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{"sheet":"Risk factors","index":0,"n_rows":137,"n_cols":14,"rows_kept":137,"cut":false,"hidden":false,"merged":[]}
["Risk factors stratified according to sex/gender in young ischemic stroke patients",{"$nulls":7},"Female","Male"]
["Variable/Characteristic","Total n with condition/valid n (%)","Female (n=270)","Male (n=419)","two-tailed p-value",null,null,"Hypertension",80,156]
["Modifiable risk factors",{"$nulls":6},"Diabetes",23,35]
["Hypertension","236/689 (34.3)","80/270 (29.6)","156/419 (37.2)",4.8000000000000001E-2,null,null,"Dyslipidemia",119,238]
["Diabetes mellitus","58/682 (8.5)","23/265 (8.7)","35/417 (8.4)",0.9,null,null,"Smoking",87,184]
["Dyslipidemia","357/673 (53.0)","119/262 (45.4)","238/411 (57.9)",2E-3,null,null,"Atrial fibrillation",7,14]
["Smoking","271/672 (40.3))","87/263 (33.1)","184/409 (45.0)",2E-3,null,null,"CHD",5,27]
["Atrial fibrillation","21/688 (3.1)","7/270 (2.6)","14/418 (3.3)",0.7,null,null,"History of stroke",16,43]
["Coronary heart disease","32/688 (4.7)","5/270 (1.9)","27/418 (6.5)",5.0000000000000001E-3,null,null,"Underweight",9,8]
["History of stroke","59/680 (8.7)","16/264 (6.1)","43/416 (10.3)",7.0000000000000007E-2,null,null,"Overweight",57,167]
["Underweight (BMI < 18.5 kg/m2)","17/689 (1.2)","9/270 (3.3)","8/419 (1.9)",0.3,null,null,"Obesity",63,83]
["Overweight (BMI ≥ 25 kg/m2)","224/680 (32.9)","57/266 (21.4)","167/414 (40.3)","<0.001",null,null,"SAS",18,71]
["Obesity (BMI ≥ 30 kg/m2)","146/646 (22.6)","63/257 (24.5)","83/389 (21.3)",0.4,null,null,"Alcohol overuse",12,40]
["Sleep apnea syndrome","89/444 (20.0)","18/176 (10.2)","71/268 (26.5)","<0.001",null,null,"Substance abuse",4,31]
["Alcohol overuse","52/514 (10.1)","12/195 (6.2)","40/319 (12.5)",0.02]
["Substance abuse","35/514 (6.8)","4/194 (2.1)","31/320 (9.7)",1E-3]
["PFO","197/488 (40.4)","74/192 (38.5)","123/296 (41.6)",0.6]
["Non-modifiable risk factors"]
["Family history of stroke","118/538 (21.9)","48//213 (22.5)","70/325 (21.5)",0.8,null,null,"Family history of stroke",48,70]
["Family history of CHD","116/521 (22.3)","49/206 (23.8)","67/315 (21.3)",0.5,null,null,"Family history of CHD",49,67]
{"$rows_empty":35}
["Risk factors stratified according to sex/gender in young ischemic stroke patients"]
["General population",{"$nulls":5},"Age 16-35y",null,null,null,"Age 36-55y"]
["Variable/ Characteristic","n of total (t=689) (%)","Total n with condition/ valid n (%)","Female (n=270)","Male (n=419)","two-tailed p-value","Total n with condition/ valid n (%)","Female (n=64)","Male (n=55)","two-tailed p-value","Total n with condition/ valid n (%)","Female (n=206)","Male (n=364)","two-tailed p-value"]
["Modifiable risk factors"]
["Hypertension","689 (100)","236/689 (34.3)","80/270 (29.6)","156/419 (37.2)",0.05,"9/119 (7.6)","3/64 (4.7)","6/55 (10.9)",0.3,"227/570 (39.8)","77/206 (37.4)","150/364 (41.2)",0.4]
["Diabetes mellitus","682 (99.0)","58/682 (8.5)","23/265 (8.7)","35/417 (8.4)",0.9,"1/116 (0.9)","0/61 (0.0)","1/55 (1.8)",0.5,"57/566 (10.1)","23/204 (11.3)","34/362 (9.4)",0.5]
["Dyslipidemia","673 (97.7)","357/673 (53.0)","119/262 (45.4)","238/411 (57.9)",2E-3,"35/116 (30.2)","16/62 (25.8)","19/54 (35.2)",0.3,"322/557 (57.8)","103/200 (51.5)","219/357 (61.3)",0.03]
["Smoking","672 (97.5)","271/672 (40.3)","87/263 (33.1)","184/409 (45.0)",2E-3,"39/17 (33.3)","17/63 (27.0)","22/54 (40.7)",0.1,"232/555 (41.8)","70/200 (35.0)","162/355 (45.6)",0.02]
["Atrial fibrillation","688 (99.9)","21/688 (3.1)","7/270 (2.6)","14/418 (3.3)",0.7,"0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1,"21/569 (3.7)","7/206 (3.4)","14/363 (3.9)",1]
["Coronary heart disease","688 (99.9)","32/688 (4.7)","5/270 (1.9)","27/418 (6.5)",5.0000000000000001E-3,"0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1,"32/569 (5.6)","5/206 (2.4)","27/363 (7.4)",0.01]
["History of stroke","680 (98.7)","59/680 (8.7)","16/264 (6.1)","43/416 (10.3)",7.0000000000000007E-2,"10/116 (8.6)","5/61 (8.2)","5/55 (9.1)",1,"49/564 (8.7)","11/203 (5.4)","38/361 (10.5)",0.04]
["History of TIA",{"$nulls":5},"6/96 (6.3)","3/52 (3.1)","3/44 (3.1)",1,"30/460 (6.5)","11/169 (6.5)","19/291 (6.5)",1]
["Underweight a","640 (92.9)","17/640 (2.7)","9/254 (3.5)","8/386 (2.1)",0.3,"5/113 (4.4)","3/61 (4.9)","2/52 (3.8)",1,"12/527 (2.3)","6/193 (3.1)","6/334 (1.8)",0.4]
["Overweight b","640 (92.9)","226/640 (35.3)","57/254 (22.4)","169/386 (43.8)","<0.001","29/113 (25.7)","13/61 (21.3)","16/52 (30.8)",0.3,"197/527 (37.4)","44/193 (22.8)","153/334 (45.8)","<0.001"]
["Obesity c","640 (92.9)","140/640 (21.9)","61/254 (24.0)","79/386 (20.5)",0.3,"17/113 (15.0)","6/61 (9.8)","11/52 (21.2)",0.1,"123/527 (23.3)","55/193 (28.5)","68/334 (20.4)",0.04]
["Sleep apnea syndrome","444 (64.4)","89/444 (20.0)","18/176 (10.2)","71/268 (26.5)","<0.001","7/82 (8.5)","0/40 (0.0)","7/42 (16.7)",0.01,"82/421 (19.5)","18/152 (11.8)","64/269 (23.8)",3.0000000000000001E-3]
["Alcohol overuse","514 (74.6)","52/514 (10.1)","12/195 (6.2)","40/319 (12.5)",0.02,"1/89 (1.1)","0/48 (0.0)","1/41 (2.4)",0.5,"51/425 (12.0)","12/147 (8.2)","39/278 (14.0)",0.09]
["Substance abuse","514 (74.6)","35/514 (6.8)","4/194 (2.1)","31/320 (9.7)",1E-3,"3/89 (3.4)","0/48 (0.0)","3/41 (7.3)",0.09,"32/425 ((7.5)","4/146 (2.7)","28/279 (10.0)",6.0000000000000001E-3]
["Cervical dissection","687 (99.7)","117/687 (17.0)","45/270 (16.7)","72/417 (17.3)",0.9,"30/115 (26.1)","20/61 (32.8)","10/54 (18.5)",0.09,"86/561 (15.3)","24/203 (11.8)","62/358 (17.3)",0.09]
["PFO","488 (70.8)","197/488 (40.4)","74/192 (38.5)","123/296 (41.6)",0.6,"36/80 (45.0)","17/39 (43.6)","19/41 (46.3)",0.9,"161/408 (39.5)","57/153 (37.3)","104/255 (40.8)",0.5]
["Pregnancy/Puerperium",null,null,"13/268 (4.9)",null,null,null,"12/61 (19.6)",null,null,null,"1/207 (0.5)"]
["Contraceptives or HRT",null,null,"35/269 (13.0)",null,null,null,"15/61 (24.6)",null,null,null,"20/207 (9.7)"]
["Non modifiable risk factors"]
["Family history of stroke","538 (78.1)","118/538 (21.9)","48//213 (22.5)","70/325 (21.5)",0.8,"22/102 (21.6)","14/57 (24.6)","8/45 (17.8)",0.5,"96/436 (22.0)","34/156 (21.8)","62/280 (22.1)",1]
["Family history of CHD","521 (75.6)","116/521 (22.3)","49/206 (23.8)","67/315 (21.3)",0.5,"15/100 (15.0)","7/55 (12.7)","8/45 (17.8)",0.6,"101/421 (24.0)","42/151 (27.8)","59/270 (21.9)",0.2]
[]
["a BMI < 18.5 kg/m2"]
["b BMI ≥ 25 kg/m2"]
["c BMI ≥ 30 kg/m2"]
[]
[]
["Age 16-35y"]
["Variable/ Characteristic","Total n with condition/ valid n (%)","Female (n=64)","Male (n=55)","two-tailed p-value"]
["Modifiable risk factors"]
["Hypertension","9/119 (7.6)","3/64 (4.7)","6/55 (10.9)",0.3]
["Diabetes mellitus","1/116 (0.9)","0/61 (0.0)","1/55 (1.8)",0.5]
["Dyslipidemia","35/116 (30.2)","16/62 (25.8)","19/54 (35.2)",0.3]
["Smoking","39/17 (33.3)","17/63 (27.0)","22/54 (40.7)",0.1]
["Atrial fibrillation","0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1]
["Coronary heart disease","0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1]
["History of stroke","10/116 (8.6)","5/61 (8.2)","5/55 (9.1)",1]
["History of TIA","6/96 (6.3)","3/52 (3.1)","3/44 (3.1)",1]
["Underweight a","5/113 (4.4)","3/61 (4.9)","2/52 (3.8)",1]
["Overweight b","29/113 (25.7)","13/61 (21.3)","16/52 (30.8)",0.3]
["Obesity c","17/113 (15.0)","6/61 (9.8)","11/52 (21.2)",0.1]
["Sleep apnea syndrome","7/82 (8.5)","0/40 (0.0)","7/42 (16.7)",0.01]
["Alcohol overuse","1/89 (1.1)","0/48 (0.0)","1/41 (2.4)",0.5]
["Substance abuse","3/89 (3.4)","0/48 (0.0)","3/41 (7.3)",0.09]
["Cervical dissection","30/115 (26.1)","20/61 (32.8)","10/54 (18.5)",0.09]
["PFO","36/80 (45.0)","17/39 (43.6)","19/41 (46.3)",0.9]
["Pregnancy/Puerperium",null,"12/61 (19.6)"]
["Contraceptives or HRT",null,"15/61 (24.6)"]
["Non modifiable risk factors"]
["Family history of stroke","22/102 (21.6)","14/57 (24.6)","8/45 (17.8)",0.5]
["Family history of CHD","15/100 (15.0)","7/55 (12.7)","8/45 (17.8)",0.6]
[]
[]
[]
["Age 36-55y"]
["Variable/ Characteristic","Total n with condition/ valid n (%)","Female (n=206)","Male (n=364)","two-tailed p-value"]
["Modifiable risk factors"]
["Hypertension","227/570 (39.8)","77/206 (37.4)","150/364 (41.2)",0.4]
["Diabetes mellitus","57/566 (10.1)","23/204 (11.3)","34/362 (9.4)",0.5]
["Dyslipidemia","322/557 (57.8)","103/200 (51.5)","219/357 (61.3)",0.03]
["Smoking","232/555 (41.8)","70/200 (35.0)","162/355 (45.6)",0.02]
["Atrial fibrillation","21/569 (3.7)","7/206 (3.4)","14/363 (3.9)",1]
["Coronary heart disease","32/569 (5.6)","5/206 (2.4)","27/363 (7.4)",0.01]
["History of stroke","49/564 (8.7)","11/203 (5.4)","38/361 (10.5)",0.04]
["History of TIA","30/460 (6.5)","11/169 (6.5)","19/291 (6.5)",1]
["Underweight a","12/527 (2.3)","6/193 (3.1)","6/334 (1.8)",0.4]
["Overweight b","197/527 (37.4)","44/193 (22.8)","153/334 (45.8)","<0.001"]
["Obesity c","123/527 (23.3)","55/193 (28.5)","68/334 (20.4)",0.04]
["Sleep apnea syndrome","82/421 (19.5)","18/152 (11.8)","64/269 (23.8)",3.0000000000000001E-3]
["Alcohol overuse","51/425 (12.0)","12/147 (8.2)","39/278 (14.0)",0.09]
["Substance abuse","32/425 ((7.5)","4/146 (2.7)","28/279 (10.0)",6.0000000000000001E-3]
["Cervical dissection","86/561 (15.3)","24/203 (11.8)","62/358 (17.3)",0.09]
["PFO","161/408 (39.5)","57/153 (37.3)","104/255 (40.8)",0.5]
["Pregnancy/Puerperium",null,"1/207 (0.5)"]
["Contraceptives or HRT",null,"20/207 (9.7)"]
["Non modifiable risk factors"]
["Family history of stroke","96/436 (22.0)","34/156 (21.8)","62/280 (22.1)",1]
["Family history of CHD","101/421 (24.0)","42/151 (27.8)","59/270 (21.9)",0.2]

{"sheet":"Etiology","index":1,"n_rows":88,"n_cols":5,"rows_kept":88,"cut":false,"hidden":false,"merged":[]}
["Etiology according to TOAST classification"]
["Variables/Characteristics","Total n=687 (% of total n)","Female (n=269)","Male (n=418)","p-value"]
["Large-artery atherosclerosis","49 (7.1)","20 (7.4)","29 (6.9)"]
["Cardioembolism","70 (10.2)","23 (8.6)","47 (11.2)"]
["Small-vessel disease","22 (3.2)","5 (1.9)","17 (4.1)"]
["Other determined etiology","143 (20.8)","57 (21.2)","86 (20.6)"]
["Undetermined etiology despite complete evaluation","268 (39.0)","112 (41.6)","156 (37.3)"]
["Undetermined etiology with incomplete evaluation","89 (13.0)","32 (11.9)","57 (13.6)"]
["More than one possible etiology","46 (6.7)","20 (7.4)","26 (6.2)"]
[{"$nulls":4},0.5]
[]
[]
[]
["etiology","female (%)","male (%)"]
[1,7.4,6.9]
[2,8.6,11.2]
[3,1.9,4.0999999999999996]
[4,21.2,20.6]
[5,41.6,37.299999999999997]
[6,11.9,13.6]
[7,7.4,6.2]
["etiology","female (n)","male (n)"]
[1,20,29]
[2,23,47]
[3,5,17]
[4,57,86]
[5,112,156]
[6,32,57]
[7,20,26]
{"$rows_empty":7}
["16-35y"]
["Etiology according to TOAST classification"]
["Variables/Characteristics","n of total t=118 (%)","Female (n=64) (% of total)","Male (n=54) (% of total)","p-value"]
["Large-artery atherosclerosis","0 (0.0)","0 (0.0)","0 (0.0)"]
["Cardiac embolism","9 (7.6)","4 (6.3)","5 (9.3)"]
["Small-vessel disease","2 (1.7)","0 (0.0)","2 (3.7)"]
["Other determined etiology","38 (32.2)","25 (39.1)","13 (24.1)"]
["Undetermined etiology despite complete evaluation","46 (39.0)","22 (34.4)","24 (44.4)"]
["Undetermined etiology with incomplete evaluation","16 (13.6)","9 (14.1)","7 (13.0)"]
["More than one possible etiology","7 (5.9)","4 (6.3)","3 (5.6)"]
[{"$nulls":4},0.9]
[]
["36-55y"]
["Etiology according to TOAST classification"]
["Variables/Characteristics","n of total t=569 (%)","Female (n=205) (% of total)","Male (n=364) (% of total)","p-value"]
["Large-artery atherosclerosis","49 (8.6)","20 (9.8)","29 (8.0)"]
["Cardiac embolism","61 (10.7)","19 (9.3)","42 (11.5)"]
["Small-vessel disease","20 (3.5)","5 (2.4)","15 (4.1)"]
["Other determined etiology","105 (18.5)","32 (15.6)","73 (20.1)"]
["Undetermined etiology despite complete evaluation","222 (39.0)","90 (43.9)","132 (36.3)"]
["Undetermined etiology with incomplete evaluation","73 (12.8)","23 (11.2)","50 (13.7)"]
["More than one possible etiology","39 (6.9)","16 (7.8)","23 (6.3)"]
[{"$nulls":4},0.6]
[]
[]
[null,"Female (16-35y)","Male (16-35y)","Female (36-55y)","Male (36-55y)"]
[1,0,0,20,29]
[2,4,5,19,42]
[3,0,2,5,15]
[4,25,13,32,73]
[5,35,34,129,205]
[]
[null,"Female (16-35y)","Male (16-35y)","Female (36-55y)","Male (36-55y)"]
[1,0,0,10,8]
[2,6,9,9,12]
[3,0,4,2,4]
[4,39,24,16,20]
[5,55,63,63,56]
[]
[]
[null,"Female (16-35y)","Male (16-35y)","Female (36-55y)","Male (36-55y)"]
[1,0,0,10,8]
[2,6,9,9,12]
[3,0,4,2,4]
[4,39,24,16,20]
[5,55,63,63,56]
[]
[null,0,0,9.8000000000000007,8]
[null,6.3,9.3000000000000007,9.3000000000000007,11.5]
[null,0,3.7,2.4,4.0999999999999996]
[null,39.1,24.1,15.6,20.100000000000001]
[null,54.7,63,62.9,56.3]

{"sheet":"Localisation","index":2,"n_rows":19,"n_cols":18,"rows_kept":19,"cut":false,"hidden":false,"merged":[]}
["16-45y",{"$nulls":5},"46-55y",{"$nulls":6},"Location","Female (16-35y)","Male (16-35y)","Female (36-55y)","Male (36-55y)"]
["Location","Total (n=304)","Female (n=123)","Male (n=181)","two-tailed p-value",null,"Location","Total (n=385)","Female (n=147)","Male (n=238)","two-tailed p-value",null,null,"Posterior",0.22700000000000001,0.17599999999999999,0.11899999999999999,0.20399999999999999]
["Anterior","186 (61.2)","72 (58.5)","114 (63.0)",null,null,"Anterior","271 (70.4)","103 (70.1)","168 (70.6)",null,null,null,"Anterior",0.311,0.28599999999999998,0.24199999999999999,0.435]
["Posterior","118 (38.8)","51 (41.5)","67 (37.0)",null,null,"Posterior","114 (29.6)","44 (29.9)","70 (29.4)"]
[{"$nulls":4},0.5,{"$nulls":5},0.9]
[]
[]
["16-35y",{"$nulls":5},"36-55y"]
["Localization","Total (n=119)","Female (n=64)","Male (n=55)","two-tailed p-value",null,"Localization","Total (n=570)","Female (n=206)","Male (n=364)","two-tailed p-value"]
["Anterior","71 (59.7)","37 (57.8)","34 (61.8)",null,null,"Anterior","386 (67.7)","138 (67.0)","248 (68.1)"]
["Posterior","48 (40.3)","27 (42.2)","21 (38.2)",null,null,"Posterior","184 (32.3)","68 (33.0)","116 (31.9)"]
[{"$nulls":4},0.7,{"$nulls":5},0.8]
[]
[]
["In general"]
["Localization","Total (n=689)","Female (n=270)","Male (n=419)","two-tailed p-value",null,"Location","Female (16-35y)","Male (16-35y)","Female (36-55y)","Male (36-55y)",null,null,"Location","Female (n=270)","Male (n=419)"]
["Anterior","457 (66.3)","175 (64.8)","282 (67.3)",null,null,"Anterior",37,34,138,248,null,null,"Anterior",0.64800000000000002,0.67300000000000004]
["Posterior","232 (33.7)","95 (35.2)","137 (32.7)",null,null,"Posterior",27,21,68,116,null,null,"Posterior",0.35199999999999998,0.32700000000000001]
[{"$nulls":4},0.5]

{"sheet":"Therapy","index":3,"n_rows":12,"n_cols":6,"rows_kept":12,"cut":false,"hidden":false,"merged":[]}
[null,"valid n/total (t=689) (%)","Female (t=270)","Male (t=419)","Asymptomatic significance (two-tailed)"]
["Antiplatelet drugs","387 (56.2)","154 (57.0)","233 (55.6)",0.8]
["Anticoagulants","48 (7.0)","17 (6.3)","31/419 (7.4)",0.6]
["IVT with rTPA","126 (18.3)","40 (14.8)","86 (20.5)",7.0000000000000007E-2]
["IAT","138 (20.0)","54 (20.0)","84 (20.0)",1]
[]
[]
[null,null,"Female (n)","Male (n)","Female (%)","Male (%)"]
[null,"Antiplatelet drugs",154,233,57,55.6]
[null,"Anticoagulants",17,31,6.3,7.4]
[null,"IVT with rTPA",40,86,14.8,20.5]
[null,"IAT",54,84,20,20]

{"sheet":"Outcome","index":4,"n_rows":34,"n_cols":17,"rows_kept":34,"cut":false,"hidden":false,"merged":[]}
["Outcome after 3 months",{"$nulls":6},"total",null,"female","male",null,null,"Recurrence"]
["mRS","Total n=624  (n/% of total n)","Female (n=246)","Male (n=378)","two-tailed p-value",null,"favourable outcome",542,"86.9%",215,327,null,null,"total","Total (n=581, 77.8%)","Stroke or TIA","two-tailed p-value"]
[0,"185 (29.6)","78 (31.7)","107 (28.3)",null,null,"bad outcome",82,"13.1%",31,51,null,null,"Female",227,"10 (4.4%)"]
[1,"171 (27.4)","67 (27.2)","104 (27.5)",null,null,null,624,null,246,378,null,null,"Male",354,"10 (2.8%)"]
[2,"186 (29.8)","70 (28.5)","116 (30.7)",{"$nulls":12},0.39]
[3,"38 (6.1)","15 (6.1)","23 (6.1)"]
[4,"19 (3.0)","8 (3.3)","11 (2.9)"]
[5,"5 (0.8)","1 (0.4)","4 (1.1)"]
[6,"20 (3.2)","7 (2.8)","13 (3.4)"]
[{"$nulls":4},0.9]
[{"$nulls":8},"Outcome after 3 months"]
[{"$nulls":8},"Recurrence",{"$nulls":4},"Bad outcome (mRS > 2) "]
[null,"mRS","Female","Male","mRS","Female","Male",null,"16-35y","Total (n=104)","Stroke or TIA","two-tailed p-value",null,"16-35y","Total (n=112)","mRS > 2","two-tailed p-value"]
[null,0,32,28,0,78,107,null,"Female",54,"3 (5.6)",null,null,"Female",60,"3 (5.0)"]
[null,1,27,28,1,67,104,null,"Male",50,"1 (2.0)",null,null,"Male",52,"3 (5.8)"]
[null,2,29,31,2,70,116,{"$nulls":4},0.2,{"$nulls":4},1]
[null,3,6,6,3,15,23]
[null,4,3,3,4,8,11,null,"36-55y","Total (n=477)","Stroke or TIA","p-value",null,"36-55y","Total (n=513)","mRS > 2","p-value"]
[null,5,0,1,5,1,4,null,"Female",173,"7 (4.0)",null,null,"Female",186,"28 (15.1)"]
[null,6,3,3,6,7,13,null,"Male",304,"9 (3.0)",null,null,"Male",327,"49 (15.0)"]
[{"$nulls":11},0.6,{"$nulls":4},1]
[]
[{"$nulls":8},"Mortalität","Total",null,null,null,"Mortalität","Total"]
[{"$nulls":8},"36-55y","Total (n=108)",null,null,null,"36-55y","Total (n=515)"]
[{"$nulls":8},"Female",57,1,58,null,"Female",185,8,193]
[{"$nulls":8},"Male",51,0,51,null,"Male",330,16,346]
[{"$nulls":10},1,109,null,null,null,24,539]
[{"$nulls":10},"p-value","1.00",null,null,null,"p-value","1.00"]
[]
[{"$nulls":8},"Mortalität"]
[{"$nulls":8},"Total",575]
[{"$nulls":8},"Female",9]
[{"$nulls":8},"Male",16]
[{"$nulls":9},25,"p-value","0.836","exakter Test nach Fisher"]

{"sheet":"Age distribution","index":5,"n_rows":112,"n_cols":34,"rows_kept":112,"cut":false,"hidden":false,"merged":[]}
["Age (y)","Total (%)","Female (n=270)","Male (n=419)","p-value",{"$nulls":8},"16-45y",{"$nulls":14},"Age (y)","Total","Female","Male","p-value"]
["16-55","689 (100)","270 (39.2)","419 (60.8)",{"$nulls":24},"16-55",689,"270 (39.2)","419 (60.8)"]
["16-35","119 (17.3)","64 (53.8)","55 (46.2)","<0.001",{"$nulls":8},"Etiology according to TOAST classification",{"$nulls":5},"Female (%)","Male (%)",{"$nulls":7},"16-35",119,"64 (53.8)","55 (46.2)","<0.001"]
["36-55","570 (82.7)","206 (36.1)","364 (63.9)","<0.001",{"$nulls":8},"Variables/Characteristics","Total n=303 (n/% of total n)","Female (n=123) (% of total)","Male (n=180) (% of total)","p-value","16-35y",53.8,46.2,{"$nulls":7},"36-55",570,"206 (36.1)","364 (63.9)","<0.001"]
["16-45",304,"123 (40.5)","181 (59.5)",0.6,{"$nulls":8},"Large-artery atherosclerosis","4 (1.3)","0 (0.0)","4 (1.3)",null,"36-55y",36.1,63.9,{"$nulls":7},"16-45",304,"123 (40.5)","181 (59.5)",0.6]
["46-55",385,"147 (38.2)","238 (61.8)",0.6,{"$nulls":8},"Cardioembolism","26 (8.6)","8 (2.6)","18 (5.9)",{"$nulls":11},"46-55",385,"147 (38.2)","238 (61.8)",0.6]
[{"$nulls":13},"Small-vessel disease","6 (2.0)","1 (0.3)","5 (1.7)",null,null,"Female (n)","Male (n)"]
[{"$nulls":13},"Other determined etiology","90 (29.7)","42 (13.9)","48 (15.8)",null,"16-35y",64,55]
["16-45y",{"$nulls":5},"46-55y",{"$nulls":6},"Undetermined etiology despite complete evaluation","122 (40.3)","50 (16.5)","72 (23.8)",null,"36-55y",206,364]
["Risk factors stratified according to sex/gender in young ischemic stroke patients",{"$nulls":5},"Risk factors stratified according to sex/gender in young ischemic stroke patients",{"$nulls":6},"Undetermined etiology with incomplete evaluation","16 (","15 (5.0)","25 (8.3)"]
["Variable/Characteristic","Total n with condition/valid n (%)","Female (n=123)","Male (n=181)","two-tailed p-value",null,"Variable/Characteristic","Total n with condition/valid n (%)","Female (n=147)","Male (n=364)","two-tailed p-value",null,null,"More than one possible etiology","15 (5.0)","7 (2.3)","26 (6.2)"]
["Modifiable risk factors",{"$nulls":5},"Modifiable risk factors",{"$nulls":10},0.2]
["Hypertension","57/304 (18.8)","14/123 (11.4)","43/181 (23.8)",7.0000000000000001E-3,null,"Hypertension","179/385 (46.5)","66/147 (44.9)","113/238 (47.5)",0.7]
["Diabetes mellitus","12/298 (4.0)","4/118 (3.4)","8/180 (4.4)",0.8,null,"Diabetes mellitus","46/384 (12.0)","19/147 (12.9)","27/237 (11.4)",0.7,null,null,"46-55y"]
["Dyslipidemia","118/297 (39.7)","35/119 (29.4)","83/178 (46.6)",4.0000000000000001E-3,null,"Dyslipidemia","239/376 (63.6)","84/143 (58.7)","155/233 (66.5)",0.2,null,null,"Etiology according to TOAST classification"]
["Smoking","121/296 (40.9)","39/119 (32.8)","82/177 (46.3)",0.02,null,"Smoking","150/376 (39.9)","48/144 (33.3)","102/232 (44.0)",0.05,null,null,"Variables/Characteristics","Total n=384 (n/% of total n)","Female (n=146) (% of total)","Male (n=238) (% of total)","Asymptomatic significance (two-tailed)"]
["Atrial fibrillation","16/385 (4.2)","6/147 (4.1)","10/238 (4.2)",1,null,"Atrial fibrillation","5/303 (1.7)","1/123 (0.8)","4/180 (2.2)",0.7,null,null,"Large-artery atherosclerosis","45 (11.7)","20 (5.2)","25 (6.5)"]
["Coronary heart disease","5/303 (1.7)","0/123 (0.0)","5/180 (1.7)",0.08,null,"Coronary heart disease","27/385 (7.0)","5/147 (3.4)","22/238 (9.2)",0.04,null,null,"Cardioembolism","44 (11.5)","15 (3.9)","29 (7.6)"]
["History of stroke","23/297 (7.7)","5/118 (4.2)","18/179 (10.1)",0.08,null,"History of stroke","59/680 (8.7)","16/264 (6.1)","43/416 (10.3)",7.0000000000000007E-2,null,null,"Small-vessel disease","16 (4.2)","4 (1.0)","12 (3.1)"]
["History of TIA","21/241 (8.7)","7/98 (7.1)","14/143 (9.8)",0.6,null,"History of TIA","15/315 (4.8)","7/123 (5.7)","8/192 (4.2)",0.6,null,null,"Other determined etiology","53 (13.8)","15 (3.9)","38 (9.9)"]
["Underweight (BMI < 18.5 kg/m2)","9/282 (3.2)","5/116 (4.3)","4/166 (2.4)",0.5,null,"Underweight (BMI < 18.5 kg/m2)","8/358 (2.2)","4/138 (2.9)","4/220 (1.8)",0.5,null,null,"Undetermined etiology despite complete evaluation","146 (38.0)","62 (16.1)","84 (21.9)"]
["Overweight (BMI ≥ 25 kg/m2)","92/282 (32.6)","28/116 (24.1)","64/166 (38.6)",0.01,null,"Overweight (BMI ≥ 25 kg/m2)","134/358 (37.4)","29/138 (21.0)","105/220 (47.7)","<0.001",null,null,"Undetermined etiology with incomplete evaluation","49 (12.8)","17 (4.4)","32 8.3)"]
["Obesity (BMI ≥ 30 kg/m2)","53/282 (18.8)","18/116 (15.5)","35/166 (21.1)",0.3,null,"Obesity (BMI ≥ 30 kg/m2)","87/358 (24.3)","43/138 (31.2)","44/220 (20.0)",0.02,null,null,"More than one possible etiology","31 (8.1)","13 (3.4)","18 (4.7)",null,null,"16-35"]
["Sleep apnea syndrome","29/210 (13.8)","3/79 (3.8)","26/131 (19.8)",0.01,null,"Sleep apnea syndrome","60/293 (20.5)","15/113 (13.3)","45/180 (25.0)",0.02,{"$nulls":6},0.8,null,null,"Female","Male"]
["Alcohol overuse","13/231 (5.6)","3/91 (3.3)","10/140 (7.1)",0.3,null,"Alcohol overuse","39/283 (13.8)","9/104 (8.7)","30/179 (16.8)",7.0000000000000007E-2,{"$nulls":8},1,0,0]
["Substance abuse","16/232 (6.9)","1/91 (1.1)","15/141 (10.6)",6.0000000000000001E-3,null,"Substance abuse","19/282 (6.7)","3/103 (2.9)","16/179 (8.9)",0.08,{"$nulls":8},2,4,5]
["Cervical dissection","78/297 (26.3)","36/118 (30.5)","42/179 (23.5)",0.2,null,"Cervical dissection","38/379 (10.0)","8/146 (5.5)","30/233 (12.9)",0.02,{"$nulls":8},3,0,2]
["PFO","88/205 (42.9)","34/78 (43.6)","54/127 (42.5)",0.9,null,"PFO","109/283 (38.5)","40/114 (35.1)","69/169 (40.8)",0.4,{"$nulls":8},4,25,13]
["Pregnancy",null,"13/269 (1.9)",{"$nulls":16},5,35,34]
["Contraceptives or HRT",null,"35/270 (5.1)"]
["Non modifiable risk factors",{"$nulls":5},"Non modifiable risk factors",{"$nulls":12},"36-55y"]
["Family history of stroke","55/250 (22.0)","25/106 (23.6)","30/144 (20.8)",0.6,null,"Family history of stroke","63/288 (21.9)","23/107 (21.5)","40/181 (22.1)",1,null,null,"16-35y",{"$nulls":6},"Female","Male"]
["Family history of CHD","56/245 (22.9)","19/103 (18.4)","37/142 (26.1)",0.2,null,"Family history of CHD","60/276 (21.7)","30/103 (29.1)","30/173 (17.3)",0.02,null,null,"Etiology according to TOAST classification",{"$nulls":5},1,20,4]
[{"$nulls":13},"Variables/Characteristics","Total n=119 (n/% of total n)","Female (n=64) (% of total)","Male (n=55) (% of total)","p-value",null,2,19,18]
[{"$nulls":13},"Large-artery atherosclerosis","0 (0.0)","0 (0.0)","0 (0.0)",null,null,3,5,5]
["16-35y",{"$nulls":5},"36-55y",{"$nulls":6},"Cardioembolism","9 (7.6)","4 (3.4)","5 (4.2)",null,null,4,32,48]
["Risk factors stratified according to sex/gender in young ischemic stroke patients",{"$nulls":5},"Risk factors stratified according to sex/gender in young ischemic stroke patients",{"$nulls":6},"Small-vessel disease","2 (1.7)","0 (0.0)","2 (1.7)",null,null,5,129,123]
["Variable/Characteristic","Total n with condition/valid n (%)","Female (n=206)","Male (n=181)","two-tailed p-value",null,"Variable/Characteristic","Total n with condition/valid n (%)","Female (n=206)","Male (n=181)","two-tailed p-value",null,null,"Other determined etiology","38 (32.2)","25 (21.2)","13 (11.0)"]
["Modifiable risk factors",{"$nulls":5},"Modifiable risk factors",{"$nulls":6},"Undetermined etiology despite complete evaluation","46 (39.0)","22 (18.6)","24 (20.3)"]
["Hypertension","9/119 (7.6)","3/64 (4.7)","6/55 (10.9)",0.3,null,"Hypertension","227/570 (39.8)","77/206 (37.4)","150/364 (41.2)",0.4,null,null,"Undetermined etiology with incomplete evaluation","16 (13.6)","9 (7.6)","7 (5.9)"]
["Diabetes mellitus","1/116 (0.9)","0/61 (0.0)","1/55 (1.8)",0.5,null,"Diabetes mellitus","57/566 (10.1)","23/204 (11.3)","34/362 (9.4)",0.5,null,null,"More than one possible etiology","7 (5.9)","4 (3.4)","3 (2.5)"]
["Dyslipidemia","35/116 (30.2)","16/62 (25.8)","19/54 (35.2)",0.3,null,"Dyslipidemia","322/557 (57.8)","103/200 (51.5)","219/357 (61.3)",0.03,{"$nulls":6},0.9,null,"Risk factors stratified according to sex/gender in young ischemic stroke patients"]
["Smoking","39/17 (33.3)","17/63 (27.0)","22/54 (40.7)",0.1,null,"Smoking","232/555 (41.8)","70/200 (35.0)","162/355 (45.6)",0.02,{"$nulls":8},"General population",{"$nulls":4},"Age 16-35y",null,null,null,"Age 36-55y"]
["Atrial fibrillation","0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1,null,"Atrial fibrillation","21/569 (3.7)","7/206 (3.4)","14/363 (3.9)",1,null,null,"36-55y",{"$nulls":5},"Variable/ Characteristic","Total n with condition/valid n (%)","Female n=270 (%)","Male n=419 (%)","two-tailed p-value","Total n with con-dition/valid n (%)","Female n=64 (%)","Male n=55 (%)","two-tailed p-value","Total n with con-dition/valid n (%)","Female n=206 (%)","Male n=364 (%)","two-tailed p-value"]
["Coronary heart disease","0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1,null,"Coronary heart disease","32/569 (5.6)","5/206 (2.4)","27/363 (7.4)",0.01,null,null,"Etiology according to TOAST classification",{"$nulls":5},"Modifiable risk factors",{"$nulls":13},"a BMI < 18.5 kg/m2"]
["History of stroke","10/116 (8.6)","5/61 (8.2)","5/55 (9.1)",1,null,"History of stroke","49/564 (8.7)","11/203 (5.4)","38/361 (10.5)",0.04,null,null,"Variables/Characteristics","Total n=569 (n/% of total n)","Female (n=205) (% of total)","Male (n=364) (% of total)","p-value",null,"Hypertension","236/689 (34.3)","80/270 (29.6)","156/419 (37.2)",4.8000000000000001E-2,"9/119 (7.6)","3/64 (4.7)","6/55 (10.9)",0.3,"227/570 (39.8)","77/206 (37.4)","150/364 (41.2)",0.4,null,"b BMI ≥ 25 kg/m2"]
["History of TIA","6/96 (6.3)","3/52 (3.1)","3/44 (3.1)",1,null,"History of TIA","30/460 (6.5)","11/169 (6.5)","19/291 (6.5)",1,null,null,"Large-artery atherosclerosis","49 (8.6)","20 (3.5)","4 (1.3)",null,null,"Diabetes mellitus","58/682 (8.5)","23/265 (8.7)","35/417 (8.4)",0.9,"1/116 (0.9)","0/61 (0.0)","1/55 (1.8)",0.5,"57/566 (10.1)","23/204 (11.3)","34/362 (9.4)",0.5,null,"c BMI ≥ 30 kg/m2"]
["Underweight (BMI < 18.5 kg/m2)","5/113 (4.4)","3/61 (4.9)","2/52 (3.8)",1,null,"Underweight (BMI < 18.5 kg/m2)","12/527 (2.3)","6/193 (3.1)","6/334 (1.8)",0.4,null,null,"Cardioembolism","61 (10.7)","19 (3.3)","18 (5.9)",null,null,"Dyslipidemia","357/673 (53.0)","119/262 (45.4)","238/411 (57.9)",2E-3,"35/116 (30.2)","16/62 (25.8)","19/54 (35.2)",0.3,"322/557 (57.8)","103/200 (51.5)","219/357 (61.3)",0.03]
["Overweight (BMI ≥ 25 kg/m2)","29/113 (25.7)","13/61 (21.3)","16/52 (30.8)",0.3,null,"Overweight (BMI ≥ 25 kg/m2)","197/527 (37.4)","44/193 (22.8)","153/334 (45.8)","<0.001",null,null,"Small-vessel disease","20 (3.5)","5 (0.9)","5 (1.7)",null,null,"Smoking","271/672 (40.3)","87/263 (33.1)","184/409 (45.0)",2E-3,"39/17 (33.3)","17/63 (27.0)","22/54 (40.7)",0.1,"232/555 (41.8)","70/200 (35.0)","162/355 (45.6)",0.02]
["Obesity (BMI ≥ 30 kg/m2)","17/113 (15.0)","6/61 (9.8)","11/52 (21.2)",0.1,null,"Obesity (BMI ≥ 30 kg/m2)","123/527 (23.3)","55/193 (28.5)","68/334 (20.4)",0.04,null,null,"Other determined etiology","105 (18.5)","32 (5.6)","48 (15.8)",null,null,"Atrial fibrillation","21/688 (3.1)","7/270 (2.6)","14/418 (3.3)",0.7,"0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1,"21/569 (3.7)","7/206 (3.4)","14/363 (3.9)",1]
["Sleep apnea syndrome","7/82 (8.5)","0/40 (0.0)","7/42 (16.7)",0.01,null,"Sleep apnea syndrome","82/421 (19.5)","18/152 (11.8)","64/269 (23.8)",3.0000000000000001E-3,null,null,"Undetermined etiology despite complete evaluation","222 (39.0)","90 (15.8)","72 (23.8)",null,null,"Coronary heart disease","32/688 (4.7)","5/270 (1.9)","27/418 (6.5)",5.0000000000000001E-3,"0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1,"32/569 (5.6)","5/206 (2.4)","27/363 (7.4)",0.01]
["Alcohol overuse","1/89 (1.1)","0/48 (0.0)","1/41 (2.4)",0.5,null,"Alcohol overuse","51/425 (12.0)","12/147 (8.2)","39/278 (14.0)",0.09,null,null,"Undetermined etiology with incomplete evaluation","73 (12.8)","23 (4.0)","25 (8.3)",null,null,"History of stroke","59/680 (8.7)","16/264 (6.1)","43/416 (10.3)",7.0000000000000007E-2,"10/116 (8.6)","5/61 (8.2)","5/55 (9.1)",1,"49/564 (8.7)","11/203 (5.4)","38/361 (10.5)",0.04]
["Substance abuse","3/89 (3.4)","0/48 (0.0)","3/41 (7.3)",0.09,null,"Substance abuse","32/425 ((7.5)","4/146 (2.7)","28/279 (10.0)",6.0000000000000001E-3,null,null,"More than one possible etiology","39 (6.9)","16 (2.8)","26 (6.2)",null,null,"History of TIA","34/546 (6.2)","14/223 (6.3)","20/323 (6.2)",1,"6/96 (6.3)","3/52 (3.1)","3/44 (3.1)",1,"30/460 (6.5)","11/169 (6.5)","19/291 (6.5)",1]
["Cervical dissection","30/115 (26.1)","20/61 (32.8)","10/54 (18.5)",0.09,null,"Cervical dissection","86/561 (15.3)","24/203 (11.8)","62/358 (17.3)",0.09,{"$nulls":6},0.6,null,"Underweight a","17/689 (1.2)","9/270 (3.3)","8/419 (1.9)",0.3,"5/113 (4.4)","3/61 (4.9)","2/52 (3.8)",1,"12/527 (2.3)","6/193 (3.1)","6/334 (1.8)",0.4]
["PFO","36/80 (45.0)","17/39 (43.6)","19/41 (46.3)",0.9,null,"PFO","161/408 (39.5)","57/153 (37.3)","104/255 (40.8)",0.5,{"$nulls":8},"Overweight b","224/680 (32.9)","57/266 (21.4)","167/414 (40.3)","<0.001","29/113 (25.7)","13/61 (21.3)","16/52 (30.8)",0.3,"197/527 (37.4)","44/193 (22.8)","153/334 (45.8)","<0.001"]
["Non modifiable risk factors",{"$nulls":5},"Non modifiable risk factors",{"$nulls":12},"Obesity c","140/646 (21.7)","61/257 (23.7)","79/389 (20.3)",0.4,"17/113 (15.0)","6/61 (9.8)","11/52 (21.2)",0.1,"123/527 (23.3)","55/193 (28.5)","68/334 (20.4)",0.04]
["Family history of stroke","22/102 (21.6)","14/57 (24.6)","8/45 (17.8)",0.5,null,"Family history of stroke","96/436 (22.0)","34/156 (21.8)","62/280 (22.1)",1,{"$nulls":8},"Sleep apnea syndrome (SAS)","89/444 (20.0)","18/176 (10.2)","71/268 (26.5)","<0.001","7/82 (8.5)","0/40 (0.0)","7/42 (16.7)",0.01,"82/421 (19.5)","18/152 (11.8)","64/269 (23.8)",3.0000000000000001E-3]
["Family history of CHD","15/100 (15.0)","7/55 (12.7)","8/45 (17.8)",0.6,null,"Family history of CHD","101/421 (24.0)","42/151 (27.8)","59/270 (21.9)",0.2,{"$nulls":8},"Alcohol overuse","52/514 (10.1)","12/195 (6.2)","40/319 (12.5)",0.02,"1/89 (1.1)","0/48 (0.0)","1/41 (2.4)",0.5,"51/425 (12.0)","12/147 (8.2)","39/278 (14.0)",0.09]
[{"$nulls":19},"Substance abuse","35/514 (6.8)","4/194 (2.1)","31/320 (9.7)",1E-3,"3/89 (3.4)","0/48 (0.0)","3/41 (7.3)",0.09,"32/425 ((7.5)","4/146 (2.7)","28/279 (10.0)",6.0000000000000001E-3]
[{"$nulls":19},"Cervical dissection","117/687 (17.0)","45/270 (16.7)","72/417 (17.3)",0.9,"30/115 (26.1)","20/61 (32.8)","10/54 (18.5)",0.09,"86/561 (15.3)","24/203 (11.8)","62/358 (17.3)",0.09]
["Risk factors stratified according to sex/gender in young ischemic stroke patients",{"$nulls":18},"PFO","197/488 (40.4)","74/192 (38.5)","123/296 (41.6)",0.6,"36/80 (45.0)","17/39 (43.6)","19/41 (46.3)",0.9,"161/408 (39.5)","57/153 (37.3)","104/255 (40.8)",0.5]
["General population",{"$nulls":4},"Age 16-35y",null,null,null,"Age 36-55y",{"$nulls":9},"Pregnancy",null,"13/270 (4.8)"]
["Variable/ Characteristic","Total n with condition/valid n (%)","Female (n=270)","Male (n=419)","two-tailed p-value","Total n with con-dition/valid n (%)","Female n=64 (%)","Male n=55 (%)","two-tailed p-value","Total n with con-dition/valid n (%)","Female (n=206)","Male (n=181)","two-tailed p-value",{"$nulls":6},"Contraceptives or HRT",null,"35/270 (5.1)"]
["Modifiable risk factors",{"$nulls":18},"Non modifiable risk factors"]
["Hypertension","236/689 (34.3)","80/270 (29.6)","156/419 (37.2)",4.8000000000000001E-2,"9/119 (7.6)","3/64 (4.7)","6/55 (10.9)",0.3,"227/570 (39.8)","77/206 (37.4)","150/364 (41.2)",0.4,{"$nulls":6},"Family history of stroke","118/538 (21.9)","48//213 (22.5)","70/325 (21.5)",0.8,"22/102 (21.6)","14/57 (24.6)","8/45 (17.8)",0.5,"96/436 (22.0)","34/156 (21.8)","62/280 (22.1)",1]
["Diabetes mellitus","58/682 (8.5)","23/265 (8.7)","35/417 (8.4)",0.9,"1/116 (0.9)","0/61 (0.0)","1/55 (1.8)",0.5,"57/566 (10.1)","23/204 (11.3)","34/362 (9.4)",0.5,{"$nulls":6},"Family history of CHD","116/521 (22.3)","49/206 (23.8)","67/315 (21.3)",0.5,"15/100 (15.0)","7/55 (12.7)","8/45 (17.8)",0.6,"101/421 (24.0)","42/151 (27.8)","59/270 (21.9)",0.2]
["Dyslipidemia","357/673 (53.0)","119/262 (45.4)","238/411 (57.9)",2E-3,"35/116 (30.2)","16/62 (25.8)","19/54 (35.2)",0.3,"322/557 (57.8)","103/200 (51.5)","219/357 (61.3)",0.03]
["Smoking","271/672 (40.3))","87/263 (33.1)","184/409 (45.0)",2E-3,"39/17 (33.3)","17/63 (27.0)","22/54 (40.7)",0.1,"232/555 (41.8)","70/200 (35.0)","162/355 (45.6)",0.02,{"$nulls":6},"Age 16-35y"]
["Atrial fibrillation","21/688 (3.1)","7/270 (2.6)","14/418 (3.3)",0.7,"0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1,"21/569 (3.7)","7/206 (3.4)","14/363 (3.9)",1,{"$nulls":6},"Variable/ Characteristic","Total n with condition/valid n (%)","Female n=64 (%)","Male n=55 (%)","two-tailed p-value"]
["Coronary heart disease","32/688 (4.7)","5/270 (1.9)","27/418 (6.5)",5.0000000000000001E-3,"0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1,"32/569 (5.6)","5/206 (2.4)","27/363 (7.4)",0.01,{"$nulls":6},"Modifiable risk factors"]
["History of stroke","59/680 (8.7)","16/264 (6.1)","43/416 (10.3)",7.0000000000000007E-2,"10/116 (8.6)","5/61 (8.2)","5/55 (9.1)",1,"49/564 (8.7)","11/203 (5.4)","38/361 (10.5)",0.04,{"$nulls":6},"Hypertension","9/119 (7.6)","3/64 (4.7)","6/55 (10.9)",0.3]
["History of TIA","34/546 (6.2)","14/223 (6.3)","20/323 (6.2)",1,"6/96 (6.3)","3/52 (3.1)","3/44 (3.1)",1,"30/460 (6.5)","11/169 (6.5)","19/291 (6.5)",1,{"$nulls":6},"Diabetes mellitus","1/116 (0.9)","0/61 (0.0)","1/55 (1.8)",0.5]
["Underweight a","17/689 (1.2)","9/270 (3.3)","8/419 (1.9)",0.3,"5/113 (4.4)","3/61 (4.9)","2/52 (3.8)",1,"12/527 (2.3)","6/193 (3.1)","6/334 (1.8)",0.4,{"$nulls":6},"Dyslipidemia","35/116 (30.2)","16/62 (25.8)","19/54 (35.2)",0.3]
["Overweight b","224/680 (32.9)","57/266 (21.4)","167/414 (40.3)","<0.001","29/113 (25.7)","13/61 (21.3)","16/52 (30.8)",0.3,"197/527 (37.4)","44/193 (22.8)","153/334 (45.8)","<0.001",{"$nulls":6},"Smoking","39/17 (33.3)","17/63 (27.0)","22/54 (40.7)",0.1]
["Obesity c","140/646 (21.7)","61/257 (23.7)","79/389 (20.3)",0.4,"17/113 (15.0)","6/61 (9.8)","11/52 (21.2)",0.1,"123/527 (23.3)","55/193 (28.5)","68/334 (20.4)",0.04,{"$nulls":6},"Atrial fibrillation","0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1]
["Sleep apnea syndrome","89/444 (20.0)","18/176 (10.2)","71/268 (26.5)","<0.001","7/82 (8.5)","0/40 (0.0)","7/42 (16.7)",0.01,"82/421 (19.5)","18/152 (11.8)","64/269 (23.8)",3.0000000000000001E-3,{"$nulls":6},"Coronary heart disease","0/119 (0.0)","0/64 (0.0)","0/55 (0.0)",1]
["Alcohol overuse","52/514 (10.1)","12/195 (6.2)","40/319 (12.5)",0.02,"1/89 (1.1)","0/48 (0.0)","1/41 (2.4)",0.5,"51/425 (12.0)","12/147 (8.2)","39/278 (14.0)",0.09,{"$nulls":6},"History of stroke","10/116 (8.6)","5/61 (8.2)","5/55 (9.1)",1]
["Substance abuse","35/514 (6.8)","4/194 (2.1)","31/320 (9.7)",1E-3,"3/89 (3.4)","0/48 (0.0)","3/41 (7.3)",0.09,"32/425 ((7.5)","4/146 (2.7)","28/279 (10.0)",6.0000000000000001E-3,{"$nulls":6},"History of TIA","6/96 (6.3)","3/52 (3.1)","3/44 (3.1)",1]
["Cervical dissection","117/687 (17.0)","45/270 (16.7)","72/417 (17.3)",0.9,"30/115 (26.1)","20/61 (32.8)","10/54 (18.5)",0.09,"86/561 (15.3)","24/203 (11.8)","62/358 (17.3)",0.09,{"$nulls":6},"Underweight a","5/113 (4.4)","3/61 (4.9)","2/52 (3.8)",1]
["PFO",{"$nulls":4},"36/80 (45.0)","17/39 (43.6)","19/41 (46.3)",0.9,"161/408 (39.5)","57/153 (37.3)","104/255 (40.8)",0.5,{"$nulls":6},"Overweight b","29/113 (25.7)","13/61 (21.3)","16/52 (30.8)",0.3]
["Non modifiable risk factors",{"$nulls":18},"Obesity c","17/113 (15.0)","6/61 (9.8)","11/52 (21.2)",0.1]
["Family history of stroke","118/538 (21.9)","48//213 (22.5)","70/325 (21.5)",0.8,"22/102 (21.6)","14/57 (24.6)","8/45 (17.8)",0.5,"96/436 (22.0)","34/156 (21.8)","62/280 (22.1)",1,{"$nulls":6},"Sleep apnea syndrome","7/82 (8.5)","0/40 (0.0)","7/42 (16.7)",0.01]
["Family history of CHD","116/521 (22.3)","49/206 (23.8)","67/315 (21.3)",0.5,"15/100 (15.0)","7/55 (12.7)","8/45 (17.8)",0.6,"101/421 (24.0)","42/151 (27.8)","59/270 (21.9)",0.2,{"$nulls":6},"Alcohol overuse","1/89 (1.1)","0/48 (0.0)","1/41 (2.4)",0.5]
[{"$nulls":19},"Substance abuse","3/89 (3.4)","0/48 (0.0)","3/41 (7.3)",0.09]
["a BMI < 18.5 kg/m2",{"$nulls":18},"Cervical dissection","30/115 (26.1)","20/61 (32.8)","10/54 (18.5)",0.09]
["b BMI ≥ 25 kg/m2",{"$nulls":18},"PFO","36/80 (45.0)","17/39 (43.6)","19/41 (46.3)",0.9]
["c BMI ≥ 30 kg/m2",{"$nulls":18},"Non modifiable risk factors"]
[{"$nulls":19},"Family history of stroke","22/102 (21.6)","14/57 (24.6)","8/45 (17.8)",0.5]
["16-35y",null,null,"36-55y",null,null,"Gesamt",{"$nulls":12},"Family history of CHD","15/100 (15.0)","7/55 (12.7)","8/45 (17.8)",0.6]
[null,"Female","Male",null,"Female","Male",null,"Female","Male"]
["Hypertension",3,6,"Hypertension",77,150,"Hypertension",80,156,{"$nulls":10},"Age 36-55y"]
["Diabetes",0,1,"Diabetes",23,34,"Diabetes",23,35,{"$nulls":10},"Variable/ Characteristic","Total n with condition/valid n (%)","Female n=206 (%)","Male n=364 (%)","two-tailed p-value"]
["Dyslipidemia",16,19,"Dyslipidemia",103,219,"Dyslipidemia",119,238,{"$nulls":10},"Modifiable risk factors"]
["Smoking",17,22,"Smoking",70,162,"Smoking",87,184,{"$nulls":10},"Hypertension","227/570 (39.8)","77/206 (37.4)","150/364 (41.2)",0.4]
["Atrial fibrillation",0,0,"Atrial fibrillation",7,14,"Atrial fibrillation",7,14,{"$nulls":10},"Diabetes mellitus","57/566 (10.1)","23/204 (11.3)","34/362 (9.4)",0.5]
["CHD",0,0,"CHD",5,27,"CHD",5,27,{"$nulls":10},"Dyslipidemia","322/557 (57.8)","103/200 (51.5)","219/357 (61.3)",0.03]
["History of stroke",5,5,"History of stroke",11,38,"History of stroke",16,43,{"$nulls":10},"Smoking","232/555 (41.8)","70/200 (35.0)","162/355 (45.6)",0.02]
["History of TIA",3,3,"History of TIA",11,19,"History of TIA",14,22,{"$nulls":10},"Atrial fibrillation","21/569 (3.7)","7/206 (3.4)","14/363 (3.9)",1]
["Underweight",3,2,"Underweight",6,6,"Underweight",9,8,{"$nulls":10},"Coronary heart disease","32/569 (5.6)","5/206 (2.4)","27/363 (7.4)",0.01]
["Overweight",13,16,"Overweight",44,153,"Overweight",57,169,{"$nulls":10},"History of stroke","49/564 (8.7)","11/203 (5.4)","38/361 (10.5)",0.04]
["Obesity",6,11,"Obesity",55,68,"Obesity",61,79,{"$nulls":10},"History of TIA","30/460 (6.5)","11/169 (6.5)","19/291 (6.5)",1]
["SAS",0,7,"SAS",18,64,"SAS",18,71,{"$nulls":10},"Underweight a","12/527 (2.3)","6/193 (3.1)","6/334 (1.8)",0.4]
["Alcohol overuse",0,1,"Alcohol overuse",12,39,"Alcohol overuse",12,40,{"$nulls":10},"Overweight b","197/527 (37.4)","44/193 (22.8)","153/334 (45.8)","<0.001"]
["Substance abuse",0,3,"Substance abuse",4,28,"Substance abuse",4,31,{"$nulls":10},"Obesity c","123/527 (23.3)","55/193 (28.5)","68/334 (20.4)",0.04]
["Cervical dissection",20,10,"Cervical dissection",24,62,"Cervical dissection",44,72,{"$nulls":10},"Sleep apnea syndrome","82/421 (19.5)","18/152 (11.8)","64/269 (23.8)",3.0000000000000001E-3]
["PFO",17,19,"PFO",57,104,"PFO",74,123,{"$nulls":10},"Alcohol overuse","51/425 (12.0)","12/147 (8.2)","39/278 (14.0)",0.09]
[null,"Female","Male",null,"Female","Male",{"$nulls":13},"Substance abuse","32/425 ((7.5)","4/146 (2.7)","28/279 (10.0)",6.0000000000000001E-3]
["Family history of stroke",14,8,"Family history of stroke",34,62,"Family history of stroke",48,70,{"$nulls":10},"Cervical dissection","86/561 (15.3)","24/203 (11.8)","62/358 (17.3)",0.09]
["Family history of CHD",7,8,"Family history of CHD",42,59,"Family history of CHD",49,67,{"$nulls":10},"PFO","161/408 (39.5)","57/153 (37.3)","104/255 (40.8)",0.5]
[{"$nulls":19},"Non modifiable risk factors"]
[{"$nulls":19},"Family history of stroke","96/436 (22.0)","34/156 (21.8)","62/280 (22.1)",1]
[{"$nulls":19},"Family history of CHD","101/421 (24.0)","42/151 (27.8)","59/270 (21.9)",0.2]

{"sheet":"RoPE-Score","index":6,"n_rows":11,"n_cols":4,"rows_kept":11,"cut":false,"hidden":false,"merged":[]}
[null,"Female n=61 (%)","Male n=107 (%)","p-value"]
["PFO n=197/488 (40.4%)","74 (38.5)","123 (41.6)",0.6]
["RoPE-Score > 7 n=168/197 (85.3%)","23 (37.7)","18 (16.8)",5.0000000000000001E-3]
[]
["16-35y"]
[null,"Female n=14 (%)","Male n=16  (%)","p-value"]
["RoPE-Score > 7 n=168","14 (100)","8 (50)",3.0000000000000001E-3]
[]
["36-55y"]
[null,"Female n=47 (%)","Male n=91 (%)","p-value"]
["RoPE-Score > 7 n=168","9 (19.1)","10 (11.0)",0.2]

{"sheet":"BFS","index":7,"n_rows":8,"n_cols":12,"rows_kept":8,"cut":false,"hidden":false,"merged":[]}
[null,"Study population (age 36-55y)",null,"General Swiss population (age 35-54y)",{"$nulls":4},"Study population (age 36-55y)",null,"General Swiss population (age 35-54y)"]
["Traditional risk factors","Female n=270 (%)","Male n=419 (%)","Female (%)","Male (%)",null,null,"Traditional risk factors","Female n=270 (%)","Male n=419 (%)","Female (%)","Male (%)"]
["Hypertension",37.4,41.2,"12.7 - 20.0","18.7 - 27.1",null,null,"Hypertension",37,41,"12.7 - 20.0","18.7 - 27.1"]
["Dyslipidemia",57.8,61.3,"8.7 - 13.7","11.6 - 22.0",null,null,"Dyslipidemia",58,61,"8.7 - 13.7","11.6 - 22.0"]
["Smoking",35,45.6,"24.6 - 26.6","30.6 - 36.7",null,null,"Smoking",35,46,"24.6 - 26.6","30.6 - 36.7"]
["Diabetes",11.3,9.4,"3.0 - 3.1","1.0 - 3.6",null,null,"Diabetes",11,9,"3.0 - 3.1","1.0 - 3.6"]
["Overweight",22.8,45.8,"19.3 - 24.0","39.9 - 42.9",null,null,"Overweight",23,46,"19.3 - 24.0","39.9 - 42.9"]
["Obesity",28.5,20.399999999999999,"9.1 - 12.1","11.0 - 14.4",null,null,"Obesity",29,20,"9.1 - 12.1","11.0 - 14.4"]

{"sheet":"times","index":8,"n_rows":28,"n_cols":11,"rows_kept":28,"cut":false,"hidden":false,"merged":[]}
["16-35y",{"$nulls":4},"Gesamtpopulation","Total","Time to imaging from symptom onset known"]
[null,"Total (n=61)","Time symptom onset to diagnosis (onset known only)","two-tailed p-value",null,null,"n=689","yes (n=366, 53.4%)","no (n=230, 33.4%)","wake up (n=91, 13.2%)"]
["Female",33,32.15,null,null,"Female",null,142,null,34]
["Male",28,29.64,null,null,"Male",null,224,null,57]
[null,null,null,0.6,null,null,null,366,null,91]
[null,"Total (n=70)","Time symptom onset to diagnosis (onset known+wake up)","two-tailed p-value",null,"Mann-Whitney-U-Test",null,14709,null,23590]
["Female",36,35.25,null,null,"Wilcoxon-W",null,39909,null,63211]
["Male",34,35.76,null,null,"asympt. Signifikanz",null,"0.226",null,"0.408"]
[null,null,null,0.9]
[]
["36-55y",{"$nulls":4},"16-35y"]
[null,"Total (n=305)","Time symptom onset to diagnosis (onset known only)","two-tailed p-value",null,null,"n=","yes (n=61)","no (n=)","wake up (n=9)"]
["Female",109,159.72,null,null,"Female",null,33,null,3,36]
["Male",196,149.26,null,null,"Male",null,28,null,6,34]
[null,null,null,0.3,null,null,null,61,null,9,70]
[null,"Total (n=387)","Time symptom onset to diagnosis (onset known+wake up)","two-tailed p-value",null,"Mann-Whitney-U-Test",null,424,null,603]
["Female",140,201.07,null,null,"Wilcoxon-W",null,830,null,830]
["Male",247,189.99,null,null,"asympt. Signifikanz",null,"0.582",null,"0.916"]
[null,null,null,0.3]
[]
[{"$nulls":5},"36-55y ",null,"time from symptom onset known to imaging"]
[{"$nulls":6},"n=305","yes","no (n=, %)","wake up"]
[{"$nulls":5},"Female",null,109,null,31,140]
[{"$nulls":5},"Male",null,196,null,51,247]
[{"$nulls":7},305,null,82]
[{"$nulls":5},"Mann-Whitney-U-Test",null,9949,null,16300]
[{"$nulls":5},"Wilcoxon-W",null,29255,null,46928]
[{"$nulls":5},"asympt. Signifikanz",null,"0.321",null,"0.349"]