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-# Metadata for DOI registration according to DataCite Metadata Schema 4.1.
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-# For detailed schema description see https://doi.org/10.5438/0014
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-
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-## Required fields
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-
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-# The main researchers involved. Include digital identifier (e.g., ORCID)
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-# if possible, including the prefix to indicate its type.
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-authors:
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- -
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- firstname: 'Xiaofei'
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- lastname: 'Guan'
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- affiliation: 'Burke Neurological Institute'
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- id: 'ORCID:0000-0002-3675-4344'
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- -
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- firstname: 'Yanjie'
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- lastname: 'Zhu'
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- affiliation: 'Burke Neurological Institute'
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- -
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- firstname: 'Jian'
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- lastname: 'Zhong'
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- affiliation: 'Burke Neurological Institute'
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- id: 'ORCID:0000-0003-2031-232X'
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- -
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- firstname: 'Edmund'
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- lastname: 'Hollis'
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- affiliation: 'Burke Neurological Institute'
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- id: 'ORCID:0000-0002-4535-4668'
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-
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-# A title to describe the published resource.
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-title: 'Neuropathic pain in a chronic CNS injury model is mediated by corticospinal-targeted spinal interneurons'
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-
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-# Additional information about the resource, e.g., a brief abstract.
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-description: 'Chronic neuropathic pain is a persistent and debilitating outcome of traumatic central nervous system injury, affecting up to 80% of individuals with chronic injury. Post-injury pain is refractory to clinical treatments due to the limited understanding of the brain-spinal cord circuits that underlie pain signal processing. The corticospinal tract (CST) plays critical roles in sensory modulation during skilled movements and tactile sensation; however, a direct role for the CST in injury-associated neuropathic pain is unclear. Here we show that complete, selective CST transection at the medullary pyramids leads to hyperexcitability within lumbar deep dorsal horn and hindlimb allodynia in chronically injured adult mice. Chemogenetic regulation of CST-targeted lumbar spinal interneurons demonstrates that dysregulation of activity in this circuit underlies the development of tactile allodynia in chronic injury. Our findings shed light on an unrecognized circuit mechanism implicated in CNS injury-induced neuropathic pain and provide a novel target for therapeutic intervention.'
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-# Lit of keywords the resource should be associated with.
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-# Give as many keywords as possible, to make the resource findable.
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-keywords:
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- - 'Neuropathic pain'
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- - 'Spinal cord injury'
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- - 'Sensory modulation'
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- - 'Tactile allodynia'
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-
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-# License information for this resource. Please provide the license name and/or a link to the license.
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-# Please add also a corresponding LICENSE file to the repository.
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-license:
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- name: "Creative Commons CC0 1.0 Public Domain Dedication"
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- url: "https://creativecommons.org/publicdomain/zero/1.0/"
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-## Optional Fields
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-
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-# Funding information for this resource.
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-# Separate funder name and grant number by comma.
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-funding:
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- - 'Craig H. Neilsen Foundation, 998694'
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- - 'NYS DoH, C30844GG'
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- - 'National Institutes of Health, R01 NS099568'
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- - 'National Institutes of Health, DP2 NS106663'
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- - 'National Institutes of Health, R01 NS105725'
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-# Related publications. reftype might be: IsSupplementTo, IsDescribedBy, IsReferencedBy.
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-# Please provide digital identifier (e.g., DOI) if possible.
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-# Add a prefix to the ID, separated by a colon, to indicate the source.
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-# Supported sources are: DOI, arXiv, PMID
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-# In the citation field, please provide the full reference, including title, authors, journal etc.
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-references:
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- -
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- id: 'doi.org/10.1101/2024.04.11.589134'
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- reftype: IsSupplementTo
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- citation: Guan X, Zhu Y, Zhong J, and Hollis E (2024) Neuropathic pain in a chronic CNS injury model is mediated by corticospinal-targeted spinal interneurons. doi: https://doi.org/10.1101/2024.04.11.589134
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-# Resource type. Default is Dataset, other possible values are Software, DataPaper, Image, Text.
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-resourcetype: Dataset
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-# Do not edit or remove the following line
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-templateversion: 1.2
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