We use cookies to ensure you get the best experience on our website
Startsida Utforska Hjälp News
Registrera dig Logga in
doi
/
2023_Blaschke_Stroke_tDCS_rsfMRI
forkad från stejobla/2023_Blaschke_Stroke_tDCS_rsfMRI
DOI
10.12751/g-node.nbm9qr
1
0
Fork 0
Filer

This is a dataset of longitudinal MRI (T2w and rs-fMRI) in mice after cortical stroke (photothrombosis) for up to four weeks and early cathodal tDCS compared to sham stimulation and healthy controls.

Gren: synced/master
Grenar Taggar
2023_Blaschk...
G-Node DOI cb0b87932e gin commit from srv11 1 år sedan
.datalad d7e4da4d19 [DATALAD] new dataset 1 år sedan
input cb0b87932e gin commit from srv11 1 år sedan
results b41bc74cf6 [DATALAD] Recorded changes 1 år sedan
scripts b41bc74cf6 [DATALAD] Recorded changes 1 år sedan
.gitattributes d7e4da4d19 [DATALAD] new dataset 1 år sedan
LICENSE d139d5dc2d add readme and subj list 1 år sedan
datacite.yml f7cc1e1a28 Add information for publishing with DataCite 1 år sedan
graphical_abstract.jpg d139d5dc2d add readme and subj list 1 år sedan
readme.md 68e72520cd [DATALAD] Recorded changes 1 år sedan
~$PT_tDCS_ID_list.xlsx b41bc74cf6 [DATALAD] Recorded changes 1 år sedan

readme.md

Accompaning Dataset: Blaschke et al., Stroke 2023

doi: 10.1161/STROKEAHA.123.042808

Transcranial Direct Current Stimulation Reverses Stroke-Induced Network Alterations in Mice.

Graphical Abstract

This is a dataset of longitudinal MRI (T2w and rs-fMRI) in mice after cortical stroke (photothrombosis) for up to four weeks and early cathodal tDCS compared to sham stimulation and healthy controls.

  • All inputs (MRI raw and processed, Behavior data) are located in inputs/.

  • All custom code is located in code/.

  • All of the final results (of any kind) is located in results/.

Abstract:

Background: Beyond focal effects, stroke lesions impact the function of distributed networks. We here investigated (1) whether transcranial direct current stimulation (tDCS) alters the network changes induced by cerebral ischemia and (2) whether functional network parameters predict the therapeutic efficacy of tDCS in a mouse model of focal photothrombotic stroke.

Methods: Starting 3 days after stroke, cathodal tDCS (charge density=39.6 kC/m²) was applied over 10 days in male C57Bl/6J mice under light anesthesia over the lesioned sensory-motor cortex. Functional connectivity (resting-state functional magnetic resonance imaging) was evaluated for up to 28-day poststroke, with global graph parameters of network integration computed.

Results: Ischemia induced a subacute increase in connectivity accompanied by a significant reduction in characteristic path length, reversed by 10 days of tDCS. Early measures of functional network alterations and the network configuration at prestroke baseline predicted spontaneous and tDCS-augmented motor recovery.

Discussion: Stroke induces characteristic network changes throughout the brain that can be detected by resting-state functional magnetic resonance imaging. These network changes were, at least in part, reversed by tDCS. Moreover, early markers of a network impairment and the network configuration before the insult improve the prediction of motor recovery.

Keywords

  • animals
  • brain
  • ischemia
  • magnetic resonance imaging
  • mice
  • functional connectivity
  • transcranial direct current stimulation
datacite.yml
Title Longitudinal MRI data (T2w and rs-fMRI) after cortical stroke and cathodal transcranial direct current stimulation (tDCS) in mice
Authors Blaschke,Stefan;University Hospital Cologne;ORCID:0000-0001-8643-3824
Rueger,Maria Adele;University Hospital Cologne;ORCID:0000-0001-8036-395X
Description 'Longitudinal T2-weighted MRI, rs-fMRI and behavorial data (baseline and up to 4 weeks after stroke) in the photothrombosis model and transcranial direct current stimulation (cathodal tDCS) in mice'
License CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/)
References Blaschke SJ, Vlachakis S, Pallast N, Walter HL, Volz LJ, Wiedermann D, Fink GR, Hoehn M, Aswendt M, Schroeter M, Rueger MA. Transcranial Direct Current Stimulation Reverses Stroke-Induced Network Alterations in Mice. Stroke. 2023 Jun 28. doi: 10.1161/STROKEAHA.123.042808 [doi:10.1161/STROKEAHA.123.042808] (IsSupplementTo)
Funding DFG, 431549029–SFB 1451
Marga und Walter Boll Stiftung, #210/10/15
Keywords ischemia
brain
magnetic resonance imaging
mice
transcranial direct currrent stimulation
functional connectivity
motor recovery
Resource Type Dataset