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Update 'datacite.yml'

Edmund Hollis II 1 month ago
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commit
4135e53d72
1 changed files with 25 additions and 19 deletions
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      datacite.yml

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datacite.yml

@@ -1,37 +1,43 @@
 authors:
   -
-    firstname: 'Yue'
-    lastname: 'Li'
+    firstname: 'Xiaofei'
+    lastname: 'Guan'
     affiliation: 'Burke Neurological Institute'
-    id: 'ORCID:0000-0002-9594-5802'
+    id: 'ORCID:0000-0002-3675-4344'
+  -
+    firstname: 'Yanjie'
+    lastname: 'Zhu'
+    affiliation: 'Burke Neurological Institute'
+  -
+    firstname: 'Jian'
+    lastname: 'Zhong'    
+    affiliation: 'Burke Neurological Institute'
+    id: 'ORCID:0000-0003-2031-232X'
   -
     firstname: 'Edmund'
     lastname: 'Hollis'
     affiliation: 'Burke Neurological Institute'
     id: 'ORCID:0000-0002-4535-4668'
-title: 'Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice'
-description: "Motor control requires precise temporal and\nspatial encoding across distinct motor centers that is refined through the\nrepetition of learning. The recruitment of motor regions requires modulatory\ninput to shape circuit activity. Here we identify a role for the baso-cortical cholinergic\npathway in the acquisition of a coordinated motor skill in mice. Targeted\ndepletion of basal forebrain cholinergic neurons results in significant impairments\nin training on the rotarod task of coordinated movement. Cholinergic\nneuromodulation is required during training sessions as chemogenetic\ninactivation of cholinergic neurons also impairs task acquisition. Rotarod\nlearning is known to drive refinement of corticostriatal neurons arising in both\nmedial prefrontal cortex (mPFC) and motor cortex, and we have found that\ncholinergic input to both motor regions is required for task acquisition. Critically,\nthe effects of cholinergic neuromodulation are restricted to the acquisition\nstage, as depletion of basal forebrain cholinergic neurons after learning does\nnot affect task execution. Our\nresults indicate a critical role for cholinergic neuromodulation of distant cortical\nmotor centers during coordinated motor learning."
+title: 'Neuropathic pain in a chronic CNS injury model is mediated by corticospinal-targeted spinal interneurons'
+description: 'Chronic neuropathic pain is a persistent and debilitating outcome of traumatic central nervous system injury, affecting up to 80% of individuals with chronic injury. Post-injury pain is refractory to clinical treatments due to the limited understanding of the brain-spinal cord circuits that underlie pain signal processing. The corticospinal tract (CST) plays critical roles in sensory modulation during skilled movements and tactile sensation; however, a direct role for the CST in injury-associated neuropathic pain is unclear. Here we show that complete, selective CST transection at the medullary pyramids leads to hyperexcitability within lumbar deep dorsal horn and hindlimb allodynia in chronically injured adult mice. Chemogenetic regulation of CST-targeted lumbar spinal interneurons demonstrates that dysregulation of activity in this circuit underlies the development of tactile allodynia in chronic injury. Our findings shed light on an unrecognized circuit mechanism implicated in CNS injury-induced neuropathic pain and provide a novel target for therapeutic intervention.'
 keywords:
-  - 'Basal forebrain'
-  - 'Cholinergic neurons'
-  - 'Motor learning'
-  - 'Coordination'
-  - 'Rotarod'
-  - 'Forelimb reach'
-  - 'Prefrontal cortex'
-  - 'Motor cortex'
+  - 'Neuropathic pain'
+  - 'Spinal cord injury'
+  - 'Sensory modulation'
+  - 'Tactile allodynia'
 license:
   name: 'Creative Commons CC0 1.0 Public Domain Dedication'
   url: 'https://creativecommons.org/publicdomain/zero/1.0/'
 funding:
-  - 'Burke foundation'
-  - 'NIH, DP2 NS106663'
-  - 'New York State Department of Health SCIRB, C32633GG'
+  - 'Craig H. Neilsen Foundation, 998694'
+  - 'NYS DoH, C30844GG'
+  - 'National Institutes of Health, R01 NS099568'
+  - 'National Institutes of Health, DP2 NS106663'
+  - 'National Institutes of Health, R01 NS105725'
 references:
   -
-    id: 'doi:10.1523/JNEUROSCI.1152-21.2021'
-    id: 'pmid:34750228'
+    id: 'doi.org/10.1101/2024.04.11.589134'
     reftype: IsSupplementTo
-    citation: Li and Hollis. Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice. J Neurosci. 2021 Dec 8;41(49):10148-10160.
+    citation: Guan X, Zhu Y, Zhong J, and Hollis E (2024) Neuropathic pain in a chronic CNS injury model is mediated by corticospinal-targeted spinal interneurons. doi: https://doi.org/10.1101/2024.04.11.589134
 resourcetype: Dataset
 templateversion: 1.2