| Title |
Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer's Disease and Related Dementias |
| Authors |
Reekes,Tyler H.;Louisiana State University Health Shreveport;ORCID:0000-0003-4131-1094
Ledbetter,Christina R.;Louisiana State University Health Shreveport;ORCID:0000-0001-8581-6065
Pardue,Sibile;Louisiana State University Health Shreveport;ORCID:0000-0002-5133-7901
Alexander,J. Steven;Louisiana State University Health Shreveport;ORCID:0000-0001-6975-3711
Stokes,Karen Y.;Louisiana State University Health Shreveport;ORCID:0000-0002-7612-3467
Bhuiyan,Mohammad Alfrad Nobel;Louisiana State University Health Shreveport;ORCID:0000-0002-6011-2624
Patterson,James C.;Louisiana State University Health Shreveport;ORCID:0000-0001-5709-2557
Lofton,Katelyn T.;Louisiana State University Health Shreveport;ORCID:0000-0001-9620-1162
Kevil,Christopher G.;Louisiana State University Health Shreveport;ORCID:0000-0003-0863-7260
Disbrow,Elizabeth A.;Louisiana State University Health Shreveport;ORCID:0000-0002-2133-3221
|
| Description |
Emerging evidence indicates that vascular stress
is an important contributor to the pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide (H2S) and its metabolites (acid-labile (e.g., iron-sulfur clusters) and bound (e.g., per-, poly-sulfides)) have been shown to regulate both vascular and neuronal homeostasis. We recently reported that elevated plasma sulfides were associated with cognitive dysfunction and microvascular disease in ADRD; here we extend our previous work to show associations between elevated sulfides and magnetic resonance-based metrics of brain atrophy and white matter integrity. Elevated bound sulfides were associated with decreased measures of gray matter volume, while increased acid labile sulfides were associated with measures of decreased white matter integrity and increased ventricular volume. These findings are consistent with a ‘toxic’ sulfide model of ADRD. Our results are consistent with a compensatory sulfide response to oxidative stress.
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| License |
Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
|
| References |
Reekes, T. H., Ledbetter, C. R., Pardue, S., Alexander, J. S., Stokes, K. Y., Bhuiyan, M. A. N., Patterson, J. C., Lofton, K. T., Kevil, C. G., & Disbrow, E. A. (2023). Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer’s Disease and Related Dementias. Submitted to Redox Biology. [doi::tba] (IsSupplementTo)
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| Funding |
NIH, 3P2012130701A1S1
NIH, HL149264-01A1
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| Keywords |
Alzheimer's Disease
hydrogen sulfide
dementia
cortical thickness
white matter integrity
neuroimaging
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| Resource Type |
Dataset
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