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- : tonic current with rectification
- : based on Pavlov et al (J Neuro 2009)
- NEURON{
- SUFFIX tonic
- NONSPECIFIC_CURRENT i
- RANGE i, v, a, b, g, e_gaba}
- PARAMETER{
- g = 0.001 (siemens/cm2)
- e_gaba = -80 (millivolt)
- }
- ASSIGNED{
- v (millivolt)
- i (milliampere)
- a (/ms)
- b (/ms)}
- STATE{o c}
- BREAKPOINT{
- SOLVE kin METHOD sparse
- i = g*o*(v-e_gaba)}
- INITIAL {SOLVE kin STEADYSTATE sparse}
- KINETIC kin{
- rates(v)
- ~ o<->c (b, a) : b is forward rate constant, a backward
- CONSERVE o+c=1}
- PROCEDURE rates(v(millivolt)) {
- LOCAL x, y
- UNITSOFF
- x = 0.1*(v+20)
- if (fabs(x)>1e-6){
- a = (50*x)/(1-exp(-x))
- } else{
- a=0.25*(v^2+(20*v)+200)
- }
- y = -0.08*(v-10)
- if(fabs(x)>1e-6){
- b = (20*y)/(1-exp(-y))
- } else{
- b = -0.064*(v^2-(45*v)+37.5)
- }
- UNITSON}
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