCI.0622-23.2023"
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-# Resource type. Default is Dataset, other possible values are Software, DataPaper, Image, Text.
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-resourcetype: Dataset
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-# Do not edit or remove the following line
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-templateversion: 1.2
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