Longitudinal study monitoring the progression of any electrophysiological phenotype related to sensory processing in the Nrxn1α knock-out model. The study contains two data sets (raw):
The recordings were made in TainiLive. The recording files are of the .edf+ type, meta data is provided as .yaml files and screenshots of the recording logs are available containing the exact transmitter frequency of each recording. The 24-hour recordings contain data from motion sensors recorded with Spike2 (CED) as .smrx format.
Electrodes implanted bilaterally over visual (AP -4, ML +- 2.5) (ch 3 & 14) and auditory cortices (AP -2.5, ML +- 3.5) (ch 4 & 12) and unilaterally over PFC (AP 2.58 ML -1.57) (ch13). Two EMGs in neck muscles (ch 8 & 11) and reference over the cerebellum.
Due to software updates during the study the sampling frequency is not the same in all recordings
A few files were recorded with the sampling frequency: 2789.3 Hz
The genotype of the animal is presented below:
Batch # | WT | Het | Hom |
---|---|---|---|
1 | 51333 | 51334 | 51372 |
51346 | 51341 | 51383 | |
51355 | 51343 | 51389 | |
51363 | 51344 | 51391e | |
51375 | 51345 | 51403 | |
51413 | 51351 | 51405 | |
51352 | |||
2 | 55970 | 55949 | 55948 |
55979 | 55963 | 55964 | |
55984 | 55983 | 55971 | |
55985 | 55978 | ||
3 | 57738 | 57767 | 57737 |
57753 | 57781 | 57752 | |
57760 | 57762 | ||
57763 | 57766 | ||
57782 | |||
Total n | 14 | 13 | 13(14) |
e - poor signal at last recording
Longitudinal study of how acute administration of arbaclofen affect the Nrxn1α knock-out model. Arbaclofen (2 mg/kg) i saline was administered in a cross-over design at 8 weeks and 22 weeks of age.
The data includes a dose adjustment pilot (folder: VEP/additional/dose-response) with doses 3 mg/kg and 4 mg/kg and VEP gating at 30 weeks (folder: VEP/additional/aging).
Electrode configuration was the same as above for most of the animals, but for animals: 74979,74980,74981,74983,75023 The electrode configuration was as follows:
Electrodes implanted bilaterally over visual (AP -4, ML +- 2.5) (ch 14 & 4) and auditory cortices (AP -2.5, ML +- 3.5) (ch 13 & 5) and unilaterally over PFC (AP 2.58 ML -1.57) (ch 3). Two EMGs in neck muscles (ch 8 & 11) and ref over the cerebellum.
First recording (visual and auditory) of first time point:
First recording of second time point:
WT | Het | Hom |
---|---|---|
74959 | 74924 | 74930 |
74967 | 74960 | 74931 |
74968 | 74965 | 74958 |
74986e | 74966 | 74981 |
74988 | 74979 | 74983 |
75024 | 74980 | 74985 |
74989 | 75023 | |
75032 | 75031 | |
75033 | ||
n=6 | 8 | 9 |
e - only first time point