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In this study, we induced cortical ischemic stroke by photothrombosis in the left sensorimotor cortex of adult C57BL/6J mice. After collecting dMRI data of the mice at different time points after stroke, we visualize specific WM tracts such as the CST and the corpus callosum (CC) with Diffusion Tensor Imaging (DTI) in the program DSI-Studio. We can then calculate diffusion metrics such as fractional anisotropy (FA), which can reveal axonal changes. Comparing these parameters, we aim to characterize SND in selected WM tracts after stroke. One focus is on identifying a correlation between the time past the stroke and the extent of SND, as well as a correlation between SND and motor impairment or stroke recovery.
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