Behaviour and EEG recorded during the touchscreen Visual Disrimination task performance in rats

Diana Kostyalik b6c5c330fb Frissítés "datacite.yml" 2 anni fa
Behavioural data 335ca3d7f2 Fájlok feltöltése 'Behavioural data' 2 anni fa
MK-801_EEG fd35e68e53 Fájlok feltöltése 'MK-801_EEG' 2 anni fa
Scopolamine_EEG 594e1b1c78 Fájlok feltöltése 'Scopolamine_EEG' 2 anni fa
LICENSE 4adf2d015c Initial commit 2 anni fa
README.md 4adf2d015c Initial commit 2 anni fa
datacite.yml b6c5c330fb Frissítés "datacite.yml" 2 anni fa

README.md

VD-EEG

Behaviour and EEG recorded during the touchscreen Visual Disrimination task performance in rats

datacite.yml
Title Response-related sensorimotor rhythms under scopolamine and MK-801 exposures in the touchscreen Visual Discrimination test in rats
Authors Kostyalik,Diana;Cognitive Pharmacology Laboratory, Department of Pharmacology and Drug Safety, Gedeon Richter Plc;ORCID:0000-0003-3552-4528
Kelemen,Kristóf;Cognitive Pharmacology Laboratory, Department of Pharmacology and Drug Safety, Gedeon Richter Plc;ORCID:0000-0001-7378-0843
Description |The human mu rhythm has been suggested to represent an important function in information processing. Rodent homologue rhythms have been assumed though no study has investigated them from the cognitive aspect yet. As voluntary goal-directed movements induce the desynchronization of mu rhythm, we aimed at exploring whether the touch-response-related brain activity during the touchscreen visual discrimination (VD) task is suitable to detect sensorimotor rhythms in healthy and cognitively impaired rats. Different doses of scopolamine or MK-801 were injected subcutaneously to male Lister Hooded rats, and epidural electroencephalography (EEG) was recorded during task performance. Arciform ~10 Hz oscillations appeared during visual processing, then two characteristic alpha/beta desynchronization-resynchronization patterns emerged predominating above the sensorimotor areas, serving different motor functions. Beyond causing cognitive impairment, both drugs supressed the touch-related upper alpha (10-15 Hz) reactivity for desynchronization. Reaction time positively correlated with movement-related alpha and beta power both in normal and impaired conditions. These results support the existence of a mu homologue rodent rhythm whose upper alpha component appeared to be modulated by cholinergic and glutamatergic mechanisms and its power change might indicate a potential EEG correlate of processing speed. The VD task can be utilized for the investigation of sensorimotor rhythms in rats. Example description that can contain linebreaks but has to maintain indentation.
License Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
References Citation1 [doi:10.xxx/zzzz] (IsSupplementTo)
Citation2 [arxiv:mmmm.nnnn] (IsSupplementTo)
Citation3 [pmid:nnnnnnnn] (IsReferencedBy)
Funding DFG, AB1234/5-6
EU, EU.12345
Keywords Neuroscience
Visual Discrimination
EEG
Scopolamine
MK-801
Resource Type Dataset