|
|
@@ -1,3 +1,21 @@
|
|
|
# Anesthesia_CA1
|
|
|
|
|
|
-Calcium imaging and electrophysiology data from hippocampal CA1 during wakefulness and under various general anesthetics
|
|
|
+This repository contains data related to the article "Anesthetics fragment hippocampal network activity, alter spine dynamics and affect memory consolidation" (https://www.biorxiv.org/content/10.1101/2020.06.05.135905v1).
|
|
|
+
|
|
|
+We provide calcium imaging and electrophysiology data from hippocampal CA1 during wakefulness, sleep and under various general anesthetics.
|
|
|
+Following the structure of the repository, the dataset contains:
|
|
|
+- LFP and SUA recordings from 4 mice under Isoflurane, Keta/Xyl and MMF anesthesia (electrophysiology folder)
|
|
|
+- 189 distinct 2-photon calcium imaging recordings from 7 different mice under Isoflurane, Keta/Xyl and MMF anesthesia (calcium imaging folder)
|
|
|
+- LFP and SUA recordings in awake and sleep conditions (with sleep scoring) from 7 and 4 mice respectively (Sleep Data/LFP and Sleep Data/SUA folders)
|
|
|
+- 74 distinct 2-photon calcium imaging recordings from 3 mice in awake and sleep conditions (Sleep Data/calcium imaging folder)
|
|
|
+
|
|
|
+## Data structure info
|
|
|
+
|
|
|
+Most data structure should be self explanatory / inferrable from the description in the manuscript, but some useful information is provided in the respective "meta_data" excel files.
|
|
|
+
|
|
|
+### Miscellaneous
|
|
|
+
|
|
|
+- information about the numpy calcium imaging files can be found in the suite2p documentation page (https://suite2p.readthedocs.io/en/latest/)
|
|
|
+- for LFP data, only the CA1 reversal channel is provided
|
|
|
+- LFP data has a sampling rate of 32kHz for the "anesthesia" recordings, and 320 Hz for the sleep recordings
|
|
|
+- code used for analysis/stats and stats dataset can be found at https://github.com/mchini/Yang_Chini_et_al and https://github.com/OpatzLab/HanganuOpatzToolbox
|
