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# Long-term in vivo application of a potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus
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-Here we provide the electrophysiological datasets and Python scripts used to analyze the data, which underlie the conclusions in our paper about application of the novel potassium channel-based optogenetic silencer, PACK, *in vivo* (Kleis et al., submitted to BMC Biology in 2021). Local field potentials (LFPs) were recorded with wire electrodes, which were chronically implanted into the hippocampus of healthy or non-epileptic adult male mice. The LFPs were acquired from freely behaving mice, which were placed into the recording arena for three hours either without illumination (reference recording) or with an optogenetic stimulation during the second hour. We had six experimental groups, which are presented in the file named "LFP_nomenclature_and_datasets.xlsx". Further details about the experimental groups and methods are presented in the published article.
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+Here we provide the electrophysiological datasets and Python scripts, which underlie the data analysis and conclusions in our paper about the novel potassium channel-based optogenetic silencer, PACK, and its application *in vivo* (Kleis et al., submitted to BMC Biology in 2021). We recorded local field potentials (LFPs) with wire electrodes, which were chronically implanted into the hippocampus of healthy or non-epileptic adult male mice. The LFPs were acquired from freely behaving mice, which were placed into the recording arena for three hours either without illumination (reference recording) or with an optogenetic stimulation (at 0.05 Hz or 0.1 Hz) during the second hour. We had six experimental groups, which are presented in the file named "LFP_nomenclature_and_datasets.xlsx". Further details about the experimental groups and methods are presented in the published article.
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-The datasets contain LFPs resampled at 500 Hz in .h5 file format. We uploaded LFPs acquired at the contralateral hippocampal electrode ('HCc') of the non-epileptic mice (saline groups). For epileptic mice (kainate groups), data from ipsilateral ('HCi') and contralateral hippocampal electrodes are presented.
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+The datasets contain LFPs resampled at 500 Hz in .h5 file format. We uploaded LFPs acquired at the contralateral hippocampal electrode ('HCc') of the non-epileptic mice (saline-injected groups). For epileptic mice (kainate-injected groups), data from ipsilateral ('HCi') and contralateral hippocampal electrodes are presented.
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-The Python codes that were used to analyze the data and generate the figures, can be found in three scripts:
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+The Python codes that were used to analyze the data and generate the figures can be found in three scripts:
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**Script 1:** contains the function for calculating line length. Script 1 was used to generate subfigures in Fig.1, Fig. 4, Fig.S2, Fig. S3, and Fig. S4.
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